(Q40952922)

25 September 2017

title

LRRC59 Regulates Trafficking of Nucleic Acid-Sensing TLRs from the Endoplasmic Reticulum via Association with UNC93B1. (English)

1 reference

25 September 2017

main subject

endoplasmic reticulum

0 references

0 references

Chikashi Obuse

1 reference

25 September 2017

Megumi Tatematsu

1 reference

25 September 2017

Kenji Funami

1 reference

25 September 2017

Noriko Ishii

1 reference

25 September 2017

Tsukasa Seya

1 reference

25 September 2017

Misako Matsumoto

1 reference

25 September 2017

language of work or name

English

0 references

publication date

14 October 2015

1 reference

25 September 2017

published in

Journal of Immunology

1 reference

25 September 2017

volume

195

1 reference

25 September 2017

1 reference

25 September 2017

page(s)

4933-4942

1 reference

Decoding the patterns of self and nonself by the innate immune system

25 September 2017

cites work

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

A cell biological view of Toll-like receptor function: regulation through compartmentalization.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

Trafficking of endosomal Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

Cleaved/associated TLR3 represents the primary form of the signaling receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

Essential role for Toll-like receptor 7 (TLR7)-unique cysteines in an intramolecular disulfide bond, proteolytic cleavage and RNA sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

Endosomal localization of TLR8 confers distinctive proteolytic processing on human myeloid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

UNC93B1 physically associates with human TLR8 and regulates TLR8-mediated signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

UNC93B1 mediates differential trafficking of endosomal TLRs

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnα1 and Kpnβ1.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

Leucine-rich repeat-containing protein 59 mediates nuclear import of cancerous inhibitor of PP2A in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

TLR9 is localized in the endoplasmic reticulum prior to stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

Toll-like receptors in systemic autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

TLR8 deficiency leads to autoimmunity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

RNA recognition by human TLR8 can lead to autoimmune inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

Proteolytic processing regulates Toll-like receptor 3 stability and endosomal localization

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

Cell-specific TLR9 trafficking in primary APCs of transgenic TLR9-GFP mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

Acidic amino acid residues in the juxtamembrane region of the nucleotide-sensing TLRs are important for UNC93B1 binding and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

Roles of the cleaved N-terminal TLR3 fragment and cell surface TLR3 in double-stranded RNA sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

Subcellular localization of Toll-like receptor 3 in human dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1501305

21 January 2018

Identifiers

DOI

10.4049/JIMMUNOL.1501305

1 reference

25 September 2017

1 reference