(Q46412461)

English

Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation

scientific article published on 25 August 2008

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18725412

Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation (English)

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18725412

phosphorylation

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based on heuristic

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Eckhard Mandelkow

6

object named as

Eckhard Mandelkow

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Europe PubMed Central

PubMed publication ID

22 December 2017

Eva-Maria Mandelkow

5

object named as

Eva-Maria Mandelkow

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

author name string

Sadasivam Jeganathan

1

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18725412

Antje Hascher

2

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18725412

Subashchandrabose Chinnathambi

3

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18725412

Jacek Biernat

4

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18725412

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publication date

25 August 2008

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18725412

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18725412

283

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18725412

46

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18725412

32066-32076

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Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18725412

Global hairpin folding of tau in solution

1 reference

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21 January 2018

Molecular motors and mechanisms of directional transport in neurons

1 reference

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21 January 2018

Structural principles of tau and the paired helical filaments of Alzheimer's disease

1 reference

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21 January 2018

Going new places using an old MAP: tau, microtubules and human neurodegenerative disease.

1 reference

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21 January 2018

Tau, tangles, and Alzheimer's disease

1 reference

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21 January 2018

Tau protein function in living cells

1 reference

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21 January 2018

The primary structure and heterogeneity of tau protein from mouse brain

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Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

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21 January 2018

Neuropathological stageing of Alzheimer-related changes

1 reference

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21 January 2018

Tau phosphorylation in neuronal cell function and dysfunction

1 reference

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21 January 2018

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase

1 reference

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21 January 2018

Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau.

1 reference

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21 January 2018

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

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21 January 2018

Mammalian SAD kinases are required for neuronal polarization

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21 January 2018

Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Disease-related modifications in tau affect the interaction between Fyn and Tau.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase.

1 reference

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21 January 2018

Post-translational modifications of tau protein in Alzheimer's disease

1 reference

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21 January 2018

Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

The peptidyl prolyl cis/trans-isomerase Pin1 recognizes the phospho-Thr212-Pro213 site on Tau.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Interaction of tau protein with the dynactin complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Tau-66: evidence for a novel tau conformation in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Phosphorylation-dependent epitopes of neurofilament antibodies on tau protein and relationship with Alzheimer tau

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Folding of Alzheimer's core PHF subunit revealed by monoclonal antibody 423.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Constitutive activation of Mek1 by mutation of serine phosphorylation sites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Efficient site-specific labeling of proteins via cysteines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Fluorescence energy transfer between ligand binding sites on aspartate transcarbamylase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Probing the free-energy surface for protein folding with single-molecule fluorescence spectroscopy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Epitope mapping of mAbs AT8 and Tau5 directed against hyperphosphorylated regions of the human tau protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Modeling tau polymerization in vitro: a review and synthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Glycogen synthase kinase 3beta phosphorylates tau at both primed and unprimed sites. Differential impact on microtubule binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Tau proteins: the molecular structure and mode of binding on microtubules

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Correlations of synaptic and pathological markers with cognition of the elderly

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

The "jaws" of the tau-microtubule interaction.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M805300200

21 January 2018

Reassessing random-coil statistics in unfolded proteins

1 reference

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21 January 2018

Protein misfolding, evolution and disease

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21 January 2018

Identifiers

10.1074/JBC.M805300200

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18725412

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 December 2017

http://europepmc.org/abstract/MED/18725412

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