(Q41034962)

25 September 2017

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title

Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics (English)

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25 September 2017

M Yamazaki

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25 September 2017

H Suzuki

series ordinal

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25 September 2017

Y Sugiyama

series ordinal

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25 September 2017

publication date

1 April 1996

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25 September 2017

published in

Pharmaceutical Research

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25 September 2017

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25 September 2017

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25 September 2017

page(s)

497-513

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Conjugative metabolism of 4-methylumbelliferone in the rat liver: verification of the sequestration process in multiple indicator dilution experiments

25 September 2017

cites work

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12 December 2020

Effect of albumin on hepatic uptake of warfarin in normal and analbuminemic mutant rats: analysis by multiple indicator dilution method

1 reference

12 December 2020

Construction of a physiologically based pharmacokinetic model to describe the hepatobiliary excretion process of ligands: quantitative estimation of intracellular diffusion.

1 reference

12 December 2020

Induction of hepatic P-glycoprotein enhances biliary excretion of vincristine in rats

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12 December 2020

Isolation of a sulfobromophthalein-binding protein from hepatocyte plasma membrane

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12 December 2020

Influence of Cl- on organic anion transport in short-term cultured rat hepatocytes and isolated perfused rat liver

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12 December 2020

Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport

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12 December 2020

Mechanism of glutathione S-conjugate transport in canalicular and basolateral rat liver plasma membranes

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12 December 2020

Transport of dibromosulphthalein by isolated rat hepatocytes

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12 December 2020

Two different mRNAs from rat liver code for the transport of bumetanide and taurocholate in Xenopus laevis oocytes

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12 December 2020

Expression cloning of a rat liver Na(+)-independent organic anion transporter

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12 December 2020

Bilitranslocase and sulfobromophthalein/bilirubin-binding protein are both involved in the hepatic uptake of organic anions.

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12 December 2020

Transport polarity of hepatocytes

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12 December 2020

Effect of various organic anions on the plasma disappearance of 1-anilino-8-naphthalene sulfonate

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12 December 2020

Biliary transport of glutathione S-conjugate by rat liver canalicular membrane vesicles

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12 December 2020

Different relationships between cellular ATP and hepatic uptake among taurocholate, cholate, and organic anions.

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12 December 2020

ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates

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12 December 2020

Transport of organic anions in the liver. An update on bile acid, fatty acid, monocarboxylate, anionic amino acid, cholephilic organic anion, and anionic drug transport.

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12 December 2020

Functional reconstitution of ATP-dependent transporters from the solubilized hepatocyte canalicular membrane.

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12 December 2020

Biochemistry of multidrug resistance mediated by the multidrug transporter

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12 December 2020

A dispersion model of hepatic elimination: 2. Steady-state considerations-influence of hepatic blood flow, binding within blood, and hepatocellular enzyme activity

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12 December 2020

Different biliary excretion systems for glucuronide and sulfate of a model compound; study using Eisai hyperbilirubinemic rats.

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12 December 2020

The 3-methylcholanthrene-inducible UDP-glucuronosyltransferase deficiency in the hyperbilirubinemic rat (Gunn rat) is caused by a -1 frameshift mutation

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12 December 2020

On the uptake of materials by the intact liver. The transport and net removal of galactose

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12 December 2020

Rat liver canalicular membrane vesicles. Isolation and topological characterization

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12 December 2020

Uptake of organic anions by isolated rat hepatocytes. A classification in terms of ATP-dependency

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12 December 2020

Na(+)-independent multispecific anion transporter mediates active transport of pravastatin into rat liver.

1 reference

12 December 2020

Two distinct mechanisms for bilirubin glucuronide transport by rat bile canalicular membrane vesicles. Demonstration of defective ATP-dependent transport in rats (TR-) with inherited conjugated hyperbilirubinemia

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12 December 2020

Molecular basis of multiple UDP-glucuronosyltransferase isoenzyme deficiencies in the hyperbilirubinemic rat (Gunn rat)

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12 December 2020

The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

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12 December 2020

ATP/Mg2+-dependent cardiac transport system for glutathione S-conjugates. A study using rat heart sarcolemma vesicles

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12 December 2020

Role of plasma membrane ligand-binding proteins in the hepatocellular uptake of albumin-bound organic anions.

