(Q34512601)

2 August 2017

title

NDR kinases regulate essential cell processes from yeast to humans. (English)

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2 August 2017

Alexander Hergovich

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2 August 2017

Mario R Stegert

series ordinal

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2 August 2017

Debora Schmitz

series ordinal

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2 August 2017

Brian A Hemmings

series ordinal

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2 August 2017

publication date

1 April 2006

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Nature Reviews Molecular Cell Biology

2 August 2017

published in

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2 August 2017

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2 August 2017

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2 August 2017

page(s)

253-264

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https://scigraph.springernature.com/pub.10.1038/nrm1891

2 August 2017

exact match

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cites work

The protein kinase complement of the human genome

1 reference

Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates.

21 January 2018

1 reference

Pag1p, a novel protein associated with protein kinase Cbk1p, is required for cell morphogenesis and proliferation in Saccharomyces cerevisiae

21 January 2018

1 reference

Initiation of cytokinesis is controlled through multiple modes of regulation of the Sid2p-Mob1p kinase complex

21 January 2018

1 reference

Mob2p interacts with the protein kinase Orb6p to promote coordination of cell polarity with cell cycle progression.

21 January 2018

1 reference

DBF2 protein kinase binds to and acts through the cell cycle-regulated MOB1 protein

21 January 2018

1 reference

Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex

21 January 2018

1 reference

The mitotic exit network Mob1p-Dbf2p kinase complex localizes to the nucleus and regulates passenger protein localization

21 January 2018

1 reference

The Saccharomyces cerevisiae Mob2p-Cbk1p kinase complex promotes polarized growth and acts with the mitotic exit network to facilitate daughter cell-specific localization of Ace2p transcription factor

21 January 2018

1 reference

Control of dendritic branching and tiling by the Tricornered-kinase/Furry signaling pathway in Drosophila sensory neurons.

21 January 2018

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Mechanosensory neurite termination and tiling depend on SAX-2 and the SAX-1 kinase.

21 January 2018

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The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis

21 January 2018

1 reference

Drosophila Mob family proteins interact with the related tricornered (Trc) and warts (Wts) kinases

21 January 2018

1 reference

The tricornered Ser/Thr protein kinase is regulated by phosphorylation and interacts with furry during Drosophila wing hair development

21 January 2018

1 reference

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

21 January 2018

1 reference

The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis

21 January 2018

1 reference

Control of cell proliferation and apoptosis by mob as tumor suppressor, mats

21 January 2018

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The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila.

21 January 2018

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Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway

21 January 2018

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hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts

21 January 2018

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Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein

21 January 2018

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The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1

21 January 2018

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Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases

21 January 2018

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HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases

21 January 2018

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Human NDR kinases are rapidly activated by MOB proteins through recruitment to the plasma membrane and phosphorylation

21 January 2018

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Calcium regulation of Ndr protein kinase mediated by S100 calcium-binding proteins

21 January 2018

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Ndr protein kinase is regulated by phosphorylation on two conserved sequence motifs

21 January 2018

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Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3

21 January 2018

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Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein

21 January 2018

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Mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase

21 January 2018

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The Cbk1p pathway is important for polarized cell growth and cell separation in Saccharomyces cerevisiae

21 January 2018

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"Mutagenesis" by peptide aptamers identifies genetic network members and pathway connections

21 January 2018

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The product of the Saccharomyces cerevisiae cell cycle gene DBF2 has homology with protein kinases and is periodically expressed in the cell cycle

21 January 2018

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Cbk1p, a protein similar to the human myotonic dystrophy kinase, is essential for normal morphogenesis in Saccharomyces cerevisiae

21 January 2018

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Sid2p, a spindle pole body kinase that regulates the onset of cytokinesis

21 January 2018

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Fission yeast orb6, a ser/thr protein kinase related to mammalian rho kinase and myotonic dystrophy kinase, is required for maintenance of cell polarity and coordinates cell morphogenesis with the cell cycle

21 January 2018

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The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation

21 January 2018

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Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity

21 January 2018

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Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction

21 January 2018

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Neuronal cell shape and neurite initiation are regulated by the Ndr kinase SAX-1, a member of the Orb6/COT-1/warts serine/threonine kinase family

21 January 2018

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Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma

21 January 2018

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Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers

21 January 2018

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Systematic variation in gene expression patterns in human cancer cell lines

21 January 2018

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Molecular cloning and characterization of a conserved nuclear serine(threonine) protein kinase

21 January 2018

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Human LATS1 is a mitotic exit network kinase

21 January 2018

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Regulation of the mitotic exit protein kinases Cdc15 and Dbf2.

21 January 2018

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RAM: a conserved signaling network that regulates Ace2p transcriptional activity and polarized morphogenesis

21 January 2018

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Fission yeast Mor2/Cps12, a protein similar to Drosophila Furry, is essential for cell morphogenesis and its mutation induces Wee1-dependent G(2) delay

21 January 2018

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Control of cell polarity in fission yeast by association of Orb6p kinase with the highly conserved protein methyltransferase Skb1p

21 January 2018

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The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors.

