(Q53499832)

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Developing postmitotic mammalian neurons in vivo lacking Apaf-1 undergo programmed cell death by a caspase-independent, nonapoptotic pathway involving autophagy.

scientific article published in February 2008

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2 January 2020

Developing postmitotic mammalian neurons in vivo lacking Apaf-1 undergo programmed cell death by a caspase-independent, nonapoptotic pathway involving autophagy (English)

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2 January 2020

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2 January 2020

Douglas W Ethell

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2 January 2020

4

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2 January 2020

7

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2 January 2020

Masaaki Komatsu

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2 January 2020

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Ronald W Oppenheim

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2 January 2020

David Prevette

6

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2 January 2020

Yasuo Uchiyama

8

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2 January 2020

Sharon Vinsant

9

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2 January 2020

Changlian Zhu

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2 January 2020

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1 February 2008

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2 January 2020

Journal of Neuroscience

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2 January 2020

28

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2 January 2020

6

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2 January 2020

1490-1497

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2 January 2020

Active suppression of interneuron programs within developing motor neurons revealed by analysis of homeodomain factor HB9.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy is activated by apoptotic signalling in sympathetic neurons: an alternative mechanism of death execution

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

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Adult Apaf-1-deficient mice exhibit male infertility

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of programmed cell death in the developing brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

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An alternative, nonapoptotic form of programmed cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-3 activation after neonatal rat cerebral hypoxia-ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Programmed cell death of developing mammalian neurons after genetic deletion of caspases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apaf-1 deficiency and neural tube closure defects are found in fog mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase activity is involved in, but is dispensable for, early motoneuron death in the chick embryo cervical spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

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Embryonic neuronal death due to neurotrophin and neurotransmitter deprivation occurs independent of Apaf-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagic cell death and its execution by lysosomal cathepsins

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The harlequin mouse mutation downregulates apoptosis-inducing factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of caspase-independent neuronal death: energy depletion and free radical generation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apaf1-dependent programmed cell death is required for inner ear morphogenesis and growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Irradiation-induced progenitor cell death in the developing brain is resistant to erythropoietin treatment and caspase inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosome inactivation rescues proneural and neural cells from neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis, autophagy, and more

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

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Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

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Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

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Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Do inducers of apoptosis trigger caspase-independent cell death?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

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Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein retention in the endoplasmic reticulum, blockade of programmed cell death and autophagy selectively occur in spinal cord motoneurons after glutamate receptor-mediated injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-independent cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

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Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy in cell death: an innocent convict?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Doctor Jekyll and Mister Hyde: autophagy can promote both cell survival and cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

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Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell death in early neural life

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy occurs upstream or parallel to the apoptosome during histolytic cell death.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of autophagy in the central nervous system causes neurodegeneration in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adaptive roles of programmed cell death during nervous system development

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy in neurodegenerative disease: friend, foe or turncoat?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy and its possible roles in nervous system diseases, damage and repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosome dependent caspase-3 activation pathway is non-redundant and necessary for apoptosis in sympathetic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An in vivo analysis of Schwann cell programmed cell death in embryonic mice: the role of axons, glial growth factor, and the pro-apoptotic gene Bax

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

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Cell death in the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

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Excitotoxic motoneuron disease in chick embryo evolves with autophagic neurodegeneration and deregulation of neuromuscular innervation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Survival and death of mature avian motoneurons in organotypic slice culture: trophic requirements for survival and different types of degeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy: paying Charon's toll

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy gene-dependent clearance of apoptotic cells during embryonic development

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathological apoptosis in the developing brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ambra1 regulates autophagy and development of the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell death during development of the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmental cell death: morphological diversity and multiple mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell death of motoneurons in the chick embryo spinal cord. I. A light and electron microscopic study of naturally occurring and induced cell loss during development

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuron death in vertebrate development: in vitro methods

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Forebrain overgrowth (fog): A new mutation in the mouse affecting neural tube development

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Muscle-specific cell ablation conditional upon Cre-mediated DNA recombination in transgenic mice leads to massive spinal and cranial motoneuron loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential requirement for caspase 9 in apoptotic pathways in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

1 reference

https://pubmed.ncbi.nlm.nih.gov/18256270

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.4575-07.2008

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18256270%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18256270%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18256270%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

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