The Great Lakes region of South Dakota is in the central part of the state in the United States of America. It follows the course of the Missouri River from North Dakota South to Nebraska.

Map of Great Lakes (South Dakota)

• 44.368361-100.3511391 Pierre — in the capital of the state, on the Missouri river, you can visit the state Capitol building and several museums, or go fishing at the Oahe Dam lake
• 43.805556-99.3283332 Chamberlain — along the east bank of the Missouri River
• 43.804167-99.3802783 Oacoma
• 45.505556-100.0313894 Selby
• 43.373889-99.8577785 Winner

• 44.382778-100.2861111 Pierre Regional Airport (PIR ^IATA). (updated Mar 2024)

• 43.8253-99.324781 Atka Lakota Museum and Cultural Center, 1301 N Main St, Chamberlain, ☏ +1 605 234-3452, toll-free: +1-800-798-3452. May-Oct: M-Sa 8AM-6PM, Su 9AM-5PM; Nov-Apr: M-Sa 8AM-5PM. Free. 
• 43.79664-99.341612 South Dakota Hall of Fame, 1480 S Main St, Chamberlain (I-90 Exit 263), ☏ +1 605 234-4216, toll-free: +1-800-697-3130. Memorial Day-Labor Day: M-F 8AM-6PM, Sa-Su 9AM-5PM; Labor Day-Memorial Day: M-F 9AM-5PM. The official hall of fame of South Dakota. Free. 
• 45.4489-100.0382833 Bangor Monument, Selby (5 mi (8.0 km) south of town on US Hwy 83). Roadside marker located at spot of the vanished town of Bangor. 

• 43.81091-99.333311 Best Western Lee's Motor Inn, 220 W King Ave, Chamberlain, ☏ +1 605 734-5575, toll-free: +1-800-780-7234, fax: +1 605 234-6555. Check-in: 2PM, check-out: 11AM. 
• 43.80295-99.390622 Econo Lodge, 400 East SD Highway 16, Oacoma, ☏ +1 605 734-4100. It has a pool and hot tub. 
• 43.3773-99.842443 Super 8, 902 East Highway 44 (Winner), ☏ +1 605-646-0368. Check-in: 3PM, check-out: 11AM. 
• 43.37591-99.84534 Knights Inn, 845 SD-44 (Winner).