(Q36430193)

14 August 2017

title

Protein-tyrosine phosphatases and cancer. (English)

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14 August 2017

Arne Ostman

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14 August 2017

Carina Hellberg

series ordinal

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14 August 2017

Frank D Böhmer

series ordinal

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14 August 2017

language of work or name

English

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publication date

1 April 2006

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14 August 2017

published in

Nature Reviews Cancer

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14 August 2017

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14 August 2017

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14 August 2017

page(s)

307-320

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Oncogenic kinase signalling

14 August 2017

cites work

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21 January 2018

Targeted cancer therapy

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Structural and evolutionary relationships among protein tyrosine phosphatase domains

21 January 2018

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Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatases

21 January 2018

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Protein tyrosine phosphatases in the human genome

21 January 2018

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Dual specificity protein phosphatases: therapeutic targets for cancer and Alzheimer's disease

21 January 2018

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Low molecular weight protein tyrosine phosphatases: small, but smart.

21 January 2018

1 reference

PTEN: from pathology to biology

21 January 2018

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'Zip codes' direct intracellular protein tyrosine phosphatases to the correct cellular 'address'.

21 January 2018

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Substrate specificity of the protein tyrosine phosphatases

21 January 2018

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Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases

21 January 2018

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Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1

21 January 2018

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Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase

21 January 2018

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Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B

21 January 2018

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Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B

21 January 2018

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Imaging sites of receptor dephosphorylation by PTP1B on the surface of the endoplasmic reticulum

21 January 2018

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UVA inactivates protein tyrosine phosphatases by calpain-mediated degradation

21 January 2018

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Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase

21 January 2018

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Dimerization-Induced Inhibition of Receptor Protein Tyrosine Phosphatase Function Through an Inhibitory Wedge

21 January 2018

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Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerization

21 January 2018

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Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-alpha

21 January 2018

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Crystal structure of the tandem phosphatase domains of RPTP LAR

21 January 2018

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Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45

21 January 2018

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Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo

21 January 2018

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Receptor tyrosine phosphatase R-PTP-kappa mediates homophilic binding

21 January 2018

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An extracellular ligand increases the specific activity of the receptor-like protein tyrosine phosphatase DEP-1.

21 January 2018

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Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta

21 January 2018

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Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

21 January 2018

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Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B.

21 January 2018

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The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

21 January 2018

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Integrin signalling during tumour progression

21 January 2018

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Cell adhesion and signalling by cadherins and Ig-CAMs in cancer

21 January 2018

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The regulation of cadherin-mediated adhesion by tyrosine phosphorylation/dephosphorylation of beta-catenin

21 January 2018

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Receptor protein tyrosine phosphatase micro regulates the paracellular pathway in human lung microvascular endothelia

21 January 2018

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Tyrosine phosphatases in vessel wall signaling

21 January 2018

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Phosphatases in cell-matrix adhesion and migration

21 January 2018

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Mutational analysis of the tyrosine kinome in colorectal cancers

21 January 2018

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Lung cancer: intragenic ERBB2 kinase mutations in tumours

21 January 2018

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Mutational analysis of the tyrosine phosphatome in colorectal cancers

21 January 2018

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Molecular analysis of receptor protein tyrosine phosphatase mu-mediated cell adhesion

21 January 2018

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Rat protein tyrosine phosphatase eta suppresses the neoplastic phenotype of retrovirally transformed thyroid cells through the stabilization of p27(Kip1).

21 January 2018

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Restoration of receptor-type protein tyrosine phosphatase eta function inhibits human pancreatic carcinoma cell growth in vitro and in vivo

21 January 2018

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Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers

21 January 2018

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Fine mapping of colon tumor susceptibility (Scc) genes in the mouse, different from the genes known to be somatically mutated in colon cancer

21 January 2018

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LOH of PTPRJ occurs early in colorectal cancer and is associated with chromosomal loss of 18q12-21.

