(Q40299700)

19 September 2017

title

Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization (English)

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19 September 2017

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Jeffery W Kelly

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19 September 2017

Daryl A Bosco

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19 September 2017

Douglas M Fowler

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19 September 2017

Qinghai Zhang

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19 September 2017

Jorge Nieva

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19 September 2017

Evan T Powers

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19 September 2017

Paul Wentworth

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19 September 2017

Richard A Lerner

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19 September 2017

publication date

26 March 2006

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19 September 2017

published in

Nature Chemical Biology

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19 September 2017

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19 September 2017

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19 September 2017

page(s)

249-253

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alpha-Synuclein locus triplication causes Parkinson's disease

19 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO782

7 January 2021

The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.

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https://api.crossref.org/works/10.1038%2FNCHEMBIO782

7 January 2021

Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein

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https://api.crossref.org/works/10.1038%2FNCHEMBIO782

7 January 2021

Tissue transglutaminase is not involved in the aggregate formation of stably expressed alpha-synuclein in SH-SY5Y human neuroblastoma cells

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https://api.crossref.org/works/10.1038%2FNCHEMBIO782

7 January 2021

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

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https://api.crossref.org/works/10.1038%2FNCHEMBIO782

7 January 2021

Lipid rafts mediate the synaptic localization of alpha-synuclein.

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https://api.crossref.org/works/10.1038%2FNCHEMBIO782

7 January 2021

Evidence for Ozone Formation in Human Atherosclerotic Arteries

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https://api.crossref.org/works/10.1038%2FNCHEMBIO782

7 January 2021

Metabolite-initiated protein misfolding may trigger Alzheimer's disease

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https://api.crossref.org/works/10.1038%2FNCHEMBIO782

7 January 2021

Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation

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https://api.crossref.org/works/10.1038%2FNCHEMBIO782

7 January 2021

Dementia with Lewy bodies: a review

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https://api.crossref.org/works/10.1038%2FNCHEMBIO782

7 January 2021

Human alpha-synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine.

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https://api.crossref.org/works/10.1038%2FNCHEMBIO782

7 January 2021

Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult

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https://api.crossref.org/works/10.1038%2FNCHEMBIO782

7 January 2021

Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

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https://api.crossref.org/works/10.1038%2FNCHEMBIO782

7 January 2021

Rapid Anionic Micelle-mediated α-Synuclein Fibrillization in Vitro

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https://api.crossref.org/works/10.1038%2FNCHEMBIO782

7 January 2021

alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO782

7 January 2021

Identifiers

DOI

10.1038/NCHEMBIO782

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Dimensions Publication ID

19 September 2017

1052189675

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