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Bcl-2-like protein 1

From Wikipedia, the free encyclopedia
(Redirected from BCL2-like 1 (gene))
BCL2L1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBCL2L1, Bcl2l1, Bcl(X)L, Bcl-XL, Bcl2l, BclX, bcl-x, bcl2-L-1, BCL-XL/S, BCLXL, BCLXS, PPP1R52, bcl-xS, BCL2L, BCLX, Bcl-X, bcl-xL, BCL2 like 1
External IDsOMIM: 600039; MGI: 88139; HomoloGene: 7639; GeneCards: BCL2L1; OMA:BCL2L1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

598

12048

Ensembl

ENSG00000171552

ENSMUSG00000007659

UniProt

Q07817
Q5TE64

Q64373

RefSeq (mRNA)

NM_001289716
NM_001289717
NM_001289739
NM_009743
NM_001355053

RefSeq (protein)

NP_001276645
NP_001276646
NP_001276668
NP_033873
NP_001341982

Location (UCSC)Chr 20: 31.66 – 31.72 MbChr 2: 152.62 – 152.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Bcl-2-like protein 1 is a protein encoded in humans by the BCL2L1 gene. Through alternative splicing, the gene encodes both of the human proteins Bcl-xL and Bcl-xS.[5]

Function

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The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (voltage-dependent anion channels (VDACs) opening. VDACs regulate mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform (Bcl-xL) acts as an apoptotic inhibitor and the shorter form (Bcl-xS) acts as an apoptotic activator.[5][6]

Interactions

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BCL2-like 1 (gene) has been shown to interact with:

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171552 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000007659 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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  6. ^ "Entrez Gene: BCL2L1 BCL2-like 1".
  7. ^ Hu Y, Benedict MA, Wu D, Inohara N, Núñez G (Apr 1998). "Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation". Proceedings of the National Academy of Sciences of the United States of America. 95 (8): 4386–91. Bibcode:1998PNAS...95.4386H. doi:10.1073/pnas.95.8.4386. PMC 22498. PMID 9539746.
  8. ^ Pan G, O'Rourke K, Dixit VM (Mar 1998). "Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex". The Journal of Biological Chemistry. 273 (10): 5841–5. doi:10.1074/jbc.273.10.5841. PMID 9488720.
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Further reading

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