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Hepatitis C virus infection in the immunocompromised host: a complex scenario with variable clinical impact

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23 March 2019

21 March 2019

Hepatitis C virus infection in the immunocompromised host: a complex scenario with variable clinical impact (English)

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23 March 2019

21 March 2019

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Laura Gragnani

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Anna Linda Zignego

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author name string

Anna Linda Zignego

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Carlo Giannini

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Alessia Piluso

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Elisa Fognani

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2012

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3 August 2012

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23 March 2019

21 March 2019

Journal of Translational Medicine

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23 March 2019

21 March 2019

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158

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Creative Commons Attribution 2.0 Generic

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Europe PubMed Central

23 March 2019

Europe PubMed Central

21 March 2019

on focus list of Wikimedia project

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Binding of hepatitis C virus to CD81

1 reference

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19 March 2017

Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence

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19 March 2017

Activation of naïve B lymphocytes via CD81, a pathogenetic mechanism for hepatitis C virus-associated B lymphocyte disorders

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19 March 2017

Establishment of B-cell lymphoma cell lines persistently infected with hepatitis C virus in vivo and in vitro: the apoptotic effects of virus infection

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19 March 2017

Broad Specificity of Virus-Specific CD4+ T-Helper-Cell Responses in Resolved Hepatitis C Virus Infection

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19 March 2017

Inhibition of Natural Killer Cells through Engagement of CD81 by the Major Hepatitis C Virus Envelope Protein

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19 March 2017

Longitudinal variation in hepatitis C virus (HCV) viraemia and early course of HCV infection after liver transplantation for HCV cirrhosis: the role of different immunosuppressive regimens

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19 March 2017

Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein

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19 March 2017

Hepatitis C virus infection

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19 March 2017

Determinants of viral clearance and persistence during acute hepatitis C virus infection

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19 March 2017

Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection

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7 April 2017

Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups

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7 April 2017

Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection

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7 April 2017

Lack of Protective Immunity Against Reinfection with Hepatitis C Virus

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7 April 2017

Immunosuppression and HCV recurrence after liver transplantation

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27 September 2017

Treatment with rituximab in patients with mixed cryoglobulinemia syndrome: results of multicenter cohort study and review of the literature

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27 September 2017

Laboratory test results after living liver donation in the adult-to-adult living donor liver transplantation cohort study

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27 September 2017

Clonal B cells in patients with hepatitis C virus-associated mixed cryoglobulinemia contain an expanded anergic CD21low B-cell subset.

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27 September 2017

The impact of sirolimus on hepatitis C recurrence after liver transplantation

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27 September 2017

Persistent expression of the full genome of hepatitis C virus in B cells induces spontaneous development of B-cell lymphomas in vivo

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27 September 2017

A practical guide to the management of HCV infection following liver transplantation

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27 September 2017

Hepatitis C virus and disrupted interferon signaling promote lymphoproliferation via type II CD95 and interleukins

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27 September 2017

Cellular and molecular interactions in coinfection with hepatitis C virus and human immunodeficiency virus

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27 September 2017

Kaposi sarcoma in transplantation

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27 September 2017

Hepatitis C virus infection, mixed cryoglobulinemia and BLyS upregulation: targeting the infectious trigger, the autoimmune response, or both?

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27 September 2017

Hepatitis C virus core protein induces lipid droplet redistribution in a microtubule- and dynein-dependent manner.

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27 September 2017

Hepatitis C and non-Hodgkin lymphoma among 4784 cases and 6269 controls from the International Lymphoma Epidemiology Consortium

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27 September 2017

Management of viral hepatitis in hematologic malignancies

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27 September 2017

Hepatitis C virus (HCV) infection: a systemic disease.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441205

27 September 2017

Immunobiology and pathogenesis of viral hepatitis

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27 September 2017

Hepatitis C virus lymphotropism: lessons from a decade of studies.

