(Q39635066)

13 September 2017

title

Germline Brca2 heterozygosity promotes Kras(G12D) -driven carcinogenesis in a murine model of familial pancreatic cancer (English)

1 reference

13 September 2017

Germline Brca2 Heterozygosity Promotes KrasG12D -Driven Carcinogenesis in a Murine Model of Familial Pancreatic Cancer (English)

1 reference

Crossref

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

21 August 2024

1 reference

1 reference

1 reference

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21056012

21 August 2024

germline mutation

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21056012

21 August 2024

BRCA2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21056012

21 August 2024

David A Tuveson

1 reference

13 September 2017

Liam D. Cassidy

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21056012

21 August 2024

Florian A. Karreth

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21056012

21 August 2024

Michael Lim

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21056012

21 August 2024

Kenneth P. Olive

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21056012

21 August 2024

author name string

Ferdinandos Skoulidis

1 reference

13 September 2017

Venkat Pisupati

1 reference

13 September 2017

Hordur Bjarnason

1 reference

13 September 2017

Jon G. Jonasson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21056012

21 August 2024

Jorunn E. Eyfjord

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21056012

21 August 2024

Lorraine M. Barber

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21056012

21 August 2024

Susan A. Clatworthy

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21056012

21 August 2024

Susan E. Davies

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21056012

21 August 2024

David A. Tuveson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21056012

21 August 2024

Ashok R. Venkitaraman

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21056012

21 August 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21056012

21 August 2024

publication date

4 November 2010

1 reference

full work available at URL

13 September 2017

http://www.cell.com/article/S1535610810004204/pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21056012

https://api.elsevier.com/content/article/PII:S1535610810004204?httpAccept=text/xml

21 August 2024

1 reference

Crossref

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

https://api.elsevier.com/content/article/PII:S1535610810004204?httpAccept=text/plain

21 August 2024

1 reference

Crossref

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

21 August 2024

1 reference

13 September 2017

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13 September 2017

1 reference

13 September 2017

page(s)

499-509

1 reference

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

13 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Cancer risks in BRCA2 mutation carriers

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

K-ras mutation and pancreatic adenocarcinoma

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

The prevalence of BRCA2 mutations in familial pancreatic cancer

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Thymic lymphomas in mice with a truncating mutation in Brca2

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Gene-specific selection against experimental fanconi anemia gene inactivation in human cancer

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

High-throughput SNP allele-frequency determination in pooled DNA samples by kinetic PCR.

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

BRCA2 is inactivated late in the development of pancreatic intraepithelial neoplasia: evidence and implications

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Different tumor types from BRCA2 carriers show wild-type chromosome deletions on 13q12-q13

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

BRCA2 germline mutations in familial pancreatic carcinoma

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Genetics and biology of pancreatic ductal adenocarcinoma.

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Heterogenic loss of the wild-type BRCA allele in human breast tumorigenesis

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Mutation and cancer: statistical study of retinoblastoma

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

The Icelandic founder mutation BRCA2 999del5: analysis of expression

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Loss of heterozygosity analysis at theBRCAloci in tumor samples from patients with familial breast cancer

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Physiological analysis of oncogenic K-ras

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Analysis of murine Brca2 reveals conservation of protein-protein interactions but differences in nuclear localization signals

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Successful growth and characterization of mouse pancreatic ductal cells: functional properties of the Ki-RAS(G12V) oncogene

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

A single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Study of a single BRCA2 mutation with high carrier frequency in a small population

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2

21 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.CCR.2010.10.015

21 August 2024

Identifiers

1 reference

release_rfaghgx3bza3tpdhjjowhs6rey

13 September 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/rfaghgx3bza3tpdhjjowhs6rey

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference