SMARCA2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
	; Estructura tridimensional de la proteína SMARCA2.
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 2dat
Identificadores
Símbolos	SMARCA2 (HGNC: 11098) SWI2, BAF190, BRM, FLJ36757, MGC74511, SNF2, SNF2L2, SNF2LA, Sth1p, hBRM, hSNF2a
Identificadores; externos	OMIM: 600014 ; EBI: SMARCA2; GeneCards: Gen SMARCA2; UniProt: SMARCA2;
Locus	Cr. 9 p24.3
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
6595
P51531	n/a
NP_003061	n/a
	v; t; e;
	[editar datos en Wikidata]

El activador probable de transcripción global SNF2L2 (SMARCA2) es una ´proteína codificada en humanos por el gen smarca2.^[1]^[2]

Esta proteína pertenece a la familia de proteínas SWI/SNF y presenta un alto grado de identidad con la proteína brahmā de Drosophila. Los miembros de esta familia presentan actividad helicasa y ATPasa y parecen estar implicados en la regulación de la transcripción de ciertos genes por medio de la alteración de la estructura de la cromatina alrededor de dichos genes. SMARCA2 forma parte de un complejo implicado en la remodelación de la cromatina dependiente de ATP, que está implicado en la activación transcripcional de genes normalmente reprimidos por la cromatina. Se han descrito dos transcritos alternativos que codifican dos isoformas diferentes de SMARCA2. También se ha descrito la presencia de un polimorfismo consistente en la repetición de un trinucleótido (CAG).^[2]

Interacciones

La proteína SMARCA2 ha demostrado ser capaz de interaccionar con:

Referencias

↑ Muchardt C, Yaniv M, Mattei MG (Jul de 1994). «Assignment of HBRM, the human homolog of S. cerevisiae SNF2/SWI2 and Drosophila brm genes, to chromosome region 9p23-p24, by in situ hybridization». Mamm Genome 5 (4): 241-3. PMID 8012116.
↑ ^a ^b «Entrez Gene: SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2».
↑ Perani, Michela; Ingram Catherine J E, Cooper Colin S, Garrett Michelle D, Goodwin Graham H (Nov. de 2003). «Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers». Oncogene (England) 22 (50): 8156-67. ISSN 0950-9232. PMID 14603256. doi:10.1038/sj.onc.1207031.
↑ ^a ^b ^c ^d Wang, W; Côté J, Xue Y, Zhou S, Khavari P A, Biggar S R, Muchardt C, Kalpana G V, Goff S P, Yaniv M, Workman J L, Crabtree G R (Oct. de 1996). «Purification and biochemical heterogeneity of the mammalian SWI-SNF complex». EMBO J. (ENGLAND) 15 (19): 5370-82. ISSN 0261-4189. PMID 8895581.
↑ Park, Jeonghyeon; Wood Marcelo A, Cole Michael D (Mar. de 2002). «BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation». Mol. Cell. Biol. (United States) 22 (5): 1307-16. ISSN 0270-7306. PMID 11839798.
↑ Kuroda, Yukiko; Oma Yukako, Nishimori Katsuhiko, Ohta Tsutomu, Harata Masahiko (Nov. de 2002). «Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex». Biochem. Biophys. Res. Commun. (United States) 299 (2): 328-34. ISSN 0006-291X. PMID 12437990.
↑ ^a ^b ^c ^d Sif, S; Saurin A J, Imbalzano A N, Kingston R E (Mar. de 2001). «Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes». Genes Dev. (United States) 15 (5): 603-18. ISSN 0890-9369. PMID 11238380. doi:10.1101/gad.872801.
↑ Cho, H; Orphanides G, Sun X, Yang X J, Ogryzko V, Lees E, Nakatani Y, Reinberg D (Sep. de 1998). «A human RNA polymerase II complex containing factors that modify chromatin structure». Mol. Cell. Biol. (UNITED STATES) 18 (9): 5355-63. ISSN 0270-7306. PMID 9710619.
↑ Wang, Sheng; Zhang Baohua, Faller Douglas V (Jun. de 2002). «Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth». EMBO J. (England) 21 (12): 3019-28. ISSN 0261-4189. PMID 12065415. doi:10.1093/emboj/cdf302.
↑ Kowenz-Leutz, E; Leutz A (Nov. de 1999). «A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes». Mol. Cell (UNITED STATES) 4 (5): 735-43. ISSN 1097-2765. PMID 10619021.
↑ Inoue, Hiroko; Furukawa Takako, Giannakopoulos Stavros, Zhou Sharleen, King David S, Tanese Naoko (Nov. de 2002). «Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors». J. Biol. Chem. (United States) 277 (44): 41674-85. ISSN 0021-9258. PMID 12200431. doi:10.1074/jbc.M205961200.

