(Q41916176)

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Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model

scientific article published on 4 October 2013

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scholarly article

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Europe PubMed Central

PMC publication ID

14 October 2017

Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model (English)

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Europe PubMed Central

PMC publication ID

14 October 2017

neoplastic stem cells

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Andreas Hildebrandt

8

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14 October 2017

23

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14 October 2017

Ernesto Bockamp

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Ernesto Bockamp

24

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Andreas Trumpp

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4

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Martin Löwer

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PMC publication ID

14 October 2017

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Nina Cabezas-Wallscheid

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14 October 2017

Victoria Eichwald

2

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14 October 2017

Jos de Graaf

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14 October 2017

Hans-Anton Lehr

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14 October 2017

Andreas Kreft

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14 October 2017

Leonid Eshkind

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14 October 2017

Yasmin Abassi

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14 October 2017

Rosario Heck

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14 October 2017

Anna Katharina Dehof

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14 October 2017

Svetlana Ohngemach

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14 October 2017

Rolf Sprengel

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14 October 2017

Simone Wörtge

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14 October 2017

Steffen Schmitt

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14 October 2017

Johannes Lotz

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14 October 2017

Claudius Meyer

17

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14 October 2017

Thomas Kindler

18

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14 October 2017

Dong-Er Zhang

19

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14 October 2017

Bernd Kaina

20

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14 October 2017

John C Castle

21

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14 October 2017

publication date

4 October 2013

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14 October 2017

EMBO Molecular Medicine

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14 October 2017

5

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14 October 2017

12

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14 October 2017

1804-1820

1 reference

Europe PubMed Central

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14 October 2017

Mechanisms of acquired resistance to targeted cancer therapies.

1 reference

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5 June 2018

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

1 reference

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5 June 2018

The evolving concept of cancer and metastasis stem cells

1 reference

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5 June 2018

Recent advances in acute myeloid leukemia stem cell biology

1 reference

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5 June 2018

Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding.

1 reference

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5 June 2018

RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis

1 reference

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The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation

1 reference

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Acute Myeloid Leukemia with the t(8;21) Translocation: Clinical Consequences and Biological Implications

1 reference

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5 June 2018

Common and Overlapping Oncogenic Pathways Contribute to the Evolution of Acute Myeloid Leukemias

1 reference

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Evaluation of gene expression signatures predictive of cytogenetic and molecular subtypes of pediatric acute myeloid leukemia

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Tetracycline-controlled transgene activation using the ROSA26-iM2-GFP knock-in mouse strain permits GFP monitoring of DOX-regulated transgene-expression

1 reference

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5 June 2018

Molecular targeting of aberrant transcription factors in leukemia: strategies for RUNX1/ETO.

1 reference

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5 June 2018

Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

1 reference

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5 June 2018

Characterization of RNA aptamers that disrupt the RUNX1-CBFbeta/DNA complex

1 reference

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5 June 2018

Stem cell concepts renew cancer research

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5 June 2018

Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling

1 reference

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5 June 2018

Conditional transgenic mouse models: from the basics to genome-wide sets of knockouts and current studies of tissue regeneration.

1 reference

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5 June 2018

Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia

1 reference

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5 June 2018

Acute myeloid leukaemia

1 reference

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5 June 2018

The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914523

5 June 2018

Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914523

5 June 2018

Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors

1 reference

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5 June 2018

Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914523

5 June 2018

Of mice and models: improved animal models for biomedical research

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914523

5 June 2018

AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914523

5 June 2018

Genetics of myeloid leukemias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914523

5 June 2018

Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914523

5 June 2018

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914523

5 June 2018

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914523

5 June 2018

Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914523

5 June 2018

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

1 reference

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5 June 2018

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914523

5 June 2018

Persistence of the 8;21 translocation in patients with acute myeloid leukemia type M2 in long-term remission.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914523

5 June 2018

The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3914523

5 June 2018

Stem cell gene expression programs influence clinical outcome in human leukemia.

1 reference

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18 August 2018

High VEGFC expression is associated with unique gene expression profiles and predicts adverse prognosis in pediatric and adult acute myeloid leukemia.

1 reference

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18 August 2018

Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.

1 reference

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Clinical significance of minimal residual disease in patients with t(8;21) acute myeloid leukemia in Japan.

1 reference

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18 August 2018

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1 reference

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18 August 2018

Gene expression profiling of pediatric acute myelogenous leukemia

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18 August 2018

Prognostically useful gene-expression profiles in acute myeloid leukemia.

1 reference

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18 August 2018

In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia

1 reference

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18 August 2018

Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model

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Microarray-based classifiers and prognosis models identify subgroups with distinct clinical outcomes and high risk of AML transformation of myelodysplastic syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/24124051

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Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24124051

12 December 2020

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inferred from PubMed ID database lookup

AML1/ETO fusion mRNA can be detected in remission blood samples of all patients with t(8;21) acute myeloid leukemia after chemotherapy or autologous bone marrow transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24124051

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inferred from PubMed ID database lookup

Detection of t(8;21) by reverse transcriptase polymerase chain reaction in patients in remission of acute myeloid leukaemia type M2 after chemotherapy or bone marrow transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24124051

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based on heuristic

inferred from PubMed ID database lookup

Persistence of multipotent progenitors expressing AML1/ETO transcripts in long-term remission patients with t(8;21) acute myelogenous leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/24124051

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The clinical spectrum of adult acute myeloid leukaemia associated with core binding factor translocations

1 reference

https://pubmed.ncbi.nlm.nih.gov/24124051

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inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/24124051

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/EMMM.201302661

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

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