misfold

 

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protein folding

Wikipedia

From mis- +‎ fold.

• (verb) IPA^(key): /mɪsˈfoʊld/

• Audio (Southern England):

  (file)

• (noun) IPA^(key): /ˈmɪsfoʊld/

• Audio (Southern England):

  (file)

misfold (third-person singular simple present misfolds, present participle misfolding, simple past and past participle misfolded)

1. (biochemistry, intransitive, of a protein or nucleic acid) To fold into an unusual or incorrect tertiary structure; misfolded proteins occur in various diseases, including amyloidoses and dementias, although the question of causation versus consequence is not yet definitively answered for dementias.
   • 2021 March 1, Anderson, K.N., Overcast, W.B., Brosch, J.R., Graner, B.D., Veronesi, M.C., “Prionopathies and Prionlike Protein Aberrations in Neurodegenerative Diseases”, in American Society of Neuroradiology, volume 11, number 2, →DOI, pages 127-148:

     The prionopathies are best known among the neurodegenerative diseases for their ability to misfold, self-propagate, and infect other organisms.

misfold (plural misfolds)

1. An incorrect or abnormal folding.