WDTC1 ("Adipose") is a gene associated with obesity.[1][2][3]
| WD and tetratricopeptide repeats 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | WDTC1 | ||||||
| NCBI gene | 23038 | ||||||
| HGNC | 29175 | ||||||
| RefSeq | NM_015023 | ||||||
| UniProt | Q8N5D0 | ||||||
| Other data | |||||||
| Locus | Chr. 1 p35.3 | ||||||
| |||||||
WDTC1 is a gene that codes for a protein acting as a suppressor in lipid accumulation. WDTC1 protein consists of seven WD40 domains, three transient receptor potential channel protein-protein interaction domains, DDB1 binding elements, and a prenylated C-terminus.[4] Reduced expression or disruption of WDTC1 gene is associated with obesity, increased triglyceride accumulation, and adipogenesis. WDTC1 is a factor in a complex composed of DDB1, CUL4, and ROC1 that restricts transcription in adipogenesis. [5]
Model organisms
editStudies of phenotype of mice showed that having a loss of an allele resulted in obesity and poor metabolic profiles. Transgenic expression of the WDTC1 gene in mice showed the opposite effect with mice having less adipose.[6]
References
edit- ^ Suh JM, Zeve D, McKay R, Seo J, Salo Z, Li R, et al. (September 2007). "Adipose is a conserved dosage-sensitive antiobesity gene". Cell Metabolism. 6 (3): 195–207. doi:10.1016/j.cmet.2007.08.001. PMC 2587167. PMID 17767906.
- ^ "ScienceDaily: 'Skinny Gene' Exists". Retrieved 2007-09-05.
- ^ Lai CQ, Parnell LD, Arnett DK, García-Bailo B, Tsai MY, Kabagambe EK, et al. (March 2009). "WDTC1, the ortholog of Drosophila adipose gene, associates with human obesity, modulated by MUFA intake". Obesity. 17 (3): 593–600. doi:10.1038/oby.2008.561. PMC 2874970. PMID 19238144.
- ^ Ducos E, Vergès V, Dugé de Bernonville T, Blanc N, Giglioli-Guivarc'h N, Dutilleul C (September 2017). "Remarkable Evolutionary Conservation of Antiobesity ADIPOSE/WDTC1 Homologs in Animals and Plants". Genetics. 207 (1): 153–162. doi:10.1534/genetics.116.198382. PMC 5586369. PMID 28663238.
- ^ Groh BS, Yan F, Smith MD, Yu Y, Chen X, Xiong Y (May 2016). "The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase". EMBO Reports. 17 (5): 638–47. doi:10.15252/embr.201540500. PMC 5341520. PMID 27113764.
- ^ Groh BS, Yan F, Smith MD, Yu Y, Chen X, Xiong Y (May 2016). "The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase". EMBO Reports. 17 (5): 638–47. doi:10.15252/embr.201540500. PMC 5341520. PMID 27113764.