(Q410798)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O76074

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O76074

GAF-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O76074

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, protein family

1 reference

HD/PDEase domain, protein family

1 reference

GAF domain, protein family

1 reference

3'5'-cyclic nucleotide phosphodiesterase, conserved site, protein family

1 reference

imported from Wikimedia project

image

Protein PDE5A PDB 3BJC.png
961 × 751; 464 KB

1 reference

Spanish Wikipedia

Wikimedia import URL

https://es.wikipedia.org/w/index.php?title=Fosfodiesterasa_5&oldid=119995354

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

1 reference

8 April 2019

3',5'-cyclic-nucleotide phosphodiesterase activity

Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

cGMP binding

Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76074&geneProductId=UniProtKB:O76074

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76074&geneProductId=UniProtKB:O76074

21 June 2018

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76074&geneProductId=UniProtKB:O76074

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

1 reference

8 April 2019

cyclic-nucleotide phosphodiesterase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

catalytic activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

1 reference

8 April 2019

phosphoric diester hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

1 reference

8 April 2019

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

1 reference

8 April 2019

protein binding

IPI

1 reference

8 April 2019

Compartmentation and compartment-specific regulation of PDE5 by protein kinase G allows selective cGMP-mediated regulation of platelet functions

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

3',5'-cyclic-GMP phosphodiesterase activity

IPI

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76074&geneProductId=UniProtKB:O76074

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76074&geneProductId=UniProtKB:O76074

21 June 2018

21 June 2018

Differentiation of human monocytes in vitro with granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor produces distinct changes in cGMP phosphodiesterase expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76074&geneProductId=UniProtKB:O76074

cGMP binding

Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

3',5'-cyclic-GMP phosphodiesterase activity

IBA

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76074&geneProductId=UniProtKB:O76074

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76074&geneProductId=UniProtKB:O76074

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76074&geneProductId=UniProtKB:O76074

1 January 2018

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76074&geneProductId=UniProtKB:O76074

3',5'-cyclic-GMP phosphodiesterase activity

IBA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

positive regulation of MAP kinase activity

IBA

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

cGMP metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

positive regulation of cardiac muscle hypertrophy

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

cGMP catabolic process

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76074&geneProductId=UniProtKB:O76074

3 references

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76074&geneProductId=UniProtKB:O76074

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76074&geneProductId=UniProtKB:O76074

1 January 2018

negative regulation of T cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

positive regulation of oocyte development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

1 reference

8 April 2019

relaxation of cardiac muscle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

1 reference

8 April 2019

negative regulation of cardiac muscle contraction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

regulation of nitric oxide mediated signal transduction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76074

physically interacts with

1 reference

7399

17 August 2016

1 reference

5225

17 August 2016

1 reference

5270

17 August 2016

1 reference

4743

17 August 2016

1 reference

7299

17 August 2016

1 reference

7320

17 August 2016

1 reference

2919

English

object of statement has role

17 August 2016

sildenafil

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL192

ibudilast

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL19449

gisadenafil

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1928262

EC enzyme number

3.1.4.35

1 reference

imported from Wikimedia project

Spanish Wikipedia

Gene Atlas image

PBB GE PDE5A 206757 at fs.png
732 × 530; 12 KB

0 references

exact match

http://purl.uniprot.org/uniprot/O76074

1 reference

https://docs.openalex.org/download-snapshot/snapshot-data-format

Identifiers.org

Commons category

Phosphodiesterase 5

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Identifiers

1 reference

30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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13 November 2019

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28 October 2013

Microsoft Academic ID

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26 January 2022

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4 August 2016

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4 August 2016