(Q40776570)

PubMed publication ID

11588178

23 September 2017

title

Induction of alpha-synuclein aggregation by intracellular nitrative insult (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6763872&resulttype=core&format=json

12 May 2020

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6763872&resulttype=core&format=json

12 May 2020

E Paxinou

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6763872&resulttype=core&format=json

12 May 2020

Q Chen

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6763872&resulttype=core&format=json

12 May 2020

M Weisse

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6763872&resulttype=core&format=json

12 May 2020

B I Giasson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6763872&resulttype=core&format=json

12 May 2020

S M Rueter

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6763872&resulttype=core&format=json

12 May 2020

J Q Trojanowski

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6763872&resulttype=core&format=json

12 May 2020

V M Lee

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6763872&resulttype=core&format=json

12 May 2020

H Ischiropoulos

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6763872&resulttype=core&format=json

12 May 2020

language of work or name

English

0 references

publication date

1 October 2001

1 reference

PubMed publication ID

11588178

23 September 2017

published in

Journal of Neuroscience

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12 May 2020

volume

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12 May 2020

issue

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12 May 2020

page(s)

8053-8061

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describes a project that uses

12 May 2020

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6763872/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity

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Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity

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Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease

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Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult

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Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation.

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Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice

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Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies

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Cysteine proteinase inhibitors and ras gene products share the same biological activities including transforming activity toward NIH3T3 mouse fibroblasts and the differentiation-inducing activity toward PC12 rat pheochromocytoma cells

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Degradation of alpha-synuclein by proteasome

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Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o'-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson's disease.

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Role of cytochrome c as a stimulator of alpha-synuclein aggregation in Lewy body disease

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Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

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Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections

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Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway

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A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease

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alpha-synuclein promotes mitochondrial deficit and oxidative stress

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Two distinct mechanisms of nitric oxide-mediated neuronal cell death show thiol dependency

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Neuropathology in mice expressing human alpha-synuclein

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Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro

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Cold-induced brain edema and infarction are reduced in transgenic mice overexpressing CuZn-Superoxide dismutase

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The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity

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Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

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Protein nitration in Parkinson's disease

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Intraneuronal filamentous tau protein and alpha-synuclein deposits in neurodegenerative diseases

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A beta-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line

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Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

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Synergistic interactions between NADPH-cytochrome P-450 reductase, paraquat, and iron in the generation of active oxygen radicals

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Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

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Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity

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12 December 2020

Enhanced vulnerability to oxidative stress by alpha-synuclein mutations and C-terminal truncation

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12 December 2020

[38] Detection of reactive nitrogen species using 2,7-dichlorodihydrfluorescein and dihydrorhodamine 123

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Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies

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The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation. A novel mechanism of toxicity

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Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

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12 December 2020

Kinetics of peroxynitrite reaction with amino acids and human serum albumin

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12 December 2020

Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

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12 December 2020

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

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12 December 2020

Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Peroxynitrite-mediated oxidation of dihydrorhodamine 123

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons

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12 December 2020

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

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12 December 2020

Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

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12 December 2020

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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10.1523/JNEUROSCI.21-20-08053.2001

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6763872&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6763872&resulttype=core&format=json

12 May 2020

PubMed publication ID

11588178

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6763872&resulttype=core&format=json