(Q41041971)

26 September 2017

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title

Perspectives in pharmacokinetics. Physiologically based pharmacokinetic modeling as a tool for drug development (English)

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26 September 2017

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S B Charnick

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26 September 2017

R Kawai

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26 September 2017

J R Nedelman

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26 September 2017

M Lemaire

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26 September 2017

W Niederberger

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26 September 2017

H Sato

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26 September 2017

publication date

1 April 1995

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Journal of Pharmacokinetics and Pharmacodynamics

26 September 2017

published in

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26 September 2017

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26 September 2017

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26 September 2017

page(s)

217-229

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Feasibility of developing a neural network for prediction of human pharmacokinetic parameters from animal data

26 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FBF02354273

Neural networks in pharmacodynamic modeling. Is current modeling practice of complex kinetic systems at a dead end?

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

Application of neural computing in pharmaceutical product development

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

Quantitative structure-activity study on human pharmacokinetic parameters of benzodiazepines using the graph theoretical approach.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

Pharmacokinetics and expert systems as aids for risk assessment in reproductive toxicology

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

Interspecies scaling and comparisons in drug development and toxicokinetics

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

Physiologic pharmacokinetic modeling

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

Physiologically Based Pharmacokinetic Modeling: Principles and Applications

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

Physiological pharmacokinetics.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

Physiologic pharmacokinetic models and interanimal species scaling

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

Physiologic pharmacokinetic models: relevance, experience, and future trends

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

Physiological basis of multicompartmental models of drug distribution

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

A review of the applications of physiologically based pharmacokinetic modeling

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

Preliminary Model for Methotrexate Pharmacokinetics

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

Thiopental Pharmacokinetics

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

Man versus beast: pharmacokinetic scaling in mammals

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

Physiological pharmacokinetic modelling

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

Extrapolation of animal toxicity to humans: interspecies comparisons in drug development

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

Physiological pharmacokinetics and cancer risk assessment.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

Biologically based pharmacodynamic models: tools for toxicological research and risk assessment

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

Use of physiologically based pharmacokinetic models to establish biological exposure indexes

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

Development and utilization of physiologically based pharmacokinetic models for toxicological applications

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

Implications of pharmacokinetic modeling in risk assessment analysis

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

Engineering targeted in vivo drug delivery. I. The physiological and physicochemical principles governing opportunities and limitations

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

A multi-organ, axially distributed model of capillary permeability for a magnetic resonance imaging contrast agent

21 January 2018

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Physiological modeling of disposition of potential tumor-imaging radiopharmaceuticals in tumor-bearing mice

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

A kinetic model for 99mTc-DMSA in the rat.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

Physiologically based pharmacokinetic and pharmacodynamic model for the inhibition of acetylcholinesterase by diisopropylfluorophosphate

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

Precision and sensitivity of pharmacokinetic models for cancer risk assessment: tetrachloroethylene in mice, rats, and humans

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

Sensitivity analysis for physiologically based pharmacokinetic models.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

Plasma protein binding of drugs in pregnancy and in neonates

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02354273

Plasma protein binding of drugs in the elderly

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02354273

Noninvasive measurement of portal venous blood flow in patients with cirrhosis: effects of physiological and pharmacological stimuli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02354273

Evaluation of hepatic function using the pharmacokinetics of a therapeutically administered drug. Application to the immunosuppressant cyclosporin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02354273

Simultaneous administration of multiple model substrates to assess hepatic drug clearance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02354273

Physiological pharmacokinetic modeling of cis-dichlorodiammineplatinum(II) (DDP) in several species

21 January 2018

1 reference

12 December 2020

Variability in biological monitoring of solvent exposure. I. Development of a population physiological model

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12 December 2020

Physiological pharmacokinetic parameters for cis-dichlorodiammineplatinum(II) (DDP) in the mouse

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12 December 2020

Noninvasive, quantitative determination of muscle blood flow in man by a combination of venous-occlusion plethysmography and computed tomography

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12 December 2020

An electric analogue for uptake and exchange of inert gases and other agents.

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12 December 2020

Estimation of hepatic blood flow in branches of hepatic vessels utilizing a noninvasive, duplex Doppler method

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12 December 2020

Methotrexate Pharmacokinetics

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12 December 2020

Physiologically-based pharmacokinetic models in risk and exposure assessment

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12 December 2020

Physiological pharmacokinetic model of adriamycin delivered via magnetic albumin microspheres in the rat

1 reference

12 December 2020

Physiological pharmacokinetic models: principles, applications, limitations and outlook.

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12 December 2020

Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125

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12 December 2020

The new cyclosporine derivative, SDZ IMM 125: in vitro and in vivo pharmacologic effects

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12 December 2020

Research utility of noninvasive methods for measurement of cardiac output

1 reference

12 December 2020

Physiological pharmacokinetic and pharmacodynamic model of physostigmine in the rat.

1 reference

12 December 2020

Pharmacokinetics of monoclonal immunoglobulin G1, F(ab')2, and Fab' in mice

1 reference

12 December 2020

Efficiency of drug targeting: steady-state considerations using a three-compartment model

1 reference

12 December 2020

Noninvasive quantification of hepatic arterial blood flow with nitrogen-13-ammonia and dynamic positron emission tomography

1 reference

12 December 2020

Physiologically based pharmacokinetics of radioiodinated human beta-endorphin in rats. An application of the capillary membrane-limited model.

1 reference

12 December 2020

A graph-theoretic approach to modeling metabolic pathways

1 reference

12 December 2020

Physiological pharmacokinetic models: some aspects of theory, practice and potential

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12 December 2020

Identifiers

DOI

10.1007/BF02354273

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26 September 2017

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