(Q40033262)

16 September 2017

title

Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process (English)

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16 September 2017

main subject

protein ubiquitination

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Orane Visvikis

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Patrick Lorès

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Laurent Boyer

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Emmanuel Lemichez

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Pierre Chardin

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16 September 2017

Gérard Gacon

series ordinal

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16 September 2017

language of work or name

English

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publication date

17 December 2007

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16 September 2017

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16 September 2017

volume

275

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16 September 2017

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16 September 2017

page(s)

386-396

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Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking

16 September 2017

cites work

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Monogenic causes of X-linked mental retardation.

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Bacterial virulence factors targeting Rho GTPases: parasitism or symbiosis?

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Rho GTPases as targets of bacterial protein toxins

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Genomic analysis of metastasis reveals an essential role for RhoC

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Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors

21 January 2018

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Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b

21 January 2018

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Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

21 January 2018

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Activation of tumor-specific splice variant Rac1b by dishevelled promotes canonical Wnt signaling and decreased adhesion of colorectal cancer cells

21 January 2018

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CNF1 exploits the ubiquitin-proteasome machinery to restrict Rho GTPase activation for bacterial host cell invasion

21 January 2018

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Proteasomal degradation of cytotoxic necrotizing factor 1-activated rac.

21 January 2018

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21 January 2018

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Polyubiquitin chains: polymeric protein signals

21 January 2018

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Ubiquitylation and cell signaling

21 January 2018

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Regulation of cell polarity and protrusion formation by targeting RhoA for degradation

21 January 2018

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Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

21 January 2018

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Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility

21 January 2018

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CNF1-induced ubiquitylation and proteasome destruction of activated RhoA is impaired in Smurf1-/- cells

21 January 2018

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Proteasome-mediated degradation of Rac1-GTP during epithelial cell scattering

21 January 2018

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Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages.

21 January 2018

1 reference

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Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase

21 January 2018

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21 January 2018

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Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation

21 January 2018

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Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases

21 January 2018

1 reference

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Structure of the TPR domain of p67phox in complex with Rac.GTP

21 January 2018

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Structure of the ExoS GTPase activating domain

21 January 2018

1 reference

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Modulation of host signaling by a bacterial mimic: structure of the Salmonella effector SptP bound to Rac1

21 January 2018

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The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI

21 January 2018

1 reference

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Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

21 January 2018

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Ubiquitin-mediated proteasomal degradation of Rho proteins by the CNF1 toxin

21 January 2018

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Isotype-specific degradation of Rac activated by the cytotoxic necrotizing factor 1.

21 January 2018

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The ubiquitin-proteasome system regulates membrane fusion of yeast vacuoles

21 January 2018

1 reference

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Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.06209.X

Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.06209.X

A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.06209.X

POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2007.06209.X

10.1111/J.1742-4658.2007.06209.X

21 January 2018

Identifiers

DOI

1 reference

16 September 2017

1 reference