(Q40488705)

21 September 2017

title

Phosphoinositide 3-kinase/Akt involvement in arsenic trioxide resistance of human leukemia cells (English)

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21 September 2017

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Pier Luigi Tazzari

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21 September 2017

Giovanna Tabellini

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21 September 2017

Alessandra Cappellini

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21 September 2017

Federica Falà

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21 September 2017

Anna Maria Billi

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21 September 2017

Lucia Manzoli

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21 September 2017

Lucio Cocco

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21 September 2017

Alberto M Martelli

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21 September 2017

publication date

1 February 2005

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Journal of Cellular Physiology

21 September 2017

published in

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21 September 2017

volume

202

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21 September 2017

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21 September 2017

page(s)

623-634

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Arsenic trioxide: acute promyelocytic leukemia and beyond

21 September 2017

cites work

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Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells.

21 January 2018

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Constitutive NF-κB DNA-binding activity in AML is frequently mediated by a Ras/PI3-K/PKB-dependent pathway

21 January 2018

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Constitutively active Akt1 protects HL60 leukemia cells from TRAIL-induced apoptosis through a mechanism involving NF-kappaB activation and cFLIP(L) up-regulation

21 January 2018

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Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia

21 January 2018

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The phosphoinositide 3-kinase/Akt pathway regulates cell cycle progression of HL60 human leukemia cells through cytoplasmic relocalization of the cyclin-dependent kinase inhibitor p27(Kip1) and control of cyclin D1 expression

21 January 2018

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Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.

21 January 2018

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Initiator caspases in apoptosis signaling pathways

21 January 2018

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IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

21 January 2018

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Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7.

21 January 2018

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Ascorbic acid enhances arsenic trioxide-induced cytotoxicity in multiple myeloma cells

21 January 2018

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The biochemistry of apoptosis

21 January 2018

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XIAP-mediated caspase inhibition in Hodgkin's lymphoma-derived B cells

21 January 2018

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Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571.

21 January 2018

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NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling

21 January 2018

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Arsenic trioxide-induced apoptosis in myeloma cells: p53-dependent G1 or G2/M cell cycle arrest, activation of caspase-8 or caspase-9, and synergy with APO2/TRAIL.

21 January 2018

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Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia

21 January 2018

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A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells

21 January 2018

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Inhibition of NF-kappaB essentially contributes to arsenic-induced apoptosis.

21 January 2018

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Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable

21 January 2018

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Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications

21 January 2018

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The protein kinase B/Akt signalling pathway in human malignancy

21 January 2018

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The phosphoinositide 3-kinase/Akt pathway is activated by daunorubicin in human acute myeloid leukemia cell lines.

21 January 2018

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Co-treatment with As2O3 enhances selective cytotoxic effects of STI-571 against Brc-Abl-positive acute leukemia cells

21 January 2018

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Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

21 January 2018

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Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cdelta.

21 January 2018

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Dual effects of arsenic trioxide (As2O3) on non-acute promyelocytic leukaemia myeloid cell lines: induction of apoptosis and inhibition of proliferation.

21 January 2018

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PTEN: from pathology to biology

21 January 2018

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P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) are induced by arsenic trioxide (As(2)O(3)), but are not the main mechanism of As(2)O(3)-resistance in acute promyelocytic leukemia cells

21 January 2018

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Flow cytometric detection of total and serine 473 phosphorylated Akt.

21 January 2018

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NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

21 January 2018

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Survival of acute myeloid leukemia cells requires PI3 kinase activation

21 January 2018

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The inherent cellular level of reactive oxygen species: one of the mechanisms determining apoptotic susceptibility of leukemic cells to arsenic trioxide

21 January 2018

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Studies of apoptosis of malignant lymphoma cells induced by arsenic trioxide

21 January 2018

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The induction of apoptosis and cell cycle arrest by arsenic trioxide in lymphoid neoplasms

21 January 2018

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PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCP.20153

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21 September 2017

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