(Q42442252)

31 October 2017

title

Methotrexate normalizes up-regulated folate pathway genes in rheumatoid arthritis (English)

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Dirkjan van Schaardenburg

31 October 2017

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object named as

Dirkjan van Schaardenburg

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31 October 2017

Marjolein Blits

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31 October 2017

Gerrit Jansen

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31 October 2017

Yehuda G Assaraf

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31 October 2017

Mark A van de Wiel

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31 October 2017

Willem F Lems

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31 October 2017

Mike T Nurmohamed

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31 October 2017

Alexandre E Voskuyl

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31 October 2017

Gert-Jan Wolbink

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31 October 2017

Saskia Vosslamber

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31 October 2017

Cornelis L Verweij

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31 October 2017

publication date

1 November 2013

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31 October 2017

published in

Arthritis & Rheumatology

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31 October 2017

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31 October 2017

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31 October 2017

page(s)

2791-2802

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The pathogenesis of rheumatoid arthritis

31 October 2017

cites work

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Toward a better understanding of methotrexate

21 January 2018

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New therapies for treatment of rheumatoid arthritis

21 January 2018

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Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance

21 January 2018

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Low-dose methotrexate: a mainstay in the treatment of rheumatoid arthritis

21 January 2018

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Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis

21 January 2018

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Methotrexate increases expression of cell cycle checkpoint genes via JNK activation

21 January 2018

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The anti-inflammatory actions of methotrexate are critically dependent upon the production of reactive oxygen species

21 January 2018

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Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells

21 January 2018

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Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation

21 January 2018

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Drug Insight: resistance to methotrexate and other disease-modifying antirheumatic drugs--from bench to bedside

21 January 2018

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Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption

21 January 2018

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Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis

21 January 2018

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Folate receptor beta as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients

21 January 2018

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Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia.

21 January 2018

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Differences in methotrexate and 7-hydroxymethotrexate inhibition of folate-dependent enzymes of purine nucleotide biosynthesis

21 January 2018

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Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates

21 January 2018

1 reference

Effect of genetic polymorphisms in the folate pathway on methotrexate therapy in rheumatic diseases

21 January 2018

1 reference

Clinical pharmacogenetic model to predict response of MTX monotherapy in patients with established rheumatoid arthritis after DMARD failure

21 January 2018

1 reference

Red blood cell methotrexate polyglutamates emerge as a function of dosage intensity and route of administration during pulse methotrexate therapy in rheumatoid arthritis

21 January 2018

1 reference

Methotrexate polyglutamate concentrations are not associated with disease control in rheumatoid arthritis patients receiving long-term methotrexate therapy

21 January 2018

1 reference

Rheumatoid arthritis subtypes identified by genomic profiling of peripheral blood cells: assignment of a type I interferon signature in a subpopulation of patients.

21 January 2018

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The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

21 January 2018

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Assessing the human immune system through blood transcriptomics

21 January 2018

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The Stanford Microarray Database accommodates additional microarray platforms and data formats

21 January 2018

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Significance analysis of microarrays applied to the ionizing radiation response

21 January 2018

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Peripheral blood gene expression profiling in rheumatoid arthritis.

21 January 2018

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Pharmacogenomics of infliximab treatment using peripheral blood cells of patients with rheumatoid arthritis.

21 January 2018

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Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders

21 January 2018

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Getting started in biological pathway construction and analysis.

21 January 2018

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Compartmentalization of Mammalian folate-mediated one-carbon metabolism

21 January 2018

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Involvement of breast cancer resistance protein expression on rheumatoid arthritis synovial tissue macrophages in resistance to methotrexate and leflunomide

21 January 2018

1 reference

ABC drug transporters and immunity: novel therapeutic targets in autoimmunity and cancer

21 January 2018

1 reference

Do snapshot statistics fool us in MTX pharmacogenetic studies in arthritis research?

21 January 2018

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Genetic polymorphisms in key methotrexate pathway genes are associated with response to treatment in rheumatoid arthritis patients

21 January 2018

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Pharmacokinetics of oral methotrexate in patients with rheumatoid arthritis

21 January 2018

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Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis

21 January 2018

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Adalimumab alone and in combination with disease-modifying antirheumatic drugs for the treatment of rheumatoid arthritis in clinical practice: the Research in Active Rheumatoid Arthritis (ReAct) trial

21 January 2018

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Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial

21 January 2018

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Less radiographic progression with adalimumab plus methotrexate versus methotrexate monotherapy across the spectrum of clinical response in early rheumatoid arthritis

21 January 2018

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From methotrexate to pemetrexed and beyond. A review of the pharmacodynamic and clinical properties of antifolates

21 January 2018

1 reference

21 January 2018

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Patterns of interaction between genetic and nongenetic attributes and methotrexate efficacy in rheumatoid arthritis

21 January 2018

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A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset rheumatoid arthritis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ART.38094

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31 October 2017

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