PDCD2

PDCD2
Identifiers
Aliases	PDCD2, RP8, ZMYND7, programmed cell death 2
External IDs	OMIM: 600866; MGI: 104643; HomoloGene: 1951; GeneCards: PDCD2; OMA:PDCD2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	170,584,692 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	15,747,563 bp
RNA expression pattern
	Top expressed in
	gonad; ; body of pancreas; ; rectum; ; granulocyte; ; Achilles tendon; ; body of stomach; ; monocyte; ; right coronary artery; ; ganglionic eminence; ; islet of Langerhans;
	Top expressed in
	tail of embryo; ; fossa; ; primitive streak; ; epiblast; ; facial motor nucleus; ; genital tubercle; ; condyle; ; medial ganglionic eminence; ; embryo; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	enzyme binding; DNA binding; protein binding; metal ion binding;
Cellular component	cytoplasm; extracellular exosome; nucleus;
Biological process	positive regulation of apoptotic process; positive regulation of hematopoietic stem cell proliferation; regulation of hematopoietic progenitor cell differentiation; activation of cysteine-type endopeptidase activity involved in apoptotic process; programmed cell death; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	5134
	18567
	ENSG00000071994
	ENSMUSG00000014771
	Q16342
	P46718
NM_001199461; NM_001199462; NM_001199463; NM_001199464; NM_002598;
	NM_144781; NM_001363655
	NM_008799
NP_001186390; NP_001186391; NP_001186392; NP_001186393; NP_002589;
	NP_659005; NP_001350584
	NP_032825
	Wikidata
View/Edit Human	View/Edit Mouse

Programmed cell death protein 2 is a protein that in humans is encoded by the PDCD2 gene.^[5]^[6]

Function

This gene encodes a nuclear protein expressed in a variety of tissues. The rat homolog, Rp8, is transiently expressed in immature thymocytes and is thought to be involved in programmed cell death. Expression of the human gene has been shown to be repressed by BCL6, a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on PDCD2. This gene is closely linked on chromosome 6 to the gene for TBP, the TATA binding protein. Six transcripts encoding different proteins have been identified.^[6]

Interactions

PDCD2 has been shown to interact with Host cell factor C1^[7] and Parkin (ligase).^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000071994 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000014771 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kawakami T, Furukawa Y, Sudo K, Saito H, Takami S, Takahashi E, Nakamura Y (Aug 1995). "Isolation and mapping of a human gene (PDCD2) that is highly homologous to Rp8, a rat gene associated with programmed cell death". Cytogenetics and Cell Genetics. 71 (1): 41–3. doi:10.1159/000134058. PMID 7606924.
^ ^a ^b "Entrez Gene: PDCD2 programmed cell death 2".
^ Scarr RB, Sharp PA (Aug 2002). "PDCD2 is a negative regulator of HCF-1 (C1)". Oncogene. 21 (34): 5245–54. doi:10.1038/sj.onc.1205647. PMID 12149646.
^ Fukae J, Sato S, Shiba K, Sato K, Mori H, Sharp PA, Mizuno Y, Hattori N (Feb 2009). "Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease". FEBS Letters. 583 (3): 521–5. doi:10.1016/j.febslet.2008.12.055. hdl:1721.1/96274. PMID 19146857. S2CID 7121769.

Baron BW, Anastasi J, Thirman MJ, Furukawa Y, Fears S, Kim DC, Simone F, Birkenbach M, Montag A, Sadhu A, Zeleznik-Le N, McKeithan TW (Mar 2002). "The human programmed cell death-2 (PDCD2) gene is a target of BCL6 repression: implications for a role of BCL6 in the down-regulation of apoptosis". Proceedings of the National Academy of Sciences of the United States of America. 99 (5): 2860–5. Bibcode:2002PNAS...99.2860B. doi:10.1073/pnas.042702599. PMC 122438. PMID 11854457.
Scarr RB, Sharp PA (Aug 2002). "PDCD2 is a negative regulator of HCF-1 (C1)". Oncogene. 21 (34): 5245–54. doi:10.1038/sj.onc.1205647. PMID 12149646.
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Chen Q, Qian K, Yan C (Dec 2005). "Cloning of cDNAs with PDCD2(C) domain and their expressions during apoptosis of HEK293T cells". Molecular and Cellular Biochemistry. 280 (1–2): 185–91. doi:10.1007/s11010-005-8910-z. PMID 16311922. S2CID 6208880.
Baron BW, Zeleznik-Le N, Baron MJ, Theisler C, Huo D, Krasowski MD, Thirman MJ, Baron RM, Baron JM (May 2007). "Repression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomas". Proceedings of the National Academy of Sciences of the United States of America. 104 (18): 7449–54. Bibcode:2007PNAS..104.7449B. doi:10.1073/pnas.0701770104. PMC 1863460. PMID 17468402.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000071994 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000014771 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7606924-5] Kawakami T, Furukawa Y, Sudo K, Saito H, Takami S, Takahashi E, Nakamura Y (Aug 1995). "Isolation and mapping of a human gene (PDCD2) that is highly homologous to Rp8, a rat gene associated with programmed cell death". Cytogenetics and Cell Genetics. 71 (1): 41–3. doi:10.1159/000134058. PMID 7606924.

[entrez-6] "Entrez Gene: PDCD2 programmed cell death 2".

[pmid12149646-7] Scarr RB, Sharp PA (Aug 2002). "PDCD2 is a negative regulator of HCF-1 (C1)". Oncogene. 21 (34): 5245–54. doi:10.1038/sj.onc.1205647. PMID 12149646.

[pmid19146857-8] Fukae J, Sato S, Shiba K, Sato K, Mori H, Sharp PA, Mizuno Y, Hattori N (Feb 2009). "Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease". FEBS Letters. 583 (3): 521–5. doi:10.1016/j.febslet.2008.12.055. hdl:1721.1/96274. PMID 19146857. S2CID 7121769.

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Function

Interactions

References

Further reading