21 January 2018

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The tyrosine phosphatase PTPRJ/DEP-1 genotype affects thyroid carcinogenesis

21 January 2018

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Mass spectrometry-based loss of heterozygosity analysis of single-nucleotide polymorphism loci in paraffin embedded tumors using the MassEXTEND assay: single-nucleotide polymorphism loss of heterozygosity analysis of the protein tyrosine phosphatase

21 January 2018

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Allelic association of the human homologue of the mouse modifier Ptprj with breast cancer

21 January 2018

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Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1

21 January 2018

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The protein-tyrosine phosphatase DEP-1 modulates growth factor-stimulated cell migration and cell-matrix adhesion

21 January 2018

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Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148

21 January 2018

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The C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions

21 January 2018

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The rat tyrosine phosphatase eta increases cell adhesion by activating c-Src through dephosphorylation of its inhibitory phosphotyrosine residue

21 January 2018

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The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)

21 January 2018

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Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance.

21 January 2018

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A mutant receptor tyrosine phosphatase, CD148, causes defects in vascular development

21 January 2018

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The history of cancer epigenetics

21 January 2018

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Lack of phosphotyrosine phosphatase SHP-1 expression in malignant T-cell lymphoma cells results from methylation of the SHP-1 promoter

21 January 2018

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Methylation of SHP1 gene and loss of SHP1 protein expression are frequent in systemic anaplastic large cell lymphoma

21 January 2018

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SOCS1 and SHP1 hypermethylation in multiple myeloma: implications for epigenetic activation of the Jak/STAT pathway

21 January 2018

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STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes

21 January 2018

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Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas

21 January 2018

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Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer

21 January 2018

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Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate

21 January 2018

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Shp-2 tyrosine phosphatase: signaling one cell or many

21 January 2018

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SHP-2-dependent mitogen-activated protein kinase activation regulates EGFRvIII but not wild-type epidermal growth factor receptor phosphorylation and glioblastoma cell survival

21 January 2018

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The tyrosine phosphatase Shp-2 mediates intracellular signaling initiated by Ret mutants

21 January 2018

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The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3

21 January 2018

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A role for the scaffolding adapter GAB2 in breast cancer

21 January 2018

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Critical role for Gab2 in transformation by BCR/ABL

21 January 2018

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Oncogenic mechanisms of the Helicobacter pylori CagA protein

21 January 2018

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Identification of a putative Syp substrate, the PDGF beta receptor

21 January 2018

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A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation

21 January 2018

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Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment

21 January 2018

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Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor

21 January 2018

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The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling

21 January 2018

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Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

21 January 2018

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Germ-line and somatic PTPN11 mutations in human disease

21 January 2018

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Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

21 January 2018

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Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis

21 January 2018

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Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia

21 January 2018

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Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia

21 January 2018

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Somatic PTPN11 mutations in childhood acute myeloid leukaemia

21 January 2018

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Crystal Structure of the Tyrosine Phosphatase SHP-2

21 January 2018

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Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps

21 January 2018

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Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes

21 January 2018

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Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.

21 January 2018

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Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells

21 January 2018

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Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

21 January 2018

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Functional analysis of PTPN11/SHP-2 mutants identified in Noonan syndrome and childhood leukemia

21 January 2018

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Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor

21 January 2018

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Targeted disruption of the tyrosine phosphatase PTPalpha leads to constitutive downregulation of the kinases Src and Fyn.

21 January 2018

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Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase

21 January 2018

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Protein tyrosine phosphatase epsilon increases the risk of mammary hyperplasia and mammary tumors in transgenic mice.

