PRUNE2

PRUNE2
Identifiers
Aliases	PRUNE2, A214N16.3, BMCC1, BNIPXL, C9orf65, KIAA0367, bA214N16.3, prune homolog 2 (Drosophila), prune homolog 2, prune homolog 2 with BCH domain
External IDs	OMIM: 610691; MGI: 1925004; HomoloGene: 18939; GeneCards: PRUNE2; OMA:PRUNE2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	76,906,114 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	17,201,296 bp
RNA expression pattern
	Top expressed in
	spinal ganglia; ; decidua; ; gastric mucosa; ; Descending thoracic aorta; ; endothelial cell; ; cerebellar vermis; ; popliteal artery; ; tibial arteries; ; ascending aorta; ; corpus callosum;
	Top expressed in
	facial motor nucleus; ; cerebellar cortex; ; lobe of cerebellum; ; medial dorsal nucleus; ; spinal ganglia; ; cerebellar vermis; ; lumbar spinal ganglion; ; trigeminal ganglion; ; lateral geniculate nucleus; ; medial geniculate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	pyrophosphatase activity; metal ion binding; exopolyphosphatase activity;
Cellular component	cytoplasm;
Biological process	apoptotic process; polyphosphate catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	158471
	353211
	ENSG00000106772
	ENSMUSG00000039126
	Q8WUY3
	Q52KR3
NM_001308047; NM_001308048; NM_001308049; NM_001308050; NM_001308051;
	NM_015225; NM_138818; NM_001330680
	NM_181348
NP_001294976; NP_001294977; NP_001294978; NP_001294979; NP_001294980;
	NP_001317609; NP_056040; NP_001294976.1; NP_001294977.1
	NP_851993
	Wikidata
View/Edit Human	View/Edit Mouse

Protein prune homolog 2 is a protein that in humans is encoded by the PRUNE2 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106772 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039126 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Machida T, Fujita T, Ooo ML, Ohira M, Isogai E, Mihara M, Hirato J, Tomotsune D, Hirata T, Fujimori M, Adachi W, Nakagawara A (Mar 2006). "Increased expression of proapoptotic BMCC1, a novel gene with the BNIP2 and Cdc42GAP homology (BCH) domain, is associated with favorable prognosis in human neuroblastomas". Oncogene. 25 (13): 1931–42. doi:10.1038/sj.onc.1209225. PMID 16288218. S2CID 19976655.
^ "Entrez Gene: PRUNE2 prune homolog 2 (Drosophila)".

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID 11181995.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Price ND, Trent J, El-Naggar AK, et al. (2007). "Highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas". Proc. Natl. Acad. Sci. U.S.A. 104 (9): 3414–9. Bibcode:2007PNAS..104.3414P. doi:10.1073/pnas.0611373104. PMC 1805517. PMID 17360660.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106772 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039126 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16288218-5] Machida T, Fujita T, Ooo ML, Ohira M, Isogai E, Mihara M, Hirato J, Tomotsune D, Hirata T, Fujimori M, Adachi W, Nakagawara A (Mar 2006). "Increased expression of proapoptotic BMCC1, a novel gene with the BNIP2 and Cdc42GAP homology (BCH) domain, is associated with favorable prognosis in human neuroblastomas". Oncogene. 25 (13): 1931–42. doi:10.1038/sj.onc.1209225. PMID 16288218. S2CID 19976655.

[entrez-6] "Entrez Gene: PRUNE2 prune homolog 2 (Drosophila)".

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References

Further reading