(Q41692688)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448733%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

review article

1 reference

title

In vitro approaches to predicting drug interactions in vivo (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448733%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448733%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

J S Harmatz

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448733%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

D J Greenblatt

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448733%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

L L von Moltke

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448733%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

J Schmider

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448733%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

C E Wright

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448733%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

language of work or name

English

0 references

publication date

1 January 1998

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448733%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

published in

Biochemical Pharmacology

1 reference

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9 November 2019

volume

1 reference

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9 November 2019

issue

1 reference

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9 November 2019

page(s)

113-122

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448733%20AND%20SRC:MED&resulttype=core&format=json

Human drug metabolism in vitro.

9 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

In vitro approaches can predict human drug metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Recent developments in hepatic drug oxidation. Implications for clinical pharmacokinetics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Human cytochromes P450: problems and prospects

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Human cytochrome P-450 enzymes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

The emerging role of cytochrome P450 3A in psychopharmacology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

P450 enzymes. Inhibition mechanisms, genetic regulation and effects of liver disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Use of in vitro human metabolism studies in drug development. An industrial perspective

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Role of cytochromes P450 in drug metabolism and hepatotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

The human hepatic cytochromes P450 involved in drug metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Fluvoxamine is a potent inhibitor of cytochrome P4501A2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Phenacetin O-deethylation by human liver microsomes in vitro: inhibition by chemical probes, SSRI antidepressants, nefazodone and venlafaxine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Cooperativity in oxidations catalyzed by cytochrome P450 3A4.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Enzyme kinetic modelling as a tool to analyse the behaviour of cytochrome P450 catalysed reactions: application to amitriptyline N-demethylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Midazolam hydroxylation by human liver microsomes in vitro: inhibition by fluoxetine, norfluoxetine, and by azole antifungal agents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Comparative effects of the antimycotic drugs ketoconazole, fluconazole, itraconazole and terbinafine on the metabolism of cyclosporin by human liver microsomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Effects of 'rogue' points on non-linear fitting.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Structural basis of selective cytochrome P450 inhibition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Metabolism of drugs by cytochrome P450 3A isoforms. Implications for drug interactions in psychopharmacology.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Commentary: a physiological approach to hepatic drug clearance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Inhibition of human CYP3A catalyzed 1'-hydroxy midazolam formation by ketoconazole, nifedipine, erythromycin, cimetidine, and nizatidine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

A potentially hazardous interaction between erythromycin and midazolam

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Inhibition of sulfamethoxazole hydroxylamine formation by fluconazole in human liver microsomes and healthy volunteers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Methods of determining plasma and tissue binding of drugs. Pharmacokinetic consequences

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Binding of drugs to tissues

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Physical partitioning as the major source of metoprolol uptake by hepatic microsomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Comparison of the hepatic uptake clearances of fifteen drugs with a wide range of membrane permeabilities in isolated rat hepatocytes and perfused rat livers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Prediction of drug distribution in vivo on the basis of in vitro binding data

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Comparison between in-vivo and in-vitro tissue-to-plasma unbound concentration ratios (Kp,f) of quinidine in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

In vitro and in vivo evaluation of the tissue-to-blood partition coefficient for physiological pharmacokinetic models

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Inhibition of human cytochrome P450-3A isoforms by fluoxetine and norfluoxetine: in vitro and in vivo studies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Thioridazine enantiomers in human tissues

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Two fatalities involving haloperidol

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Tissue distribution of diazepam and its metabolite desmethyldiazepam: a human autopsy study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

The Determination of the Triazolobenzodiazepine Triazolam in Post Modem Samples

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Distribution of sertraline in postmortem cases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Interpretation of blood and tissue concentrations in fatal self-ingested overdose involving amitriptyline: an update (1978-1979)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Clozapine cases with fatal, toxic or therapeutic concentrations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Distribution of trimipramine and its major metabolites in a fatal overdose case

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Postmortem release of amitriptyline from the lungs; a mechanism of postmortem drug redistribution

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Site dependence of drug concentrations in postmortem blood--a case study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Diffusion as a mechanism of postmortem drug redistribution: an experimental study in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Clinical significance of pharmacokinetic models of hepatic elimination

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

First-pass elimination. Basic concepts and clinical consequences

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

First-pass metabolism of midazolam by the human intestine.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine*

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Oral azole drugs as systemic antifungal therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Determination of ketoconazole in the plasma, liver, lung and adrenal of the rat by high-performance liquid chromatography

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Disposition of azole antifungal agents. I. Nonlinearities in ketoconazole clearance and binding in rat liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Oral triazolam is potentially hazardous to patients receiving systemic antimycotics ketoconazole or itraconazole

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

In vitro prediction of the terfenadine-ketoconazole pharmacokinetic interaction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Inhibitors of alprazolam metabolism in vitro: effect of serotonin-reuptake-inhibitor antidepressants, ketoconazole and quinidine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Comparison of alprazolam plasma levels in normal Asian and Caucasian male volunteers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Pharmacokinetics and pharmacodynamics of alprazolam after oral and IV administration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Inhibition of desmethylimipramine 2-hydroxylation by drugs in human liver microsomes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Studies on cytochrome P450 responsible for oxidative metabolism of imipramine in human liver microsomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Inhibition of alprazolam and desipramine hydroxylation in vitro by paroxetine and fluvoxamine: comparison with other selective serotonin reuptake inhibitor antidepressants

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

The clinician and drug interactions--an update

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Quantification and mechanism of the fluoxetine and tricyclic antidepressant interaction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Desipramine Pharmacokinetics When Coadministered With Paroxetine or Sertraline in Extensive Metabolizers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Inhibition by paroxetine of desipramine metabolism in extensive but not in poor metabolizers of sparteine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Pharmacokinetic pharmacodynamic evaluation of the combined administration of alprazolam and fluoxetine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Fluoxetine impairs clearance of alprazolam but not of clonazepam

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

A pharmacokinetic and pharmacodynamic evaluation of the combined administration of alprazolam and fluvoxamine.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Inhibition of terfenadine metabolism in vitro by azole antifungal agents and by selective serotonin reuptake inhibitor antidepressants: relation to pharmacokinetic interactions in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

Selective serotonin reuptake inhibitors and theophylline metabolism in human liver microsomes: potent inhibition by fluvoxamine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2897%2900239-6

10.1016/S0006-2952(97)00239-6

7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448733%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9448733%20AND%20SRC:MED&resulttype=core&format=json