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27 September 2017

Involvement of PI3K in HCV-related lymphoproliferative disorders

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27 September 2017

Hepatitis C virus-related lymphoproliferative disorders: an overview.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441205

27 September 2017

Extrahepatic manifestations of Hepatitis C Virus infection: a general overview and guidelines for a clinical approach

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27 September 2017

Mechanisms of liver injury. III. Oxidative stress in the pathogenesis of hepatitis C virus

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27 September 2017

Analysis of interleukin (IL)-1beta IL-1 receptor antagonist, soluble IL-1 receptor type II and IL-1 accessory protein in HCV-associated lymphoproliferative disorders.

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27 September 2017

Immunopathogenesis of hepatitis C virus infection: multifaceted strategies subverting innate and adaptive immunity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441205

27 September 2017

Influence of HIV co-infection on hepatitis C immunopathogenesis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441205

27 September 2017

HCV-associated B cell clonalities in the liver do not carry the t(14;18) chromosomal translocation.

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27 September 2017

Suppression of hepatitis C virus replication by cyclosporin a is mediated by blockade of cyclophilins

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27 September 2017

Immunosuppressive agents in solid organ transplantation: Mechanisms of action and therapeutic efficacy.

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27 September 2017

Hepatitis C virus antibody status and survival after renal transplantation: meta-analysis of observational studies

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441205

27 September 2017

Hepatitis C virus and the immune system: a concise review

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441205

27 September 2017

What determines the natural history of recurrent hepatitis C after liver transplantation?

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27 September 2017

Cell-mediated immunity and the outcome of hepatitis C virus infection

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27 September 2017

Role of NK and NKT cells in the immunopathogenesis of HCV-induced hepatitis.

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27 September 2017

Hepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and protooncogenes

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27 September 2017

The role of immunosuppression in recurrence of hepatitis C.

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27 September 2017

Report of the first International Liver Transplantation Society expert panel consensus conference on liver transplantation and hepatitis C.

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27 September 2017

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27 September 2017

Efficacy and safety of rituximab in type II mixed cryoglobulinemia

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27 September 2017

Immunopathogenesis of hepatitis C virus in the immunosuppressed host

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27 September 2017

Increased risk for posttransplant lymphoproliferative disease in recipients of liver transplants with hepatitis C.

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27 September 2017

Protection or damage: a dual role for the virus-specific cytotoxic T lymphocyte response in hepatitis B and C infection?

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27 September 2017

The role of virus-specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection

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27 September 2017

Natural killer cells in antiviral defense: function and regulation by innate cytokines

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27 September 2017

Cytotoxic T lymphocytes, chemokines and antiviral immunity

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27 September 2017

Hepatitis C virus as a lymphotropic agent: evidence and pathogenetic implications.

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27 September 2017

Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin

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27 September 2017

Cryoglobulinemia presenting after liver transplantation

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27 September 2017

Hepatitis C virus genotype analysis in patients with type II mixed cryoglobulinemia

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27 September 2017

Effect of calcineurin inhibitors in the outcome of liver transplantation in hepatitis C virus-positive recipients.

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30 May 2018

The association between hepatitis C infection and survival after orthotopic liver transplantation

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30 May 2018

Long-term outcome of chronic hepatitis C virus infection in primary hypogammaglobulinaemia

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30 May 2018

Liver dysfunction in patients infected with hepatitis C virus undergoing chemotherapy for hematologic malignancies

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30 May 2018

Predictors of patient and graft survival following liver transplantation for hepatitis C.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441205

30 May 2018

Hepatitis C virus persistence in human hematopoietic cells injected into SCID mice

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30 May 2018

Hepatitis C virus infection in mixed cryoglobulinemia and B-cell non-Hodgkin’s lymphoma: evidence for a pathogenetic role

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30 May 2018

Human immunodeficiency virus infection modifies the natural history of chronic parenterally-acquired hepatitis C with an unusually rapid progression to cirrhosis

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30 May 2018

Lack of preferential localization of tumoral mass in B-cell non-Hodgkin's lymphoma associated with hepatitis C virus infection.

