(Q42512972)

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Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

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1 November 2017

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage (English)

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1 November 2017

Huntington's disease

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based on heuristic

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Angela Hodges

3

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Thierry Sengstag

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Thierry Sengstag

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1 November 2017

Charles Kooperberg

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Charles Kooperberg

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Mahmoud A. Pouladi

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1 November 2017

Anthony J Hannan

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Anthony J Hannan

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Michael R. Hayden

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Blair R Leavitt

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Blair R Leavitt

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Stephen Dunnett

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Stephen B Dunnett

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Robert J Ferrante

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Robert J Ferrante

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Richard L M Faull

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22

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Ruth Luthi-Carter

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Ruth Luthi-Carter

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Kristina Becanovic

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Kristina Becanovic

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Andrew D Strand

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Andrew D Strand

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Jang-Ho J Cha

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1 November 2017

author name string

Alexandre Kuhn

1

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Darlene R Goldstein

2

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1 November 2017

Kirupa Sathasivam

9

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1 November 2017

Roger Albin

16

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Peggy Shelbourne

17

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1 November 2017

Mauro Delorenzi

18

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1 November 2017

Sarah J Augood

19

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James M Olson

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Lesley Jones

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publication date

21 May 2007

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Human Molecular Genetics

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16

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15

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1 November 2017

1845-1861

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1 November 2017

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain

1 reference

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Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

1 reference

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Chronology of behavioral symptoms and neuropathological sequela in R6/2 Huntington's disease transgenic mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

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Selective deficits in the expression of striatal-enriched mRNAs in Huntington's disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Loss of mRNA levels, binding and activation of GTP-binding proteins for cannabinoid CB1 receptors in the basal ganglia of a transgenic model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

A Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Neurological abnormalities in a knock-in mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Impaired synaptic plasticity in mice carrying the Huntington's disease mutation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

The Hdh(Q150/Q150) knock-in mouse model of HD and the R6/2 exon 1 model develop comparable and widespread molecular phenotypes

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

The operant serial implicit learning task reveals early onset motor learning deficits in the Hdh knock-in mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Identification of a presymptomatic molecular phenotype in Hdh CAG knock-in mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Regional and cellular gene expression changes in human Huntington's disease brain

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Ontological analysis of gene expression data: current tools, limitations, and open problems

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Discovering statistically significant pathways in expression profiling studies

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Extensions to gene set enrichment

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Transcriptional dysregulation in striatal projection- and interneurons in a mouse model of Huntington's disease: neuronal selectivity and potential neuroprotective role of HAP1.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Normal huntingtin function: an alternative approach to Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Histone deacetylase inhibitors reduce polyglutamine toxicity

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Modulation of nucleosome dynamics in Huntington's disease

1 reference

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21 January 2018

A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

1 reference

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21 January 2018

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

1 reference

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21 January 2018

affy--analysis of Affymetrix GeneChip data at the probe level

1 reference

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21 January 2018

Linear models and empirical bayes methods for assessing differential expression in microarray experiments

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Database resources of the National Center for Biotechnology Information

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM133

21 January 2018

Analyzing gene expression data in terms of gene sets: methodological issues

1 reference

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An empirical comparison of permutation methods for tests of partial regression coefficients in a linear model

1 reference

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21 January 2018

Identifiers

10.1093/HMG/DDM133

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 November 2017

ResearchGate publication ID

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