Willcox is a surname. Notable people with the surname include:
- Anita Parkhurst Willcox, American artist, feminist and pacifist
- Sir Charles Willcox, South Australian businessman and politician, and a mayor of the City of Adelaide
- Cornelis DeWitt Willcox, American soldier and military writer
- Louise Collier Willcox (1865-1929), American author, editor, anthologist, translator, suffragist
- Mary Alice Willcox, American zoologist
- Orlando Bolivar Willcox, American Civil War general
- Peter Willcox, American Greenpeace activist
- Reece Willcox, Canadian ice hockey player
- Sheila Willcox, British equestrian
- Spiegle Willcox, American jazz saxophonist
- Tim Willcox, British television personality
- Thomas Willcox (1689-1779), American colonial-era paper mill owner
- Toyah Willcox, British singer and actress
- Walter Francis Willcox, American statistician