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30 May 2018

Long-term outcome of hepatitis C infection after liver transplantation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441205

30 May 2018

Infection of peripheral mononuclear blood cells by hepatitis C virus

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30 May 2018

1 reference

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21 January 2018

Rapidly progressive HCV cirrhosis in a hypogammaglobulinemic patient

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21 January 2018

Intravenous immunoglobulin prophylaxis causing liver damage in 16 of 77 patients with hypogammaglobulinemia or IgG subclass deficiency

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21 January 2018

Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients. The Multivirc Group

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21 January 2018

Hepatitis C virus in long-term bone marrow transplant survivors

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21 January 2018

A score predicting survival after liver retransplantation for hepatitis C virus cirrhosis.

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21 January 2018

Role of Fas ligand in apoptosis induced by hepatitis C virus infection

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https://api.crossref.org/works/10.1186%2F1479-5876-10-158

21 January 2018

Caspase activation correlates with the degree of inflammatory liver injury in chronic hepatitis C virus infection

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21 January 2018

Frequencies of HCV-specific effector CD4+ T cells by flow cytometry: correlation with clinical disease stages

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21 January 2018

Hepatitis C virus in multiple episodes of acute hepatitis in polytransfused thalassaemic children

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21 January 2018

Clearance of hepatitis C viremia associated with cellular immunity in the absence of seroconversion in the hepatitis C incidence and transmission in prisons study cohort

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21 January 2018

Safety and efficacy of rituximab in patients with hepatitis C virus-related mixed cryoglobulinemia and severe liver disease.

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-10-158

21 January 2018

Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3.

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-10-158

21 January 2018

Hepatitis C virus infection in patients with non-Hodgkin's lymphoma

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-10-158

21 January 2018

Hepatitis-C-virus infection and cancer

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21 January 2018

Chronic hepatitis C and B-cell non-Hodgkin's lymphoma

1 reference

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21 January 2018

Hepatitis C virus and B-cell non-Hodgkin lymphomas: an Italian multicenter case-control study

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21 January 2018

Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection

1 reference

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21 January 2018

Viral elimination reduces incidence of malignant lymphoma in patients with hepatitis C.

1 reference

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21 January 2018

V(H)1-69 gene is preferentially used by hepatitis C virus-associated B cell lymphomas and by normal B cells responding to the E2 viral antigen

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21 January 2018

Elevated Serum Levels of Osteopontin in HCV-Associated Lymphoproliferative Disorders.

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21 January 2018

Genetic determinants in hepatitis C virus-associated mixed cryoglobulinemia: role of polymorphic variants of BAFF promoter and Fcγ receptors

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21 January 2018

Enhanced expression of lymphomagenesis-related genes in peripheral blood B cells of chronic hepatitis C patients

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21 January 2018

Expression of hepatitis C virus core protein associated with malignant lymphoma in transgenic mice

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21 January 2018

T(14;18) translocation in chronic hepatitis C virus infection

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21 January 2018

bcl-2 and immunoglobulin gene rearrangement in patients with hepatitis C virus infection

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21 January 2018

Association of t(14;18) translocation with HCV infection in gastrointestinal MALT lymphomas.

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21 January 2018

Effect of antiviral treatment in patients with chronic HCV infection and t(14;18) translocation

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21 January 2018

Association between mixed cryoglobulinemia, translocation (14;18), and persistence of occult HCV lymphoid infection after treatment

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-10-158

21 January 2018

Association between persistent lymphatic infection by hepatitis C virus after antiviral treatment and mixed cryoglobulinemia

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-10-158

21 January 2018

Glucocorticosteroids increase cell entry by hepatitis C virus

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-10-158

21 January 2018

Hepatitis C virus entry and glucocorticosteroids

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-10-158

21 January 2018

A randomized, multicenter study comparing steroid-free immunosuppression and standard immunosuppression for liver transplant recipients with chronic hepatitis C

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-10-158

21 January 2018

Steroid avoidance in liver transplantation: meta-analysis and meta-regression of randomized trials

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-10-158

21 January 2018

Predicting factors for long-term results of OKT3 therapy in steroid-resistant acute rejection following cadaveric renal transplantation

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-10-158

21 January 2018

Insulin resistance, serum adipokines and risk of fibrosis progression in patients transplanted for hepatitis C.

