Transcription factor II F

general transcription factor IIF, polypeptide 2, 30kDa
general transcription factor IIF, polypeptide 2, 30kDa
Identifiers
Symbol	GTF2F2
Alt. symbols	TFIIF, BTF4, RAP30
NCBI gene	2963
HGNC	4653
OMIM	189969
RefSeq	NM_004128
UniProt	P13984
Other data
Locus	Chr. 13 q14
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Search for
Structures	Swiss-model
Domains	InterPro

general transcription factor IIF, polypeptide 1, 74kDa
general transcription factor IIF, polypeptide 1, 74kDa
Identifiers
Symbol	GTF2F1
Alt. symbols	TFIIF, BTF4, RAP74
NCBI gene	2962
HGNC	4652
OMIM	189968
RefSeq	NM_002096
UniProt	P35269
Other data
Locus	Chr. 19 p13.3
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Transcription factor II F (TF_IIF) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.^[1]^[2]^[3]

general transcription factor IIF, polypeptide 2-like
Identifiers
Symbol	GTF2F2L
Alt. symbols	TFIIF
NCBI gene	2964
HGNC	4654
RefSeq	NG_003013
Other data
Locus	Chr. 4 q31.22

TF_IIF is encoded by the GTF2F1, GTF2F2, and GTF2F2L genes.^[4]^[5]^[6]

TF_IIF binds to RNA polymerase II when the enzyme is already unbound to any other transcription factor, thus preventing it from contacting DNA outside the promoter. Furthermore, TF_IIF stabilizes the RNA polymerase II while it's contacting TBP and TF_IIB.

References

^ Lewin, Benjamin (2004). Genes VIII. Upper Saddle River, NJ: Pearson Prentice Hall. pp. 636–637. ISBN 0-13-144946-X.
^ Lee TI, Young RA (2000). "Transcription of eukaryotic protein-coding genes". Annu. Rev. Genet. 34: 77–137. doi:10.1146/annurev.genet.34.1.77. PMID 11092823.
^ Kim TK, Lagrange T, Wang YH, Griffith JD, Reinberg D, Ebright RH (1997). "Trajectory of DNA in the RNA polymerase II transcription preinitiation complex". Proc Natl Acad Sci USA. 94 (23): 12268–73. Bibcode:1997PNAS...9412268K. doi:10.1073/pnas.94.23.12268. PMC 24903. PMID 9356438.
^ Finkelstein A, Kostrub CF, Li J, Chavez DP, Wang BQ, Fang SM, Greenblatt J, Burton ZF (1992). "A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II". Nature. 355 (6359): 464–7. Bibcode:1992Natur.355..464F. doi:10.1038/355464a0. PMID 1734284. S2CID 1241044.
^ Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet. 3 (1): 61–4. doi:10.1093/hmg/3.1.61. PMID 8162052.
^ Purrello M, Di Pietro C, Rapisarda A, Mirabile E, Motta S, Sichel G, Grzeschik KH (1995). "Genetic characterization of general transcription factors TFIIF and TFIIB of Homo sapiens sapiens". Cytogenet. Cell Genet. 69 (1–2): 75–80. doi:10.1159/000133942. PMID 7835093.

External links

Transcription+Factor+TFIIF at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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[isbn0-13-144946-X-1] Lewin, Benjamin (2004). Genes VIII. Upper Saddle River, NJ: Pearson Prentice Hall. pp. 636–637. ISBN 0-13-144946-X.

[pmid11092823-2] Lee TI, Young RA (2000). "Transcription of eukaryotic protein-coding genes". Annu. Rev. Genet. 34: 77–137. doi:10.1146/annurev.genet.34.1.77. PMID 11092823.

[3] Kim TK, Lagrange T, Wang YH, Griffith JD, Reinberg D, Ebright RH (1997). "Trajectory of DNA in the RNA polymerase II transcription preinitiation complex". Proc Natl Acad Sci USA. 94 (23): 12268–73. Bibcode:1997PNAS...9412268K. doi:10.1073/pnas.94.23.12268. PMC 24903. PMID 9356438.

[pmid1734284-4] Finkelstein A, Kostrub CF, Li J, Chavez DP, Wang BQ, Fang SM, Greenblatt J, Burton ZF (1992). "A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II". Nature. 355 (6359): 464–7. Bibcode:1992Natur.355..464F. doi:10.1038/355464a0. PMID 1734284. S2CID 1241044.

[pmid8162052-5] Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet. 3 (1): 61–4. doi:10.1093/hmg/3.1.61. PMID 8162052.

[pmid7835093-6] Purrello M, Di Pietro C, Rapisarda A, Mirabile E, Motta S, Sichel G, Grzeschik KH (1995). "Genetic characterization of general transcription factors TFIIF and TFIIB of Homo sapiens sapiens". Cytogenet. Cell Genet. 69 (1–2): 75–80. doi:10.1159/000133942. PMID 7835093.

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[2]

[3]

[4]

[5]

[6]

Transcription factor II F

See also

References

External links