(Q40305093)

19 September 2017

title

The interaction between cytoplasmic prion protein and the hydrophobic lipid core of membrane correlates with neurotoxicity (English)

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19 September 2017

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1 reference

1 reference

Xinhe Wang

1 reference

19 September 2017

Fei Wang

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19 September 2017

Linnea Arterburn

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19 September 2017

Robert Wollmann

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19 September 2017

Jiyan Ma

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19 September 2017

language of work or name

English

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publication date

14 March 2006

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Journal of Biological Chemistry

19 September 2017

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inferred from page(s)

published in

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19 September 2017

volume

281

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19 September 2017

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19 September 2017

page(s)

13559-13565

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https://api.crossref.org/works/10.1074%2FJBC.M512306200

19 September 2017

1 reference

Mice devoid of PrP are resistant to scrapie

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Synthetic mammalian prions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

In vitro generation of infectious scrapie prions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Cell-free formation of protease-resistant prion protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Visualization of prion infection in transgenic mice expressing green fluorescent protein-tagged prion protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Cytosolic prion protein is not toxic and protects against Bax-mediated cell death in human primary neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Wild-type PrP and a mutant associated with prion disease are subject to retrograde transport and proteasome degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Calpain and other cytosolic proteases can contribute to the degradation of retro-translocated prion protein in the cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Protection from cytosolic prion protein toxicity by modulation of protein translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Post-translational import of the prion protein into the endoplasmic reticulum interferes with cell viability: a critical role for the putative transmembrane domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

De novo generation of a PrPSc-like conformation in living cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Cytosolic prion protein (PrP) is not toxic in N2a cells and primary neurons expressing pathogenic PrP mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Characterization of stanniocalcin 2, a novel target of the mammalian unfolded protein response with cytoprotective properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Identification and characterization of epsilon-sarcoglycans in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Coexistence of multiple PrPSc types in individuals with Creutzfeldt-Jakob disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Coincident scrapie infection and nephritis lead to urinary prion excretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Involvement of phospholipase A2 in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Biochemical aspects of neurodegeneration in human brain: involvement of neural membrane phospholipids and phospholipases A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Phospholipase A2 inhibitors or platelet-activating factor antagonists prevent prion replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Role of glycosylphosphatidylinositols in the activation of phospholipase A2 and the neurotoxicity of prions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Synapsin I interacts with c-Src and stimulates its tyrosine kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

A vector for expressing foreign genes in the brains and hearts of transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Effect of glycosylphosphatidylinositol anchor-dependent and -independent prion protein association with model raft membranes on conversion to the protease-resistant isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Structural changes of the prion protein in lipid membranes leading to aggregation and fibrillization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Binding of prion protein to lipid membranes and implications for prion conversion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Binding of prion proteins to lipid membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Calcium pumps of plasma membrane and cell interior

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Mitochondria in Ca2+ signaling and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Mitochondria, calcium and pro-apoptotic proteins as mediators in cell death signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Cell biology. Apoptosis--the calcium connection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Bcl-2 decreases the free Ca2+ concentration within the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Reduced loading of intracellular Ca(2+) stores and downregulation of capacitative Ca(2+) influx in Bcl-2-overexpressing cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Identification of cryptic nuclear localization signals in the prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

Scrapie-like prion protein is translocated to the nuclei of infected cells independently of proteasome inhibition and interacts with chromatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512306200

21 January 2018

Identifiers

DOI

10.1074/JBC.M512306200

1 reference

19 September 2017

1 reference