(Q40607849)

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Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action

scientific article published on 12 December 2003

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scholarly article

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Europe PubMed Central

PubMed publication ID

22 September 2017

Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action (English)

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

1 reference

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Trevor M Penning

5

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

author name string

Stephan Steckelbroeck

1

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Yi Jin

2

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Sridhar Gopishetty

3

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Busola Oyesanmi

4

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

language of work or name

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publication date

12 December 2003

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Europe PubMed Central

PubMed publication ID

22 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

22 September 2017

279

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Europe PubMed Central

PubMed publication ID

22 September 2017

11

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

10784-10795

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Growth hormone-releasing factor expression is discordantly regulated in the hypothalamus and testis of streptozotocin-diabetic rats

1 reference

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21 January 2018

Molecular endocrinology of hydroxysteroid dehydrogenases

1 reference

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21 January 2018

Formation of 5α-Androstane-3α,17β-diol by Normal and Hypertrophic Human Prostate

1 reference

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21 January 2018

Steroid 5alpha-reductases and 3alpha-hydroxysteroid dehydrogenases: key enzymes in androgen metabolism

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21 January 2018

In vivo metabolism of 3H-dihydrotestosterone and 3H-androstanediol in adult male rats

1 reference

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21 January 2018

Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin

1 reference

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21 January 2018

Binding and metabolism of 5alpha-androstane-3alpha, 17 beta-diol and of 5alpha-androstane-3beta, 17 beta-diol in the prostate, seminal vesicles and plasma of male rats: studies in vivo and in vitro

1 reference

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21 January 2018

Metabolism in vitro of dihydrotestosterone, 5alpha-androstane 3alpha, 17beta-diol and its 3beta-epimer, three metabolites of testosterone, by three of its target tissues, the anterior pituitary, the medial basal hypothalamus and the seminiferous tub

1 reference

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21 January 2018

Precursors for 6beta- and 7alpha-hydroxylations of 5alpha-androstane-3beta, 17beta-diol by human normal and hyperplastic prostates

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21 January 2018

Studies on testosterone metabolism. IV. Urinary 5-alpha- and beta-androstanediols and testosterone glucuronide from testosterone and dehydrolsoandrosterone sulfate in normal people and hirsute women

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21 January 2018

Affinity labeling of human placental 3.beta.-hydroxy-.DELTA.5-steroid dehydrogenase and steroid .DELTA.-isomerase: evidence for bifunctional catalysis by a different conformation of the same protein for each enzyme activity

1 reference

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21 January 2018

Human 3 beta-hydroxysteroid dehydrogenase/delta 5----4isomerase from placenta: expression in nonsteroidogenic cells of a protein that catalyzes the dehydrogenation/isomerization of C21 and C19 steroids

1 reference

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21 January 2018

Structure and expression of a new complementary DNA encoding the almost exclusive 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human adrenals and gonads

1 reference

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21 January 2018

Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue

1 reference

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21 January 2018

cDNA cloning and characterization of a new human microsomal NAD+-dependent dehydrogenase that oxidizes all-trans-retinol and 3alpha-hydroxysteroids

1 reference

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21 January 2018

Expression cloning and characterization of oxidative 17beta- and 3alpha-hydroxysteroid dehydrogenases from rat and human prostate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313308200

21 January 2018

Further characterization of human microsomal 3alpha-hydroxysteroid dehydrogenase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313308200

21 January 2018

Characterization of a novel type of human microsomal 3alpha -hydroxysteroid dehydrogenase: unique tissue distribution and catalytic properties

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313308200

21 January 2018

Function of human brain short chain L-3-hydroxyacyl coenzyme A dehydrogenase in androgen metabolism.

1 reference

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21 January 2018

Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313308200

21 January 2018

Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution

1 reference

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21 January 2018

Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids

1 reference

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21 January 2018

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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21 January 2018

Inhibition of a major NAD(P)-linked oxidoreductase from rat liver cytosol by steroidal and nonsteroidal anti-inflammatory agents and by prostaglandins

1 reference

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21 January 2018

Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells.

1 reference

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21 January 2018

Molecular characterization of a first human 3(alpha-->beta)-hydroxysteroid epimerase

1 reference

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21 January 2018

Expression and Characterization of Recombinant Type 2 3 -Hydroxysteroid Dehydrogenase (HSD) from Human Prostate: Demonstration of Bifunctional 3 /17 -HSD Activity and Cellular Distribution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313308200

21 January 2018

Selective reduction of AKR1C2 in prostate cancer and its role in DHT metabolism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313308200

21 January 2018

Identification of amino acid residues responsible for differences in substrate specificity and inhibitor sensitivity between two human liver dihydrodiol dehydrogenase isoenzymes by site-directed mutagenesis

1 reference

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21 January 2018

A role for estrogen receptor beta in the regulation of growth of the ventral prostate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313308200

21 January 2018

An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313308200

21 January 2018

Characterization of a human 20alpha-hydroxysteroid dehydrogenase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313308200

21 January 2018

The induction of prostatic hypertrophy in the dog with androstanediol

1 reference

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21 January 2018

Prostate formation in a marsupial is mediated by the testicular androgen 5 alpha-androstane-3 alpha,17 beta-diol

1 reference

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21 January 2018

Characteristics of a highly labile human type 5 17beta-hydroxysteroid dehydrogenase

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21 January 2018

Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives

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21 January 2018

5β-Pregnan-3β-ol-20-one, a specific antagonist at the neurosteroid site of the GABAA receptor-complex

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21 January 2018

The inhibitory effects of allopregnanolone and pregnanolone on the population spike, evoked in the rat hippocampal CA1 stratum pyramidale in vitro, can be blocked selectively by epiallopregnanolone

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21 January 2018

Expression of the 17beta-hydroxysteroid dehydrogenase type 5 mRNA in the human brain

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21 January 2018

Kinetics of allopregnanolone formation catalyzed by human 3 alpha-hydroxysteroid dehydrogenase type III (AKR1C2).

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21 January 2018

Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines

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21 January 2018

Allopregnanolone serum levels and expression of 5α-reductase and 3α-hydroxysteroid dehydrogenase isoforms in hippocampal and temporal cortex of patients with epilepsy

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21 January 2018

Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone

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21 January 2018

Identifiers

10.1074/JBC.M313308200

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

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