(Q41951354)

English

Cognitive impairment in folate-deficient rats corresponds to depleted brain phosphatidylcholine and is prevented by dietary methionine without lowering plasma homocysteine.

scientific article published on December 2008

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19022979%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Cognitive impairment in folate-deficient rats corresponds to depleted brain phosphatidylcholine and is prevented by dietary methionine without lowering plasma homocysteine (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19022979%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

phosphatidylcholine

1 reference

based on heuristic

inferred from title

cognitive dysfunction

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based on heuristic

inferred from title

2

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17 January 2020

7

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Jacob Selhub

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17 January 2020

Irwin H. Rosenberg

8

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Irwin H Rosenberg

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17 January 2020

author name string

Aron M Troen

1

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17 January 2020

Natalia A Crivello

3

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17 January 2020

Kristen E D'Anci

4

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17 January 2020

Barbara Shukitt-Hale

5

1 reference

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17 January 2020

Don E Smith

6

1 reference

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17 January 2020

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1 December 2008

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17 January 2020

Journal of Nutrition

1 reference

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17 January 2020

138

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17 January 2020

12

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17 January 2020

2502-2509

1 reference

Europe PubMed Central

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17 January 2020

B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Defects in homocysteine metabolism: diversity among hyperhomocyst(e)inemias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

The many facets of hyperhomocysteinemia: studies from the Framingham cohorts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Trends in serum folate, RBC folate, and circulating total homocysteine concentrations in the United States: analysis of data from National Health and Nutrition Examination Surveys, 1988-1994, 1999-2000, and 2001-2002.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Age-related changes in neutral sphingomyelin-specific phospholipase C activity in striatum, hippocampus, and frontal cortex: implication for sensitivity to stress and inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

The central nervous system in animal models of hyperhomocysteinemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Ademetionine (S-adenosylmethionine) neuropharmacology: implications for drug therapies in psychiatric and neurological disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Brain function in the elderly: role of vitamin B12 and folate.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Homocysteine metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Activity of phosphatidylethanolamine-N-methyltransferase in brain affected by Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Folate nutriture alters choline status of women and men fed low choline diets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Interaction between dietary methionine and methyl donor intake on rat liver betaine-homocysteine methyltransferase gene expression and organization of the human gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Psychomotor and spatial memory performance in aging male Fischer 344 rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Total serum homocysteine in senile dementia of Alzheimer type

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Components of the AIN-93 diets as improvements in the AIN-76A diet

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Dissociation of hippocampal and striatal contributions to spatial navigation in the water maze

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Behavioral and neurochemical changes in folate-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Parallel information processing in the water maze: evidence for independent memory systems involving dorsal striatum and hippocampus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Membrane alterations as causes of impaired signal transduction in Alzheimer's disease and aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Effect of experimental folate deficiency on lipid metabolism in liver and brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Phospholipid Methylation and Biological Signal Transmission

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Two dimensional then layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

An evaluation of spatial information processing in aged rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Synthesis of acetylcholine from choline derived from phosphatidylcholine in a human neuronal cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Effect of dietary methyl group deficiency on folate metabolism in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Effect of choline deficiency on S-adenosylmethionine and methionine concentrations in rat liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Boehringer Mannheim Award lecture. Phosphatidylcholine metabolism: masochistic enzymology, metabolic regulation, and lipoprotein assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Nutritional factors in physical and cognitive functions of elderly people

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Long-term folate deficiency alters folate content and distribution differentially in rat tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Plasma homocysteine in vascular disease and in nonvascular dementia of depressed elderly people

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Choline metabolism as a basis for the selective vulnerability of cholinergic neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Folate deficiency and decreased brain 5-hydroxytryptamine synthesis in man and rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

Lipid composition and metabolism in liver and brain of vitamin B12-deficient rat sucklings

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

beta-Adrenergic receptor agonists increase phospholipid methylation, membrane fluidity, and beta-adrenergic receptor-adenylate cyclase coupling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

5 June 2018

The cognitive impact of nutritional homocysteinemia in apolipoprotein-E deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

18 August 2018

Impaired spatial memory in APP-overexpressing mice on a homocysteinemia-inducing diet.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

18 August 2018

Low folate status is associated with impaired cognitive function and dementia in the Sacramento Area Latino Study on Aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

18 August 2018

Folate deficiency inhibits proliferation of adult hippocampal progenitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

18 August 2018

Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

18 August 2018

Homocysteine versus the vitamins folate, B6, and B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur Studies of Successful Aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

18 August 2018

Plasma folate concentrations are associated with depressive symptoms in elderly Latina women despite folic acid fortification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

18 August 2018

Differential susceptibity of transgenic mice lacking one or both apolipoprotein alleles to folate and vitamin E deprivation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

18 August 2018

Quantification of serum and urinary S-adenosylmethionine and S-adenosylhomocysteine by stable-isotope-dilution liquid chromatography-mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

18 August 2018

Hyperhomocysteinemia due to short-term folate deprivation is related to electron microscopic changes in the rat brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

18 August 2018

Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

18 August 2018

One-year study of spatial memory performance, brain morphology, and cholinergic markers after moderate controlled cortical impact in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

18 August 2018

Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

18 August 2018

Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

18 August 2018

Age-related spatial reference and working memory deficits assessed in the water maze.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

18 August 2018

Spatial learning and motor deficits in aged rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755637

18 August 2018

Effects of choline deficiency and methotrexate treatment upon liver folate content and distribution

1 reference

https://pubmed.ncbi.nlm.nih.gov/19022979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyridoxal-5'-phosphate determination by a sensitive micromethod in human blood, urine and tissues; its relation to cystathioninuria in neuroblastoma and biliary atresia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19022979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Severe folate deficiency causes secondary depletion of choline and phosphocholine in rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/19022979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dietary supplementation with white button mushroom enhances natural killer cell activity in C57BL/6 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19022979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dietary folate and biogenic amines in the CNS

1 reference

https://pubmed.ncbi.nlm.nih.gov/19022979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection

1 reference

https://pubmed.ncbi.nlm.nih.gov/19022979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Choline deficiency and methotrexate treatment induces marked but reversible changes in hepatic folate concentrations, serum homocysteine and DNA methylation rates in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19022979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidant Injury in PC12 Cells—A Possible Model of Calcium “Dysregulation” in Aging: II. Interactions with Membrane Lipids

1 reference

https://pubmed.ncbi.nlm.nih.gov/19022979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospholipid methylation and membrane function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19022979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: findings from the Nun study

1 reference

https://pubmed.ncbi.nlm.nih.gov/19022979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of ageing on folate metabolism in rats fed a long-term folate deficient diet

1 reference

https://pubmed.ncbi.nlm.nih.gov/19022979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is metabolic evidence for vitamin B-12 and folate deficiency more frequent in elderly patients with Alzheimer's disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19022979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dietary folic acid and the activity of brain cholinergic and gamma-aminobutyric acid (GABA) enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19022979

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3945/JN.108.093641

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19022979%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19022979%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19022979%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

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