(Q42521815)

1 November 2017

title

Polymers of alpha(1)-antitrypsin are chemotactic for human neutrophils: a new paradigm for the pathogenesis of emphysema (English)

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1 November 2017

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Edwin R Chilvers

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Jasvir S Parmar

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1 November 2017

Ravi Mahadeva

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1 November 2017

Benjamin J Reed

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1 November 2017

Neda Farahi

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1 November 2017

Karen A Cadwallader

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1 November 2017

Mary T Keogan

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1 November 2017

Diana Bilton

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1 November 2017

David A Lomas

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1 November 2017

publication date

1 June 2002

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American Journal of Respiratory Cell and Molecular Biology

1 November 2017

published in

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1 November 2017

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1 November 2017

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1 November 2017

page(s)

723-730

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Decline in FEV1 related to smoking status in individuals with severe alpha1-antitrypsin deficiency (PiZZ).

1 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1165%2FAJRCMB.26.6.4739

Molecular abnormality of human alpha1-antitrypsin variant (Pi-ZZ) associated with plasma activity deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FAJRCMB.26.6.4739

Human alpha 1-proteinase inhibitor. Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for function

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FAJRCMB.26.6.4739

Inhibitory conformation of the reactive loop of alpha 1-antitrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FAJRCMB.26.6.4739

The mechanism of Z alpha 1-antitrypsin accumulation in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FAJRCMB.26.6.4739

Mutations which impede loop/sheet polymerization enhance the secretion of human alpha 1-antitrypsin deficiency variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FAJRCMB.26.6.4739

The inhibitory complex of human alpha 1-proteinase inhibitor and human leukocyte elastase is a neutrophil chemoattractant

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FAJRCMB.26.6.4739

Lung polymers in Z alpha1-antitrypsin deficiency-related emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FAJRCMB.26.6.4739

Subcellular location and properties of bactericidal factors from human neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FAJRCMB.26.6.4739

The serpin-enzyme complex (SEC) receptor mediates the neutrophil chemotactic effect of alpha-1 antitrypsin-elastase complexes and amyloid-beta peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FAJRCMB.26.6.4739

Chemotactic response of neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FAJRCMB.26.6.4739

Structure and variation of human alpha 1-antitrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FAJRCMB.26.6.4739

Heteropolymerization of S, I, and Z alpha1-antitrypsin and liver cirrhosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FAJRCMB.26.6.4739

Neutrophil accumulation in the lung in alpha 1-antitrypsin deficiency. Spontaneous release of leukotriene B4 by alveolar macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FAJRCMB.26.6.4739

Biosynthesis of alpha1-proteinase inhibitor by human lung-derived epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FAJRCMB.26.6.4739

Expression of the alpha-1-antitrypsin gene in mononuclear phagocytes of normal and alpha-1-antitrypsin-deficient individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FAJRCMB.26.6.4739

Lung lavage fluid from patients with alpha 1-proteinase inhibitor deficiency or chronic obstructive bronchitis: anti-elastase function and cell profile

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FAJRCMB.26.6.4739

Smoking, lung function, and alpha 1-antitrypsin deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FAJRCMB.26.6.4739

Alpha 1-antitrypsin deficiency: evaluation of bronchiectasis with CT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FAJRCMB.26.6.4739

A Kinetic Mechanism for the Polymerization of α1-Antitrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FAJRCMB.26.6.4739

Pathogenic α1-Antitrypsin Polymers Are Formed by Reactive Loop-β-Sheet A Linkage

21 January 2018

1 reference

https://api.crossref.org/works/10.1165%2FAJRCMB.26.6.4739

21 January 2018

Identifiers

DOI

10.1165/AJRCMB.26.6.4739

1 reference

1 November 2017

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