(Q40471569)

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The zebrafish Kupffer's vesicle as a model system for the molecular mechanisms by which the lack of Polycystin-2 leads to stimulation of CFTR.

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Europe PubMed Central

PMC publication ID

20 September 2017

The zebrafish Kupffer's vesicle as a model system for the molecular mechanisms by which the lack of Polycystin-2 leads to stimulation of CFTR. (English)

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

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CF transmembrane conductance regulator

1 reference

GOA release 2020-03-11

Polycystic kidney disease 2

1 reference

GOA release 2020-03-11

2

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object named as

Pedro Sampaio

3

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Mónica Roxo-Rosa

object named as

Mónica Roxo-Rosa

1

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author name string

Susana Santos Lopes

4

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Europe PubMed Central

PMC publication ID

20 September 2017

publication date

2 October 2015

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Europe PubMed Central

PMC publication ID

20 September 2017

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

4

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

11

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

1356-1366

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

copyright license

Creative Commons Attribution 3.0 Unported

2 September 2020

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April 2022 Public Data File from Crossref

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describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4728361/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Intraciliary calcium oscillations initiate vertebrate left-right asymmetry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

N-glycosylation determines the abundance of the transient receptor potential channel TRPP2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Phosphodiesterase 1A modulates cystogenesis in zebrafish

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Modulation of the secretory pathway rescues zebrafish polycystic kidney disease pathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Strategies targeting cAMP signaling in the treatment of polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Cilioplasm is a cellular compartment for calcium signaling in response to mechanical and chemical stimuli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Steviol reduces MDCK Cyst formation and growth by inhibiting CFTR channel activity and promoting proteasome-mediated CFTR degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Cftr controls lumen expansion and function of Kupffer's vesicle in zebrafish

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Type of PKD1 mutation influences renal outcome in ADPKD.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Calmodulin-sensitive adenylyl cyclases mediate AVP-dependent cAMP production and Cl- secretion by human autosomal dominant polycystic kidney cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Tolvaptan inhibits ERK-dependent cell proliferation, Cl−secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Cyclic AMP-mediated cyst expansion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Pioglitazone Attenuates Cystic Burden in the PCK Rodent Model of Polycystic Kidney Disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Cse1l is a negative regulator of CFTR-dependent fluid secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

The physiological significance of the cardiotonic steroid/ouabain-binding site of the Na,K-ATPase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Advances in the pathogenesis and treatment of polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

The subcellular localization of TRPP2 modulates its function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Small-molecule CFTR inhibitors slow cyst growth in polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Human ADPKD primary cyst epithelial cells with a novel, single codon deletion in the PKD1 gene exhibit defective ciliary polycystin localization and loss of flow-induced Ca2+ signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Polycystin-2 immunolocalization and function in zebrafish

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

A regulatory role of polycystin-1 on cystic fibrosis transmembrane conductance regulator plasma membrane expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

The relationship between cell proliferation, Cl- secretion, and renal cyst growth: a study using CFTR inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Identification and characterization of polycystin-2, the PKD2 gene product

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Stages of embryonic development of the zebrafish

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

22 September 2017

Altered store operated calcium entry increases cyclic 3′,5′-adenosine monophosphate production and extracellular signal-regulated kinases 1 and 2 phosphorylation in polycystin-2-defective cholangiocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

25 September 2017

Bending the MDCK cell primary cilium increases intracellular calcium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

25 September 2017

Organized chaos in Kupffer's vesicle: how a heterogeneous structure achieves consistent left-right patterning

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

15 June 2018

The notochord breaks bilateral symmetry by controlling cell shapes in the zebrafish laterality organ.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

20 August 2018

Left-right organizer flow dynamics: how much cilia activity reliably yields laterality?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

20 August 2018

Steviol retards renal cyst growth through reduction of CFTR expression and inhibition of epithelial cell proliferation in a mouse model of polycystic kidney disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

20 August 2018

Post-translational modifications of CFTR: insight into protein trafficking and cystic fibrosis disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

20 August 2018

Pkd1l1 complexes with Pkd2 on motile cilia and functions to establish the left-right axis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

20 August 2018

Zebrafish curly up encodes a Pkd2 ortholog that restricts left-side-specific expression of southpaw

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

20 August 2018

Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

20 August 2018

Visualizing morphogenesis in transgenic zebrafish embryos using BODIPY TR methyl ester dye as a vital counterstain for GFP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

20 August 2018

A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

20 August 2018

Impact of the cystic fibrosis mutation F508del-CFTR on renal cyst formation and growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4728361

2 December 2018

Cyst formation and growth in autosomal dominant polycystic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26432887

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium restores a normal proliferation phenotype in human polycystic kidney disease epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/26432887

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autosomal dominant polycystic kidney disease coexisting with cystic fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26432887

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for CFTR in human autosomal dominant polycystic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26432887

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1242/BIO.014076

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

ResearchGate publication ID

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