(Q40954121)

25 September 2017

title

Activation of an MDM2-specific caspase by p53 in the absence of apoptosis (English)

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25 September 2017

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25 September 2017

B Fodera

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25 September 2017

L Chen

series ordinal

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25 September 2017

W Lu

series ordinal

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25 September 2017

J Chen

series ordinal

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25 September 2017

language of work or name

English

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publication date

1 May 1999

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Journal of Biological Chemistry

25 September 2017

published in

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25 September 2017

volume

274

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25 September 2017

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25 September 2017

page(s)

15271-15277

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DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways

25 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis

21 January 2018

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Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

21 January 2018

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Essential role for p53-mediated transcription in E1A-induced apoptosis

21 January 2018

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p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

21 January 2018

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Induction of apoptosis in HeLa cells by trans-activation-deficient p53

21 January 2018

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

Mdm2 promotes the rapid degradation of p53

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

Regulation of p53 stability by Mdm2

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

The p53-mdm-2 autoregulatory feedback loop

21 January 2018

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

1 reference

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Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

Genetic determinants of p53-induced apoptosis and growth arrest

21 January 2018

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WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

21 January 2018

1 reference

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Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

Death receptors: signaling and modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

Proteolytic Cleavage of the mdm2 Oncoprotein during Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

Amplification of a gene encoding a p53-associated protein in human sarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

Suppression of human colorectal carcinoma cell growth by wild-type p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

Mapping of the p53 and mdm-2 Interaction Domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

p53 facilitates pRb cleavage in IL-3-deprived cells: novel pro-apoptotic activity of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

Tumor necrosis factor-induced apoptosis stimulates p53 accumulation and p21WAF1 proteolysis in ME-180 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

Identification of the MDM2 oncoprotein as a substrate for CPP32-like apoptotic proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

A 60 kd MDM2 isoform is produced by caspase cleavage in non-apoptotic tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

Effects of tumor necrosis factor-alpha on antimitogenicity and cell cycle-related proteins in MCF-7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

Activation of caspase-3-like enzymes in non-apoptotic T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.21.15271

21 January 2018

Identifiers

DOI

10.1074/JBC.274.21.15271

1 reference

25 September 2017

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