21 January 2018

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Tyrosine phosphatase-epsilon activates Src and supports the transformed phenotype of Neu-induced mammary tumor cells

21 January 2018

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The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells

21 January 2018

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TIMP-2 mediated inhibition of angiogenesis: an MMP-independent mechanism

21 January 2018

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Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2

21 January 2018

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Vascular endothelial-cadherin tyrosine phosphorylation in angiogenic and quiescent adult tissues

21 January 2018

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An attempt to promote neo-vascularization by employing a newly synthesized inhibitor of protein tyrosine phosphatase

21 January 2018

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Tyrosine phosphatase inhibition augments collateral blood flow in a rat model of peripheral vascular disease

21 January 2018

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Guidance of vascular and neural network formation

21 January 2018

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A role for axon guidance receptors and ligands in blood vessel development and tumor angiogenesis

21 January 2018

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Receptor protein tyrosine phosphatases in nervous system development

21 January 2018

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Functional significance of the LAR receptor protein tyrosine phosphatase family in development and diseases

21 January 2018

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Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation

21 January 2018

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Selecting protein tyrosine phosphatases as drug targets

21 January 2018

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Inhibitors of protein tyrosine phosphatases: next-generation drugs?

21 January 2018

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Protein tyrosine phosphatase 1B inhibitors for diabetes

21 January 2018

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The role of protein-tyrosine phosphatase 1B in integrin signaling

21 January 2018

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Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor

21 January 2018

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Structure-based design of selective and potent inhibitors of protein-tyrosine phosphatase beta

21 January 2018

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Design and biological evaluation of linear and cyclic phosphopeptide ligands of the N-terminal SH2 domain of protein tyrosine phosphatase SHP-1.

21 January 2018

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Redox redux: revisiting PTPs and the control of cell signaling

21 January 2018

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Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins

21 January 2018

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The antioxidant function of the p53 tumor suppressor

21 January 2018

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Genetic ablation of protein tyrosine phosphatase 1B accelerates lymphomagenesis of p53-null mice through the regulation of B-cell development

21 January 2018

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Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate

21 January 2018

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Regulation of PTP1B via glutathionylation of the active site cysteine 215

21 January 2018

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Inhibition of protein-tyrosine phosphatases by mild oxidative stresses is dependent on S-nitrosylation.

21 January 2018

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Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo

21 January 2018

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Requirement for generation of H2O2 for platelet-derived growth factor signal transduction

21 January 2018

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Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor

21 January 2018

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Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascade

21 January 2018

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The strength of receptor signaling is centrally controlled through a cooperative loop between Ca2+ and an oxidant signal.

21 January 2018

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Inactivation of protein-tyrosine phosphatases as mechanism of UV-induced signal transduction

21 January 2018

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Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases

21 January 2018

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Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II

21 January 2018

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Differential oxidation of protein-tyrosine phosphatases.

21 January 2018

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Protein-tyrosine phosphatase epsilon. An isoform specifically expressed in mouse mammary tumors initiated by v-Ha-ras OR neu.

21 January 2018

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Inhibition of cell growth and spreading by stomach cancer-associated protein-tyrosine phosphatase-1 (SAP-1) through dephosphorylation of p130cas

21 January 2018

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Induction of apoptosis by stomach cancer-associated protein-tyrosine phosphatase-1.

21 January 2018

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Overexpression of leucocyte common antigen (LAR) P-subunit in thyroid carcinomas

21 January 2018

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The transmembrane protein-tyrosine phosphatase LAR modulates signaling by multiple receptor tyrosine kinases

21 January 2018

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Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines

21 January 2018

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The role of protein tyrosine phosphatase 1B in Ras signaling

21 January 2018

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Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts

21 January 2018

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Src Kinase Activity Is Regulated by the SHP-1 Protein-tyrosine Phosphatase

21 January 2018

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Involvement of the protein tyrosine phosphatase SHP-1 in Ras-mediated activation of the mitogen-activated protein kinase pathway.

21 January 2018

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Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase

21 January 2018

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Increased mRNA expression of the receptor-like protein tyrosine phosphatase α in late stage colon carcinomas

21 January 2018

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21 January 2018

Identifiers

DOI

10.1038/NRC1837

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14 August 2017

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