(Q40969918)

25 September 2017

Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors (English)

1 reference

25 September 2017

Meenhard Herlyn

1 reference

25 September 2017

Keith T Flaherty

1 reference

25 September 2017

Clemens Krepler

1 reference

25 September 2017

Tara C Gangadhar

1 reference

25 September 2017

Jennifer A Wargo

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25 September 2017

Gordon B Mills

1 reference

25 September 2017

Giorgos C Karakousis

1 reference

25 September 2017

Patricia Brafford

1 reference

25 September 2017

Sergio Randell

1 reference

25 September 2017

Batool Shannan

1 reference

25 September 2017

Katrin Sproesser

1 reference

25 September 2017

Omotayo Ope

1 reference

25 September 2017

Dario C Altieri

1 reference

25 September 2017

Dennie T Frederick

1 reference

25 September 2017

Gao Zhang

1 reference

25 September 2017

Lawrence Wu

1 reference

25 September 2017

Zhi Wei

1 reference

25 September 2017

Satish Srinivasan

1 reference

25 September 2017

Young Chan Chae

1 reference

25 September 2017

Xiaowei Xu

1 reference

25 September 2017

Harry Choi

1 reference

25 September 2017

Elaida Dimwamwa

1 reference

25 September 2017

Devraj Basu

1 reference

25 September 2017

Dongmei Zhang

1 reference

25 September 2017

Manti Guha

1 reference

25 September 2017

Min Xiao

1 reference

25 September 2017

Wei Xu

1 reference

25 September 2017

Jephrey Liu

1 reference

25 September 2017

Lynn M Schuchter

1 reference

25 September 2017

Ravi K Amaravadi

1 reference

25 September 2017

Mengnan Gu

1 reference

25 September 2017

Caiyue Xu

1 reference

25 September 2017

Abheek Ghosh

1 reference

25 September 2017

Weiting Xu

1 reference

25 September 2017

Tian Tian

1 reference

25 September 2017

Jie Zhang

1 reference

25 September 2017

Shijie Zha

1 reference

25 September 2017

Qin Liu

1 reference

25 September 2017

Ashani Weeraratna

1 reference

25 September 2017

Michael A Davies

1 reference

25 September 2017

Narayan G Avadhani

1 reference

25 September 2017

Yiling Lu

1 reference

25 September 2017

language of work or name

English

0 references

publication date

4 April 2016

1 reference

Journal of Clinical Investigation

25 September 2017

1 reference

25 September 2017

126

1 reference

25 September 2017

1 reference

25 September 2017

1834-1856

1 reference

Genomic Classification of Cutaneous Melanoma

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Interferon α/β Enhances the Cytotoxic Response of MEK Inhibition in Melanoma

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Inhibition of mTORC1/2 overcomes resistance to MAPK pathway inhibitors mediated by PGC1α and oxidative phosphorylation in melanoma

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Landscape of the mitochondrial Hsp90 metabolome in tumours

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Control of tumor bioenergetics and survival stress signaling by mitochondrial HSP90s

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Improved survival with MEK inhibition in BRAF-mutated melanoma

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Improved survival with vemurafenib in melanoma with BRAF V600E mutation

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Hallmarks of Cancer: The Next Generation

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Integrative genome comparison of primary and metastatic melanomas

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

The accessory subunit of mitochondrial DNA polymerase gamma determines the DNA content of mitochondrial nucleoids in human cultured cells

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Treatment of metastatic melanoma: an overview

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Transcriptional regulatory circuits controlling mitochondrial biogenesis and function

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Mutations of the BRAF gene in human cancer

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Increased mitochondrial oxidative stress in the Sod2 (+/-) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

The mitochondrial chaperonin hsp60 is required for its own assembly

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

Mitochondrial transcription factor A regulates mtDNA copy number in mammals

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855947

19 August 2018

Identifiers

DOI

10.1172/JCI82661

1 reference

25 September 2017

1 reference

25 September 2017

PubMed publication ID

27043285

1 reference