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-10-158

21 January 2018

Report of the monothematic EASL conference on liver transplantation for viral hepatitis (Paris, France, January 12-14, 2006).

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-10-158

21 January 2018

Cyclosporine versus Tacrolimus Treated Liver Transplant Recipients with Chronic Hepatitis C: Outcomes Analysis of the UNOS/OPTN Database

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-10-158

21 January 2018

12-month follow-up analysis of a multicenter, randomized, prospective trial in de novo liver transplant recipients (LIS2T) comparing cyclosporine microemulsion (C2 monitoring) and tacrolimus

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-10-158

21 January 2018

Impact of hepatitis B and C virus on kidney transplantation outcome

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-10-158

21 January 2018

Outcomes of a patient-to-patient outbreak of genotype 3a hepatitis C.

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-10-158

21 January 2018

Hepatic toxicity and prognosis in hepatitis C virus-infected patients with diffuse large B-cell lymphoma treated with rituximab-containing chemotherapy regimens: a Japanese multicenter analysis

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-10-158

21 January 2018

Lymphotropic Virus Infection of Peripheral Blood Mononuclear Cells in B-Cell Non-Hodgkin’s Lymphoma

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-10-158

21 January 2018

Rituximab for the treatment of type II mixed cryoglobulinemia

1 reference

https://api.crossref.org/works/10.1186%2F1479-5876-10-158

21 January 2018

Hepatitis C virus infection prevalence and liver dysfunction in a cohort of B-cell non-Hodgkin's lymphoma patients treated with immunochemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441205

29 November 2018

Increased hepatitis C viral load and reactivation of liver disease in HCV RNA-positive patients with onco-haematological disease undergoing chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441205

29 November 2018

Hot topic in hepatitis C virus research: The type of immunosuppression does not matter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441205

29 November 2018

Impact of treatment-related liver toxicity on the outcome of HCV-positive non-Hodgkin's lymphomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441205

29 November 2018

Hepatitis C virus drives the unconstrained monoclonal expansion of VH1-69-expressing memory B cells in type II cryoglobulinemia: a model of infection-driven lymphomagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441205

29 November 2018

Frequent joining of Bcl-2 to a JH6 gene in hepatitis C virus-associated t(14;18).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441205

29 November 2018

Prevalence of bcl-2 rearrangement in patients with hepatitis C virus-related mixed cryoglobulinemia with or without B-cell lymphomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441205

29 November 2018

Sequence analysis of the immunoglobulin antigen receptor of hepatitis C virus-associated non-Hodgkin lymphomas suggests that the malignant cells are derived from the rheumatoid factor-producing cells that occur mainly in type II cryoglobulinemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441205

29 November 2018

Prevalence of monoclonal gammopathies in patients with hepatitis C virus infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441205

29 November 2018

Somatic hypermutation, clonal diversity, and preferential expression of the VH 51p1/VL kv325 immunoglobulin gene combination in hepatitis C virus-associated immunocytomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441205

29 November 2018

Use of OKT3 is associated with early and severe recurrence of hepatitis C after liver transplantation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441205

29 November 2018

Interferon-alpha in mixed cryoglobulinemia patients: a randomized, crossover-controlled trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441205

29 November 2018

Infection of peripheral blood mononuclear cells by hepatitis C virus in mixed cryoglobulinemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441205

29 November 2018

Non-Hodgkin's lymphoma: possible role of hepatitis C virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441205

29 November 2018

Hepatitis C virus infection and B-cell lymphomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441205

29 November 2018

Immunohistochemical detection of Fas antigen in liver tissue of patients with chronic hepatitis C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3441205

29 November 2018

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10.1186/1479-5876-10-158

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