Chloramphenicol

Chloramphenicol (INN)
Reglubundið (IUPAC) navn
	2,2-dichloro-N-[1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
Clinical data
Vørunavn	Pentamycetin, Chloromycetin
AHFS/Drugs.com	monograph
MedlinePlus	a608008
Loyvi dáta	US FDA:link
Viðgongutíð; bólkur	AU: A ; US: C (Vandi ikki útilokaður) ; ;
Legal status	AU: S4 (Bara við resept) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Máti at; taka heilivágin	Lokalt (eygnadropar), við, IV, IM
Pharmacokinetic data
Bioavailability	75–90%
Protein binding	60%
Evnaskifti	Livur
Helvtartíð	1.6-3.3 hours
Úrskiljing	Nýru (5-15%), skarn (4%)
Identifiers
CAS Nummar	56-75-7
ATC code	D06AX02 D10AF03 G01AA05 J01BA01 S01AA01 S02AA01 S03AA08 QJ51BA01
PubChem	CID 298
DrugBank	DB00446
ChemSpider	5744
UNII	66974FR9Q1
KEGG	D00104
ChEBI	CHEBI:17698
ChEMBL	CHEMBL130
Chemical data
Formula	C11H12Cl2N2O5
Molar mass	323.1320 g/mol
	SMILES c1cc(ccc1[C@H]([C@@H](CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]; ;
	InChI InChI=1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1 ; Key:WIIZWVCIJKGZOK-RKDXNWHRSA-N ;
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Chloramphenicol er eitt slag av antibiotika. Tað virkar við at binda til bakteriu ribosomið og forða fyri ensyminum peptidyl transferase. Tað hevur tann fyrimunin eisini at ávirka (eukaryotar) menniskjakyknur og kann tí nýtast ímóti bakterium, ið goyma seg inni í menniskjakyknum. Tað verður tó sjáldan nýtt longur í framkomnum londum, vegna sjáldsama, men álvarsliga hjáárinið blóðmangul.

Keldur

S. P. Denyer, N. A. Hodges, S. P. Gorman, Hugo & Russel's Pharmaceutical Microbiology, 7th Edition, 2004, Blackwell Publishing.

Slóðir úteftir

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