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DEFB106A

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DEFB106A
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesDEFB106A, BD-6, DEFB-6, DEFB106, defensin beta 106A
External IDsHomoloGene: 134659; GeneCards: DEFB106A; OMA:DEFB106A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_152251

n/a

RefSeq (protein)

NP_689464

n/a

Location (UCSC)Chr 8: 7.83 – 7.83 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Beta-defensin 106 is a protein that in humans is encoded by the DEFB106A gene.[3][4]

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 106, DEFB106A and DEFB106B, in head-to-head orientation. This gene, DEFB106A, represents the more centromeric copy.[4]

Function

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The purified DEFB106 showed antimicrobial activity against Escherichia coli, Candida albicans and Staphylococcus aureus.[5]

References

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  1. ^ a b c ENSG00000285617 GRCh38: Ensembl release 89: ENSG00000186579, ENSG00000285617Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A. 99 (4): 2129–33. Bibcode:2002PNAS...99.2129S. doi:10.1073/pnas.042692699. PMC 122330. PMID 11854508.
  4. ^ a b "Entrez Gene: DEFB106A defensin, beta 106A".
  5. ^ Xin A (Jan 2014). "Soluble fusion expression, characterization and localization of human β-defensin 6..." Mol Med Rep. 9 (1): 149–55. doi:10.3892/mmr.2013.1768. PMID 24189797.

Further reading

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