MacLaine or Maclaine (Gaelic: Mac Gill-Eain) is a surname of Scottish origin. It may refer to:
;- Persons
- Angus Gillean Mathew Maclaine, Younger of Lochbuie, Tannist to Lorne, 26th of Lochbuie
- Christopher Maclaine (1923–1975), American poet and filmmaker
- Gillean Maclaine (1921–1970), Scottish chief of Clan Maclaine of Lochbuie
- James MacLaine (1724–1750), Irish highwayman
- Lorne Maclaine (contemporary), Scottish chief of Clan Maclaine of Lochbuie, son of Gillean
- Mark Maclaine (contemporary), English musician
- Sarah Maclaine, Australian jazz singer
- Shirley MacLaine (born 1934), American actress
- Scottish clan
- Fictional persons
- Jake Maclaine, character from the American soap opera The Bold and the Beautiful
- Mark Maclaine (The Bold and the Beautiful), character from the American soap opera The Bold and the Beautiful