(Q40619026)

English

The γ-secretase cleavage product of polycystin-1 regulates TCF and CHOP-mediated transcriptional activation through a p300-dependent mechanism

scientific article published on 15 December 2011

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scholarly article

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Europe PubMed Central

PMC publication ID

22 September 2017

The γ-secretase cleavage product of polycystin-1 regulates TCF and CHOP-mediated transcriptional activation through a p300-dependent mechanism (English)

1 reference

Europe PubMed Central

PMC publication ID

22 September 2017

author name string

David Merrick

1

1 reference

Europe PubMed Central

PMC publication ID

22 September 2017

Hannah Chapin

2

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Europe PubMed Central

PMC publication ID

22 September 2017

Julie E Baggs

3

1 reference

Europe PubMed Central

PMC publication ID

22 September 2017

Zhiheng Yu

4

1 reference

Europe PubMed Central

PMC publication ID

22 September 2017

Stefan Somlo

5

1 reference

Europe PubMed Central

PMC publication ID

22 September 2017

Zhaoxia Sun

6

1 reference

Europe PubMed Central

PMC publication ID

22 September 2017

John B Hogenesch

7

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Europe PubMed Central

PMC publication ID

22 September 2017

Michael J Caplan

8

1 reference

Europe PubMed Central

PMC publication ID

22 September 2017

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publication date

15 December 2011

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Europe PubMed Central

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22 September 2017

number of pages

14

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Developmental Cell

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Europe PubMed Central

PMC publication ID

22 September 2017

22

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Europe PubMed Central

PMC publication ID

22 September 2017

1

1 reference

Europe PubMed Central

PMC publication ID

22 September 2017

197-210

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Europe PubMed Central

PMC publication ID

22 September 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3264829/fullTextXML

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inferred from PubMed Central ID database lookup

Polycystin-1 regulates STAT activity by a dual mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

T-cell factor/β-catenin activity is suppressed in two different models of autosomal dominant polycystic kidney disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

Regulated Intramembrane Proteolysis: Signaling Pathways and Biological Functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

Polycystic kidney disease: Pathogenesis and potential therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

The cell biology of polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

Polycystin-1 surface localization is stimulated by polycystin-2 and cleavage at the G protein-coupled receptor proteolytic site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

The ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation

1 reference

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22 September 2017

Phenotypic analysis of images of zebrafish treated with Alzheimer's gamma-secretase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

Polycystin-1 C-terminal cleavage is modulated by polycystin-2 expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

Notch signaling: the core pathway and its posttranslational regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

Gene expression profiling identifies a role for CHOP during inhibition of the mitochondrial respiratory chain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

Nuclear signalling by tumour-associated antigen EpCAM

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

Polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

Substrate specificity of gamma-secretase and other intramembrane proteases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

A coactivator trap identifies NONO (p54nrb) as a component of the cAMP-signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

Phospho-regulation of Beta-catenin adhesion and signaling functions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

PKD1 inhibits cancer cells migration and invasion via Wnt signaling pathway in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

CBP/p300 are bimodal regulators of Wnt signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

The polycystin 1-C-terminal fragment stimulates ERK-dependent spreading of renal epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

Roles of CHOP/GADD153 in endoplasmic reticulum stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

Presenilin-dependent "gamma-secretase" processing of deleted in colorectal cancer (DCC)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

Identification of a promoter-specific transcriptional activation domain at the C terminus of the Wnt effector protein T-cell factor 4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

Polycystin-1 activation of c-Jun N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

Receptor-associated constitutive protein tyrosine phosphatase activity controls the kinase function of JAK1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

PKD1 interacts with PKD2 through a probable coiled-coil domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

22 September 2017

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

25 September 2017

Perinuclear localization of the protein-tyrosine phosphatase SHP-1 and inhibition of epidermal growth factor-stimulated STAT1/3 activation in A431 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

25 September 2017

The polycystic kidney disease 1 gene product modulates Wnt signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

25 September 2017

A mouse model for polycystic kidney disease through a somatic in-frame deletion in the 5' end of Pkd1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

20 August 2018

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

20 August 2018

Dysregulation of cellular proliferation and apoptosis mediates human autosomal dominant polycystic kidney disease (ADPKD).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264829

20 August 2018

The Polycystic Kidney Disease 1 Gene Product Mediates Protein Kinase C α-dependent and c-Jun N-terminal Kinase-dependent Activation of the Transcription Factor AP-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/22178500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comprehensive molecular diagnostics in autosomal dominant polycystic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22178500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early development of polycystic kidney disease in transgenic mice expressing an activated mutant of the beta-catenin gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/22178500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polycystic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22178500

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.DEVCEL.2011.10.028

1 reference

Europe PubMed Central

PMC publication ID

22 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

22 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

22 September 2017

ResearchGate publication ID

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