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Rhodopsin

Dari Wikipedia bahasa Indonesia, ensiklopedia bebas
Rhodopsin

Rhodopsin adalah pigmen yang ada di sel fotoreseptor dari organ retina yang bertanggung jawab terhadap persepsi cahaya. Rhodopsin masuk dalam keluarga reseptor protein berpasangan G dan sangat sensitiv terhadap cahaya, yang mampu menangkap cahaya yang rendah.[1] Saat terkena cahaya, pigmennya akan segera mengalami fotoblecing dan manusia memerlukan waktu sekitar 30 menit untuk melakukan hal ini.[2]

Rhodopsin terdiri dari gugus fungsional opsin dan sebuah ikatan kovalen alkanal vitamin A yang terbalik. Opsin, sebuah ikatan dari tujuh transmembran heliks terikat satu sama lain oleh lingkaran protein, mengikat fotoreaktif retina yang terletak di pusat pada residu linisa.


Referensi

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  1. ^ Litmann BJ, Mitchell DC (1996). "Rhodopsin structure and function". Dalam Lee AG. Rhodopsin and G-Protein Linked Receptors, Part A (Vol 2, 1996) (2 Vol Set). Greenwich, Conn: JAI Press. hlm. 1–32. ISBN 1-55938-659-2. 
  2. ^ Stuart JA, Brige RR (1996). "Characterization of the primary photochemical events in bacteriorhodopsin and rhodopsin". Dalam Lee AG. Rhodopsin and G-Protein Linked Receptors, Part A (Vol 2, 1996) (2 Vol Set). Greenwich, Conn: JAI Press. hlm. 33–140. ISBN 1-55938-659-2. 

Baca juga

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  • (Inggris) Humphries P, Kenna P, Farrar GJ (1992). "On the molecular genetics of retinitis pigmentosa". Science. 256 (5058): 804–8. doi:10.1126/science.1589761. PMID 1589761. 
  • (Inggris) Edwards SC (1995). "Involvement of cGMP and calcium in the photoresponse in vertebrate photoreceptor cells". The Journal of the Florida Medical Association. 82 (7): 485–8. PMID 7673885. 
  • (Inggris) al-Maghtheh M, Gregory C, Inglehearn C; et al. (1993). "Rhodopsin mutations in autosomal dominant retinitis pigmentosa". Hum. Mutat. 2 (4): 249–55. doi:10.1002/humu.1380020403. PMID 8401533. 
  • (Inggris) Garriga P, Manyosa J (2002). "The eye photoreceptor protein rhodopsin. Structural implications for retinal disease". FEBS Lett. 528 (1–3): 17–22. doi:10.1016/S0014-5793(02)03241-6. PMID 12297272. 
  • (Inggris) Mendes HF, van der Spuy J, Chapple JP, Cheetham ME (2005). "Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapy". Trends in molecular medicine. 11 (4): 177–85. doi:10.1016/j.molmed.2005.02.007. PMID 15823756. 
  • (Inggris) Inglehearn CF, Keen TJ, Bashir R; et al. (1993). "A completed screen for mutations of the rhodopsin gene in a panel of patients with autosomal dominant retinitis pigmentosa". Hum. Mol. Genet. 1 (1): 41–5. doi:10.1093/hmg/1.1.41. PMID 1301135. 
  • (Inggris) Farrar GJ, Findlay JB, Kumar-Singh R; et al. (1993). "Autosomal dominant retinitis pigmentosa: a novel mutation in the rhodopsin gene in the original 3q linked family". Hum. Mol. Genet. 1 (9): 769–71. doi:10.1093/hmg/1.9.769. PMID 1302614. 
  • (Inggris) Robinson PR, Cohen GB, Zhukovsky EA, Oprian DD (1992). "Constitutively active mutants of rhodopsin". Neuron. 9 (4): 719–25. doi:10.1016/0896-6273(92)90034-B. PMID 1356370. 
  • (Inggris) Fujiki K, Hotta Y, Hayakawa M; et al. (1992). "Point mutations of rhodopsin gene found in Japanese families with autosomal dominant retinitis pigmentosa (ADRP)". Jpn. J. Hum. Genet. 37 (2): 125–32. doi:10.1007/BF01899733. PMID 1391967. 
  • (Inggris) Olsson JE, Gordon JW, Pawlyk BS; et al. (1992). "Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa". Neuron. 9 (5): 815–30. doi:10.1016/0896-6273(92)90236-7. PMID 1418997. 
  • (Inggris) Andréasson S, Ehinger B, Abrahamson M, Fex G (1993). "A six-generation family with autosomal dominant retinitis pigmentosa and a rhodopsin gene mutation (arginine-135-leucine)". Ophthalmic paediatrics and genetics. 13 (3): 145–53. doi:10.3109/13816819209046483. PMID 1484692. 
  • (Inggris) Inglehearn CF, Lester DH, Bashir R; et al. (1992). "Recombination between rhodopsin and locus D3S47 (C17) in rhodopsin retinitis pigmentosa families". Am. J. Hum. Genet. 50 (3): 590–7. PMC 1684283alt=Dapat diakses gratis. PMID 1539595. 
  • (Inggris) Fishman GA, Stone EM, Gilbert LD, Sheffield VC (1992). "Ocular findings associated with a rhodopsin gene codon 106 mutation. Glycine-to-arginine change in autosomal dominant retinitis pigmentosa". Arch. Ophthalmol. 110 (5): 646–53. PMID 1580841. 
  • (Inggris) Keen TJ, Inglehearn CF, Lester DH; et al. (1992). "Autosomal dominant retinitis pigmentosa: four new mutations in rhodopsin, one of them in the retinal attachment site". Genomics. 11 (1): 199–205. doi:10.1016/0888-7543(91)90119-Y. PMID 1765377. 
  • (Inggris) Dryja TP, Hahn LB, Cowley GS; et al. (1991). "Mutation spectrum of the rhodopsin gene among patients with autosomal dominant retinitis pigmentosa". Proc. Natl. Acad. Sci. U.S.A. 88 (20): 9370–4. doi:10.1073/pnas.88.20.9370. PMC 52716alt=Dapat diakses gratis. PMID 1833777. 
  • (Inggris) Gal A, Artlich A, Ludwig M; et al. (1992). "Pro-347-Arg mutation of the rhodopsin gene in autosomal dominant retinitis pigmentosa". Genomics. 11 (2): 468–70. doi:10.1016/0888-7543(91)90159-C. PMID 1840561. 
  • (Inggris) Sung CH, Davenport CM, Hennessey JC; et al. (1991). "Rhodopsin mutations in autosomal dominant retinitis pigmentosa". Proc. Natl. Acad. Sci. U.S.A. 88 (15): 6481–5. doi:10.1073/pnas.88.15.6481. PMC 52109alt=Dapat diakses gratis. PMID 1862076. 
  • (Inggris) Jacobson SG, Kemp CM, Sung CH, Nathans J (1991). "Retinal function and rhodopsin levels in autosomal dominant retinitis pigmentosa with rhodopsin mutations". Am. J. Ophthalmol. 112 (3): 256–71. PMID 1882937. 
  • (Inggris) Sheffield VC, Fishman GA, Beck JS; et al. (1991). "Identification of novel rhodopsin mutations associated with retinitis pigmentosa by GC-clamped denaturing gradient gel electrophoresis". Am. J. Hum. Genet. 49 (4): 699–706. PMC 1683182alt=Dapat diakses gratis. PMID 1897520. 

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