(Q40022761)

English

DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis

scientific article published on July 1997

In more languages

default for all languages

No label defined

No description defined

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis (English)

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

apoptotic process

1 reference

based on heuristic

inferred from title

5

object named as

P D Aplan

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

author name string

M Stanulla

1

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

J Wang

2

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

D S Chervinsky

3

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

S Thandla

4

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

language of work or name

0 references

publication date

1 July 1997

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

Molecular and Cellular Biology

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

17

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

7

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

4070-4079

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

Mapping of genomic DNA loop organization in a 500-kilobase region of the Drosophila X chromosome by the topoisomerase II-mediated DNA loop excision protocol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

22 September 2017

Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

22 September 2017

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

22 September 2017

Apoptosis in cancer therapy: crossing the threshold

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

22 September 2017

Fine mapping of 28S rRNA sites specifically cleaved in cells undergoing apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

22 September 2017

Cell death: the significance of apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

22 September 2017

Organization of the higher-order chromatin loop: specific DNA attachment sites on nuclear scaffold

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

22 September 2017

Chromosomal loop anchorage sites appear to be evolutionarily conserved

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

22 September 2017

Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

22 September 2017

Topoisomerase II is a structural component of mitotic chromosome scaffolds.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

22 September 2017

A consensus sequence for cleavage by vertebrate DNA topoisomerase II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

22 September 2017

Preferential, cooperative binding of DNA topoisomerase II to scaffold-associated regions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

22 September 2017

Dysfunction of chromosomal loop attachment sites: illegitimate recombination linked to matrix association regions and topoisomerase II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

22 September 2017

Disruption of the human SCL locus by "illegitimate" V-(D)-J recombinase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

22 September 2017

The SCL gene is formed from a transcriptionally complex locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

22 September 2017

Chromosomal translocations in lymphoid neoplasia: a reappraisal of the recombinase model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

22 September 2017

Transgenic models of tumor development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

22 September 2017

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

22 September 2017

Precise localization of the alpha-globin gene cluster within one of the 20- to 300-kilobase DNA fragments released by cleavage of chicken chromosomal DNA at topoisomerase II sites in vivo: evidence that the fragments are DNA loops or domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

22 September 2017

Mechanisms of resistance to drugs that inhibit DNA topoisomerases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

22 September 2017

Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

22 September 2017

Cloning of cDNAs of the MLL gene that detect DNA rearrangements and altered RNA transcripts in human leukemic cells with 11q23 translocations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

22 September 2017

Apoptosis induced by anticancer drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

22 September 2017

In vivo topoisomerase II cleavage of the Drosophila histone and satellite III repeats: DNA sequence and structural characteristics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

22 September 2017

The secondary leukemias: challenges and research directions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

25 September 2017

11q23 rearrangements in acute leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

25 September 2017

Use of transgenic mice to study myc family gene function in normal mammalian development and in cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

25 September 2017

Topoisomerase II inhibitors induce DNA double-strand breaks at a specific site within the AML1 locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

25 September 2017

The size of chromatin loops in HeLa cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

25 September 2017

Investigation of the mechanism of higher order chromatin fragmentation observed in drug-induced apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

25 September 2017

Large-scale fragmentation of mammalian DNA in the course of apoptosis proceeds via excision of chromosomal DNA loops and their oligomers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

25 September 2017

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

25 September 2017

Altered catalytic activity of and DNA cleavage by DNA topoisomerase II from human leukemic cells selected for resistance to VM-26.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

25 September 2017

Etoposide-induced cytotoxicity in two human T-cell leukemic lines: delayed loss of membrane permeability rather than DNA fragmentation as an indicator of programmed cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

17 June 2018

Cancer: the rise of the genetic paradigm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

17 June 2018

Identification of a nuclear protein matrix.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

17 June 2018

Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

17 June 2018

Cohabitation of scaffold binding regions with upstream/enhancer elements of three developmentally regulated genes of D. melanogaster.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

17 June 2018

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

17 June 2018

Decreased nuclear matrix DNA topoisomerase II in human leukemia cells resistant to VM-26 and m-AMSA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

17 June 2018

Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

20 August 2018

ALL-1 tandem duplication in acute myeloid leukemia with a normal karyotype involves homologous recombination between Alu elements.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

20 August 2018

Chromosomal translocations in human cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

20 August 2018

ALL-1 gene rearrangements in DNA topoisomerase II inhibitor-related leukemia in children.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

20 August 2018

Inhibition of etoposide (VP-16)-induced DNA recombination and mutant frequency by Bcl-2 protein overexpression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=232260

20 August 2018

Secondary acute myeloid leukemia in children with acute lymphoblastic leukemia treated with etoposide

1 reference

https://pubmed.ncbi.nlm.nih.gov/9199342

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myelodysplastic syndrome with t(9;11)(p22;q23) after treatment for B-cell acute lymphoblastic leukemia without epipodophyllotoxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/9199342

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Balanced translocations involving chromosome bands 11q23 and 21q22 are highly characteristic of myelodysplasia and leukemia following therapy with cytostatic agents targeting at DNA-topoisomerase II

1 reference

https://pubmed.ncbi.nlm.nih.gov/9199342

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Death-defying acts: a meeting review on apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9199342

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Platinum agents and secondary myeloid leukaemia: two cases treated only with platinum-based drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/9199342

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of DNA fragmentation in apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9199342

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-random cleavage of SV40 DNA in the compact minichromosome and free in solution by micrococcal nuclease

1 reference

https://pubmed.ncbi.nlm.nih.gov/9199342

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Teniposide-resistant CEM cells, which express mutant DNA topoisomerase II alpha, when treated with non-complex-stabilizing inhibitors of the enzyme, display no cross-resistance and reveal aberrant functions of the mutant enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/9199342

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The chemotherapeutic drug melphalan induces breakage of chromosomes regions rearranged in secondary leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/9199342

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: correlation with scaffold attachment regions and topoisomerase II consensus binding sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/9199342

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA-topoisomerase II

1 reference

https://pubmed.ncbi.nlm.nih.gov/9199342

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chromosome aberrations induced by etoposide (VP-16) are not random

1 reference

https://pubmed.ncbi.nlm.nih.gov/9199342

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The molecular basis of leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/9199342

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different genetic pathways in leukemogenesis for patients presenting with therapy-related myelodysplasia and therapy-related acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/9199342

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance of mitochondrial DNA to degradation characterizes the apoptotic but not the necrotic mode of human leukemia cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/9199342

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute nonlymphocytic leukemia following etoposide and cisplatin combination chemotherapy for advanced non-small-cell carcinoma of the lung

1 reference

https://pubmed.ncbi.nlm.nih.gov/9199342

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.17.7.4070

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q40022761&oldid=2167866283"