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12 December 2020

Biliary excretion of bile acid conjugates in a hyperbilirubinemic mutant sprague-dawley rat

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12 December 2020

Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes

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12 December 2020

Kinetics of metabolite formation and elimination in the perfused rat liver preparation: differences between the elimination of preformed acetaminophen and acetaminophen formed from phenacetin

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12 December 2020

GS-X pump is functionally overexpressed in cis-diamminedichloroplatinum (II)-resistant human leukemia HL-60 cells and down-regulated by cell differentiation.

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12 December 2020

The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles.

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12 December 2020

Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

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12 December 2020

Characterization of the ATP-dependent leukotriene C4 export carrier in mastocytoma cells

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12 December 2020

Membrane potential-dependent and carrier-mediated transport of cefpiramide, a cephalosporin antibiotic, in canalicular rat liver plasma membrane vesicles

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12 December 2020

Commentary: a physiological approach to hepatic drug clearance

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12 December 2020

Structural and functional polarity of canalicular and basolateral plasma membrane vesicles isolated in high yield from rat liver

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12 December 2020

Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

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12 December 2020

Organic anion-transporting ATPase of rat liver. I. Purification, photoaffinity labeling, and regulation by phosphorylation

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12 December 2020

Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

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12 December 2020

Hereditary defect of hepatobiliary cysteinyl leukotriene elimination in mutant rats with defective hepatic anion excretion

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12 December 2020

Clearance concepts in pharmacokinetics

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12 December 2020

Role of ligandin in transfer of bilirubin from plasma into liver

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12 December 2020

ABC Transporters: From Microorganisms to Man

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12 December 2020

Organic anion-transporting ATPase of rat liver. II. Functional reconstitution of active transport and regulation by phosphorylation

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12 December 2020

Glutathione S-conjugate transport using inside-out vesicles from human erythrocytes

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12 December 2020

Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system

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12 December 2020

Kinetics of hepatic transport of 4-methylumbelliferone in rats. Analysis by multiple indicator dilution method

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12 December 2020

Multiple systems for the biliary excretion of organic anions in rats: liquiritigenin conjugates as model compounds

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12 December 2020

Role of chloride and intracellular pH on the activity of the rat hepatocyte organic anion transporter

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12 December 2020

Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats

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12 December 2020

The ATP-dependent glutathione S-conjugate export pump

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12 December 2020

ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein.

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12 December 2020

Multiple transport systems for organic anions across the bile canalicular membrane

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12 December 2020

Kinetic analysis of hepatobiliary transport of vincristine in perfused rat liver. Possible roles of P-glycoprotein in biliary excretion of vincristine

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12 December 2020

Multiple canalicular transport mechanisms for glutathione S-conjugates. Transport on both ATP- and voltage-dependent carriers

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12 December 2020

Dose-dependent hepatic handling of l-propranolol determined by multiple indicator dilution method: influence of tissue binding of l-propranolol on its hepatic elimination

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12 December 2020

Comparison of the hepatic uptake clearances of fifteen drugs with a wide range of membrane permeabilities in isolated rat hepatocytes and perfused rat livers

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12 December 2020

Kinetic analysis of hepatobiliary transport for conjugated metabolites in the perfused liver of mutant rats (EHBR) with hereditary conjugated hyperbilirubinemia

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12 December 2020

Carrier-mediated transport in the hepatic distribution and elimination of drugs, with special reference to the category of organic cations

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12 December 2020

Kinetic analysis of hepatobiliary transport of organic anions in Eisai hyperbilirubinemic mutant rats

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12 December 2020

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

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12 December 2020

Hepatobiliary transport of glutathione and glutathione conjugate in rats with hereditary hyperbilirubinemia

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12 December 2020

Evidence for the presence of a phosphatidylcholine translocator in isolated rat liver canalicular plasma membrane vesicles

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12 December 2020

Evaluation of the uptake of pravastatin by perfused rat liver and primary cultured rat hepatocytes

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12 December 2020

Identifiers

DOI

10.1023/A:1016077517241

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25 September 2017

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