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Ergotamine/caffeine, sold under the brand name Cafergot among others, is a fixed-dose combination medication used for the treatment of migraine. It contains ergotamine, as the tartrate, an alpha adrenergic blocking agent; and caffeine, a cranial vasoconstrictor.[3]
| Combination of | |
|---|---|
| Ergotamine | vasoconstrictor, neurotransmitter agonist and antagonist |
| Caffeine | vasoconstrictor, phosphodiesterase inhibitor |
| Clinical data | |
| Trade names | Cafergot, Migergot, others |
| AHFS/Drugs.com | Multum Consumer Information |
| MedlinePlus | a601048 |
| License data | |
| Pregnancy category |
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| Routes of administration | By mouth, rectal |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| KEGG | |
Ergotamine/caffeine is available as a generic medication.
Medical uses
editErgotamine/caffeine is indicated as therapy to abort or prevent vascular headache.[1][2]
Mechanism of action
editErgotamine binds to 5HT 1b/d receptors.[4] This along with binding to other serotonergic and dopaminergic receptors is their presumed mechanism of action in treating migraine.[4][5]
Adverse effects
editBecause the vasoconstrictive effects of ergotamine and caffeine are not selective for the brain, adverse effects due to systemic vasoconstriction can occur. Cold feet or hands, angina pectoris, myocardial infarction,[6] or dizziness are some examples.
It has also been shown to be associated with mitral valve stenosis. [7]
References
edit- ^ a b "Cafergot- ergotamine tartrate and caffeine tablet, film coated". DailyMed. U.S. National Library of Medicine. Archived from the original on 16 January 2014.
- ^ a b "Migergot- ergotamine tartrate and caffeine suppository". DailyMed. 29 November 2022. Retrieved 18 May 2024.
- ^ Diener HC, Jansen JP, Reches A, Pascual J, Pitei D, Steiner TJ (2002). "Efficacy, tolerability and safety of oral eletriptan and ergotamine plus caffeine (Cafergot) in the acute treatment of migraine: a multicentre, randomised, double-blind, placebo-controlled comparison". European Neurology. 47 (2): 99–107. doi:10.1159/000047960. PMID 11844898. S2CID 72629130.
- ^ a b "Acute treatment of migraine in adults". UpToDate. Wolters Kluwer. 15 January 2018. Retrieved 27 March 2018.
- ^ Fanciullacci M, Granchi G, Sicuteri F (November 1976). "Ergotamine and methysergide as serotonin partial agonists in migraine". Headache. 16 (5): 226–231. doi:10.1111/j.1526-4610.1976.hed1605226.x. PMID 977328. S2CID 45861917.
- ^ Olesen J, Goadsby PJ, Ramadan NM, Tfelt-Hansen P, Michael K, Welch A, eds. (2006). The Headaches (3rd ed.). Lippincott Williams and Wilkins. p. 463. ISBN 978-0781754002.
- ^ Austin SM, el-Hayek A, Comianos M, Tamulonis DJ (October 1993). "Mitral valve disease associated with long-term ergotamine use". Southern Medical Journal. 86 (10): 1179–1181. doi:10.1097/00007611-199310000-00024. PMID 8211344.