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==Bannered routes==
{{main|Bannered routes of U.S. Route 521}}
===Andrews business loop===
{{Infobox road small
|state=NC
|type=US
|subtype=Bus
|route=521
|location=[[Andrews, South Carolina]]
|formed=
|length_mi=3.2
|length_round=1
|length_ref=<ref>{{google maps|url=http://maps.google.com/maps?f=d&source=s_d&saddr=US-521+N%2FGeorgetown+Hwy&daddr=W+Main+St&hl=en&geocode=FXck_gEdBndC-w%3BFRCG_gEd_sRB-w&mra=me&mrcr=0&mrsp=1,0&sz=16&sll=33.455559,-79.573781&sspn=0.013373,0.027874&ie=UTF8&ll=33.447342,-79.553032&spn=0.053498,0.111494&z=14|title=US 521 Business - Andrews|accessdate=February 2, 2011}}</ref>
}}
It is a {{convert|3.2|mi|km}} route follows the old US 521 mainline route through downtown Andrews, via Main Street.
{{-}}
===Sumter connector===
{{Infobox road small
|state=NC
|type=US
|subtype=Conn
|route=521
|location=[[Sumter, South Carolina]]
|formed=
|length_mi=4.7
|length_round=1
|length_ref=<ref>{{google maps|url=http://maps.google.com/maps?f=d&source=s_d&saddr=S+Guignard+Dr&daddr=Unknown+road&hl=en&geocode=FVD_BAIdTvE1-w%3BFQL1BQIdyJw1-w&mra=me&mrcr=0&mrsp=1,0&sz=17&sll=33.944116,-80.369872&sspn=0.006649,0.013937&ie=UTF8&ll=33.90889,-80.322247&spn=0.106422,0.222988&z=13|title=US 521 Connector - Sumter|accessdate=February 2, 2011}}</ref>
}}
It is a {{convert|4.7|mi|km}} spur route that goes east around Sumter (along Guignard Drive), connecting to [[U.S. Route 15 in South Carolina|US 15]], in the south-end of Sumter.
{{-}}
===Camden truck route===
{{Infobox road small
|state=SC
|type=US
|route=521
|subtype=Truck
|location=[[Camden, South Carolina]]
|formed=
|length_mi=6.9
|length_round=1
|length_ref=<ref>{{google maps|url=https://maps.google.com/maps?saddr=US-521+N%2FSumter+Hwy&daddr=34.245359,-80.622755+to:34.2857464,-80.6266598+to:N+Broad+St&hl=en&ll=34.263033,-80.5933&spn=0.115341,0.222988&sll=34.274418,-80.622096&sspn=0.028831,0.055747&geocode=FVxSCgIdLQ4y-w%3BFe-KCgIdXcsx-ylxl_86rvBViDFPNvxWk3CjRw%3BFbIoCwIdHbwx-ynPiJplfvBViDGidqOg-aKhBw%3BFVA7CwId7vcx-w&mra=dpe&mrsp=2&sz=15&via=1,2&t=p&z=13|title=US 521 Truck - Camden|accessdate=January 27, 2013}}</ref>
}}
'''U.S. Route 521 Truck''' is an alternate route for trucks to avoid downtown Camden. The route takes various roads including: Ehrenclou Drive, Chestnut Ferry Road, Jefferson Davis Highway (in concurrency with [[U.S. Route 1 in South Carolina|US 1]]/[[U.S. Route 601 in South Carolina|US 601]]/[[South Carolina Highway 34|SC 34]]), Springdale Drive, and Boykin Road (in concurrency with [[U.S. Route 601 Truck (Camden, South Carolina)|US 601 Truck]]).
{{-}}
===Kershaw business loop===
{{Infobox road small
|state=NC
|type=US
|subtype=Bus
|route=521
|location=[[Kershaw, South Carolina]]
|formed=
|length_mi=1.4
|length_round=1
|length_ref=<ref>{{google maps|url=http://maps.google.com/maps?saddr=Matson+St&daddr=34.551255,-80.58357+to:Unknown+road&hl=en&ll=34.550998,-80.576906&spn=0.029585,0.055747&sll=34.561372,-80.585264&sspn=0.00736,0.013937&geocode=FZgQDwIdcWky-w%3BFdc1DwIdbmQy-yndbi7aqMNViDFznWyiGYB_dA%3BFepeDwIdFFUy-w&vpsrc=6&mra=me&mrsp=1,0&sz=17&t=p&z=15&via=1|title=US 521 Business - Kershaw|accessdate=January 15, 2012}}</ref>
}}
Following the old US 521 mainline route, this {{convert|1.4|mi|km}} business loop, in concurrency with [[U.S. Route 601 Business (Kershaw, South Carolina)|US 601 Business]], goes through downtown Kershaw, via Hampton Street.<ref name=Mapmikey/>
{{-}}
===Lancaster business loop===
{{Infobox road small
|state=NC
|type=US
|subtype=Bus
|route=521
|location=[[Lancaster, South Carolina]]
|formed=1965
|length_mi=3.8
|length_round=1
|length_ref=<ref>{{google maps|url=http://maps.google.com/maps?f=d&source=s_d&saddr=US-521+N%2FKershaw+Camden+Hwy&daddr=34.7088259,-80.7642961+to:34.7185482,-80.7698236+to:N+Main+St&hl=en&geocode=FfBbEQIdlPov-w%3BFVmdEQIdeKIv-yk9DcBAdddViDFbyVzTPtRm1g%3BFVTDEQId4Ywv-ylxsZbzptdViDE3IlTEPHvHww%3BFZAGEgIdhm0v-w&mra=dme&mrcr=0&mrsp=3&sz=15&via=1,2&sll=34.729445,-80.765734&sspn=0.026347,0.055747&ie=UTF8&ll=34.715371,-80.7514&spn=0.105405,0.222988&z=13|title=US 521 Business - Lancaster|accessdate=February 2, 2011}}</ref>
}}
Following the old US 521 mainline route, this {{convert|3.8|mi|km}} business loop goes through downtown Lancaster, via Main Street.<ref name=Mapmikey/>
{{-}}
==See also==
|