Datos: Q18031593

[pmid8012116-1] Muchardt C, Yaniv M, Mattei MG (Jul de 1994). «Assignment of HBRM, the human homolog of S. cerevisiae SNF2/SWI2 and Drosophila brm genes, to chromosome region 9p23-p24, by in situ hybridization». Mamm Genome 5 (4): 241-3. PMID 8012116.

[entrez-2] «Entrez Gene: SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2».

[pmid14603256-3] Perani, Michela; Ingram Catherine J E, Cooper Colin S, Garrett Michelle D, Goodwin Graham H (Nov. de 2003). «Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers». Oncogene (England) 22 (50): 8156-67. ISSN 0950-9232. PMID 14603256. doi:10.1038/sj.onc.1207031.

[pmid8895581-4] Wang, W; Côté J, Xue Y, Zhou S, Khavari P A, Biggar S R, Muchardt C, Kalpana G V, Goff S P, Yaniv M, Workman J L, Crabtree G R (Oct. de 1996). «Purification and biochemical heterogeneity of the mammalian SWI-SNF complex». EMBO J. (ENGLAND) 15 (19): 5370-82. ISSN 0261-4189. PMID 8895581.

[pmid11839798-5] Park, Jeonghyeon; Wood Marcelo A, Cole Michael D (Mar. de 2002). «BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation». Mol. Cell. Biol. (United States) 22 (5): 1307-16. ISSN 0270-7306. PMID 11839798.

[pmid12437990-6] Kuroda, Yukiko; Oma Yukako, Nishimori Katsuhiko, Ohta Tsutomu, Harata Masahiko (Nov. de 2002). «Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex». Biochem. Biophys. Res. Commun. (United States) 299 (2): 328-34. ISSN 0006-291X. PMID 12437990.

[pmid11238380-7] Sif, S; Saurin A J, Imbalzano A N, Kingston R E (Mar. de 2001). «Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes». Genes Dev. (United States) 15 (5): 603-18. ISSN 0890-9369. PMID 11238380. doi:10.1101/gad.872801.

[pmid9710619-8] Cho, H; Orphanides G, Sun X, Yang X J, Ogryzko V, Lees E, Nakatani Y, Reinberg D (Sep. de 1998). «A human RNA polymerase II complex containing factors that modify chromatin structure». Mol. Cell. Biol. (UNITED STATES) 18 (9): 5355-63. ISSN 0270-7306. PMID 9710619.

[pmid12065415-9] Wang, Sheng; Zhang Baohua, Faller Douglas V (Jun. de 2002). «Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth». EMBO J. (England) 21 (12): 3019-28. ISSN 0261-4189. PMID 12065415. doi:10.1093/emboj/cdf302.

[pmid10619021-10] Kowenz-Leutz, E; Leutz A (Nov. de 1999). «A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes». Mol. Cell (UNITED STATES) 4 (5): 735-43. ISSN 1097-2765. PMID 10619021.

[pmid12200431-11] Inoue, Hiroko; Furukawa Takako, Giannakopoulos Stavros, Zhou Sharleen, King David S, Tanese Naoko (Nov. de 2002). «Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors». J. Biol. Chem. (United States) 277 (44): 41674-85. ISSN 0021-9258. PMID 12200431. doi:10.1074/jbc.M205961200.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]