(Q40536954)

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Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components

scientific article published on 7 July 2004

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scholarly article

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Europe PubMed Central

PubMed publication ID

21 September 2017

Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

6

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Paul Greengard

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

author name string

Hong Wang

1

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Wen-Jie Luo

2

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Yun-Wu Zhang

3

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Yue-Ming Li

4

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Gopal Thinakaran

5

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Huaxi Xu

7

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Europe PubMed Central

PubMed publication ID

21 September 2017

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publication date

7 July 2004

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Europe PubMed Central

PubMed publication ID

21 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

21 September 2017

279

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

39

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

40560-40566

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Alzheimer's disease: genotypes, phenotypes, and treatments

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Molecular genetics of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Presenilin and gamma-secretase: structure meets function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Metabolism of presenilins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Identity and function of γ‐secretase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

The role of presenilin cofactors in the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Reconstitution of gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Nicastrin binds to membrane-tethered Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Localization of presenilin-nicastrin complexes and gamma-secretase activity to the trans-Golgi network

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Expression of beta-amyloid precursor protein-CD3gamma chimeras to demonstrate the selective generation of amyloid beta(1-40) and amyloid beta(1-42) peptides within secretory and endocytic compartments

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Alzheimer's Aβ(1–42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Inhibition of Receptor-mediated Endocytosis Demonstrates Generation of Amyloid β-Protein at the Cell Surface

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Function and dysfunction of the presenilins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Identification of the role of presenilins beyond Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Effects of PS1 deficiency on membrane protein trafficking in neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

The mechanism of gamma-secretase: multiple inhibitor binding sites for transition state analogs and small molecule inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Cellular and molecular basis of beta-amyloid precursor protein metabolism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Metabolism of Alzheimer beta-amyloid precursor protein: regulation by protein kinase A in intact cells and in a cell-free system

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Regulated formation of Golgi secretory vesicles containing Alzheimer beta-amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404345200

21 January 2018

Subcellular distribution and turnover of presenilins in transfected cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M404345200

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M404345200

Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M404345200

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M404345200

Identifiers

10.1074/JBC.M404345200

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

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