Abstract
In the spring of 2016, a loss of wild birds was observed during the monitoring of avian influenza virus activity in the Republic of Tyva. That outbreak was caused by influenza H5N8 virus of clade 2.3.4.4. In the fall, viruses of H5N8 clade 2.3.4.4 were propagated in European countries. This paper presents some results of analysis of the virus strains isolated during the spring and fall seasons in 2016 in the Russian Federation. The investigated strains were highly pathogenic for mice, and some of their antigenic and genetic features differed from those of an H5N8 strain that circulated in 2014 in Russia.
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Acknowledgements
The authors thank Dr. Richard Webby (St. Jude Children’s Research Hospital, Memphis, TN) for providing the reference antigens and sera. We thank Andrey Varkentin and Yuriy Lobkov (Federal Centre for Animal Health, Vladimir, Russia) for assistance in sample collection. Construction of the tree was done using HA gene sequences deposited in GISAID. We are grateful to GISAID’s EpiFlu™ Database (http://www.gisaid.org) and to the authors who provided sequence information.
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This study was funded by RFBR through research project No. 16-34-60073 mol_a_dk. Phylogenic analysis was partially supported by Russian Science Foundation Grant 15-15-00047.
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The authors declare that they have no conflict of interest.
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All applicable international, national and institutional guidelines for the care and use of animals were followed. This article does not contain any studies with human participants performed by any of the authors.
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Marchenko, V.Y., Susloparov, I.M., Komissarov, A.B. et al. Reintroduction of highly pathogenic avian influenza A/H5N8 virus of clade 2.3.4.4. in Russia. Arch Virol 162, 1381–1385 (2017). https://doi.org/10.1007/s00705-017-3246-z
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DOI: https://doi.org/10.1007/s00705-017-3246-z