21 January 2018

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Neuronal functions of the novel serine/threonine kinase Ndr2

21 January 2018

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The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.

21 January 2018

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Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor

21 January 2018

1 reference

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

21 January 2018

1 reference

Structure of the Ca2+/S100B/NDR kinase peptide complex: insights into S100 target specificity and activation of the kinase

21 January 2018

1 reference

MOB1, an essential yeast gene required for completion of mitosis and maintenance of ploidy

21 January 2018

1 reference

NMR solution structure of Mob1, a mitotic exit network protein and its interaction with an NDR kinase peptide.

21 January 2018

1 reference

Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways

21 January 2018

1 reference

salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines

21 January 2018

1 reference

AF4p12, a human homologue to the furry gene of Drosophila, as a novel MLL fusion partner

21 January 2018

1 reference

Men and sin: what's the difference?

21 January 2018

1 reference

Mitotic-exit control as an evolved complex system

21 January 2018

1 reference

Timing is everything: regulation of mitotic exit and cytokinesis by the MEN and SIN.

21 January 2018

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Phosphatase 2A negatively regulates mitotic exit in Saccharomyces cerevisiae

21 January 2018

1 reference

Etd1p is a novel protein that links the SIN cascade with cytokinesis

21 January 2018

1 reference

Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation

21 January 2018

1 reference

Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity

21 January 2018

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LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1

21 January 2018

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Functional homology among human and fission yeast Cdc14 phosphatases.

21 January 2018

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Fission yeast MO25 protein is localized at SPB and septum and is essential for cell morphogenesis.

21 January 2018

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Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila

21 January 2018

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Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase

21 January 2018

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Regulation of mammalian STE20-like kinase 2 (MST2) by protein phosphorylation/dephosphorylation and proteolysis

21 January 2018

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Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis.

21 January 2018

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Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1

21 January 2018

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MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation

21 January 2018

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Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis

21 January 2018

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Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation

21 January 2018

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Identification of a novel Ras-regulated proapoptotic pathway

21 January 2018

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Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.

21 January 2018

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Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras

21 January 2018

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Inhibition of cell growth by conditional expression of kpm, a human homologue of Drosophila warts/lats tumor suppressor

21 January 2018

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Lats2, a putative tumor suppressor, inhibits G1/S transition

21 January 2018

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Human homologue of Drosophila lats, LATS1, negatively regulate growth by inducing G(2)/M arrest or apoptosis.

21 January 2018

1 reference

The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA Damage.

21 January 2018

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Mosaic Arrangement of Ganglion Cell Receptive Fields in Rabbit Retina

21 January 2018

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The Ste20 group kinases as regulators of MAP kinase cascades

21 January 2018

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Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation

21 January 2018

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Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST)

21 January 2018

1 reference

Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties

21 January 2018

1 reference

Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis

21 January 2018

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YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta

21 January 2018

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The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death

21 January 2018

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Mitotic exit regulation through distinct domains within the protein kinase Cdc15.

21 January 2018

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Nud1p links astral microtubule organization and the control of exit from mitosis

21 January 2018

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A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae.

21 January 2018

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Systematic trans-genomic comparison of protein kinases between Arabidopsis and Saccharomyces cerevisiae

21 January 2018

1 reference

Fission yeast cell morphogenesis: identification of new genes and analysis of their role during the cell cycle

21 January 2018

1 reference

The ukc1 gene encodes a protein kinase involved in morphogenesis, pathogenicity and pigment formation in Ustilago maydis

21 January 2018

1 reference

Conserved serine/threonine kinase encoded by CBK1 regulates expression of several hypha-associated transcripts and genes encoding cell wall proteins in Candida albicans

21 January 2018

1 reference

Pneumocystis carinii cell wall biosynthesis kinase gene CBK1 is an environmentally responsive gene that complements cell wall defects of cbk-deficient yeast

21 January 2018

1 reference

Trypanosoma brucei MOB1 is required for accurate and efficient cytokinesis but not for exit from mitosis

21 January 2018

1 reference

Cloning and characterization of a novel radish protein kinase which is homologous to fungal cot-I like and animal Ndr protein kinases

21 January 2018

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A highly conserved kinase is an essential component for stress tolerance in yeast and plant cells

21 January 2018

1 reference

Expression cloning of a variety of novel protein kinases in Lotus japonicus

21 January 2018

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Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function

21 January 2018

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The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell death

21 January 2018

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Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation

21 January 2018

1 reference

Saccharomyces cerevisiae Mob1p is required for cytokinesis and mitotic exit

21 January 2018

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Mitotic exit network controls the localization of Cdc14 to the spindle pole body in Saccharomyces cerevisiae

21 January 2018

1 reference

The role of the sid1p kinase and cdc14p in regulating the onset of cytokinesis in fission yeast

21 January 2018

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Sid4p-Cdc11p assembles the septation initiation network and its regulators at the S. pombe SPB.

21 January 2018

1 reference

The COT1 homologue CPCOT1 regulates polar growth and branching and is essential for pathogenicity in Claviceps purpurea

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1038/NRM1891

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Dimensions Publication ID

2 August 2017

1003152818

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