(Q40520544)

21 September 2017

title

The NS5A protein of hepatitis C virus is a zinc metalloprotein (English)

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21 September 2017

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Alexander E. Gorbalenya

object named as

Alexander E Gorbalenya

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Charles M Rice

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21 September 2017

author name string

Timothy L Tellinghuisen

series ordinal

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21 September 2017

Joseph Marcotrigiano

series ordinal

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21 September 2017

language of work or name

English

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publication date

31 August 2004

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Journal of Biological Chemistry

21 September 2017

published in

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21 September 2017

volume

279

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21 September 2017

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21 September 2017

page(s)

48576-48587

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Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication

21 September 2017

cites work

1 reference

24 May 2022

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Interferon resistance of hepatitis C virus genotype 1b: relationship to nonstructural 5A gene quasispecies mutations

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Hepatitis C virus NS5A protein is phosphorylated by casein kinase II.

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https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Position-based sequence weights

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Hepatitis C virus NS5A colocalizes with the core protein on lipid droplets and interacts with apolipoproteins

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Interaction of hepatitis C virus NS5A with La protein revealed by T7 phage display

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Mutations in Hepatitis C Virus RNAs Conferring Cell Culture Adaptation

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

A workbench for multiple alignment construction and analysis

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Analysis of compositionally biased regions in sequence databases

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Structural biology of hepatitis C virus

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Identification of the major phosphorylation site of the hepatitis C virus H strain NS5A protein as serine 2321

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Evaluation and improvement of multiple sequence methods for protein secondary structure prediction.

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Amphipathic Helix-Dependent Localization of NS5A Mediates Hepatitis C Virus RNA Replication

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Efficient initiation of HCV RNA replication in cell culture

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

A second hepatitis C virus-encoded proteinase

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Analysis of zinc binding sites in protein crystal structures

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Identification of the Hepatitis C Virus RNA Replication Complex in Huh-7 Cells Harboring Subgenomic Replicons

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https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Evidence for a new hepatitis C virus antigen encoded in an overlapping reading frame

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Synthesis of a novel hepatitis C virus protein by ribosomal frameshift

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Repression of the PKR protein kinase by the hepatitis C virus NS5A protein: a potential mechanism of interferon resistance

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Identification and characterization of amphiphysin II as a novel cellular interaction partner of the hepatitis C virus NS5A protein

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Ser(2194) is a highly conserved major phosphorylation site of the hepatitis C virus nonstructural protein NS5A.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Hepatitis C virus NS5A as a potential viral Bcl-2 homologue interacts with Bax and inhibits apoptosis in hepatocellular carcinoma

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Molecular mechanisms of interferon resistance mediated by viral-directed inhibition of PKR, the interferon-induced protein kinase

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Viral and Cellular Determinants of Hepatitis C Virus RNA Replication in Cell Culture

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Modulation of interferon expression by hepatitis C virus NS5A protein and human homeodomain protein PTX1

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Subversion of Cell Signaling Pathways by Hepatitis C Virus Nonstructural 5A Protein via Interaction with Grb2 and P85 Phosphatidylinositol 3-Kinase

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Production of two phosphoproteins from the NS5A region of the hepatitis C viral genome.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: properties of the NS5A-associated kinase

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Quick-change pathogens gain an evolutionary edge

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Hepatitis C virus (HCV) NS5A protein: role in HCV replication and resistance to interferon-alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Insertion of green fluorescent protein into nonstructural protein 5A allows direct visualization of functional hepatitis C virus replication complexes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3)

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Detecting subtle sequence signals: a Gibbs sampling strategy for multiple alignment

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

The Hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Nonstructural protein 5A of hepatitis C virus inhibits the function of karyopherin beta3

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

How hepatitis C virus counteracts the interferon response: the jury is still out on NS5A.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

The NS3 proteinase domain of hepatitis C virus is a zinc-containing enzyme

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Modulation of cell growth by the hepatitis C virus nonstructural protein NS5A.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

A Human RNA Viral Cysteine Proteinase That Depends upon a Unique Zn2+-binding Finger Connecting the Two Domains of a Papain-like Fold

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Interaction between hepatitis C virus proteins and host cell factors

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

An amino-terminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5A

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Purification and characterization of hepatitis C virus non-structural protein 5A expressed in Escherichia coli

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

The galvanization of biology: a growing appreciation for the roles of zinc

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407787200

Identifiers

DOI

10.1074/JBC.M407787200

1 reference

21 September 2017

1 reference