HTR3B

HTR3B
Identifiers
Aliases	HTR3B, 5-HT3B, 5-hydroxytryptamine receptor 3B
External IDs	OMIM: 604654; MGI: 1861899; HomoloGene: 38131; GeneCards: HTR3B; OMA:HTR3B - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	113,949,079 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	48,876,290 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; right frontal lobe; ; Brodmann area 9; ; anterior cingulate cortex; ; primary visual cortex; ; superior frontal gyrus; ; gonad; ; kidney; ; human kidney; ; amygdala;
	Top expressed in
	lumbar spinal ganglion; ; female external genitalia; ; urethra; ; autonomic nervous system; ; sympathetic ganglion; ; cervical ganglion; ; glossopharyngeal ganglion; ; stellate ganglion; ; embryo; ; tunica adventitia of aorta;
	More reference expression data
	n/a
Gene ontology
Molecular function	extracellular ligand-gated ion channel activity; ligand-gated ion channel activity; serotonin-gated cation-selective channel activity; ion channel activity; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; membrane; cell surface; plasma membrane; postsynaptic membrane; integral component of plasma membrane; serotonin-activated cation-selective channel complex; neuron projection; synapse;
Biological process	ion transport; signal transduction; ion transmembrane transport; serotonin receptor signaling pathway; chemical synaptic transmission; regulation of membrane potential; nervous system process;
	Sources:Amigo / QuickGO
Orthologs
	9177
	57014
	ENSG00000149305
	ENSMUSG00000008590
	O95264
	Q9JHJ5
	NM_006028; NM_001363563
	NM_020274
	NP_006019; NP_001350492
	NP_064670
	Wikidata
View/Edit Human	View/Edit Mouse

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5-hydroxytryptamine (serotonin) receptor 3B, also known as HTR3B, is a human gene. The protein encoded by this gene is a subunit of the 5-HT3 receptor.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000149305 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000008590 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Davies PA, Pistis M, Hanna MC, Peters JA, Lambert JJ, Hales TG, Kirkness EF (January 1999). "The 5-HT3B subunit is a major determinant of serotonin-receptor function". Nature. 397 (6717): 359–363. Bibcode:1999Natur.397..359D. doi:10.1038/16941. PMID 9950429. S2CID 4401851.
^ Dubin AE, Huvar R, D'Andrea MR, Pyati J, Zhu JY, Joy KC, Wilson SJ, Galindo JE, Glass CA, Luo L, Jackson MR, Lovenberg TW, Erlander MG (October 1999). "The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit". J. Biol. Chem. 274 (43): 30799–30810. doi:10.1074/jbc.274.43.30799. PMID 10521471.

Need AC, Keefe RS, Ge D, et al. (2009). "Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis". Eur. J. Hum. Genet. 17 (7): 946–957. doi:10.1038/ejhg.2008.264. PMC 2986499. PMID 19156168.
Meineke C, Tzvetkov MV, Bokelmann K, et al. (2008). "Functional characterization of a -100_-102delAAG deletion-insertion polymorphism in the promoter region of the HTR3B gene". Pharmacogenet. Genomics. 18 (3): 219–230. doi:10.1097/FPC.0b013e3282f51092. PMID 18300944. S2CID 44722598.
Levran O, Londono D, O'Hara K, et al. (2008). "Genetic susceptibility to heroin addiction; a candidate-gene association study". Genes, Brain and Behavior. 7 (7): 720–729. doi:10.1111/j.1601-183X.2008.00410.x. PMC 2885890. PMID 18518925.
Kato M, Fukuda T, Wakeno M, et al. (2006). "Effects of the serotonin type 2A, 3A and 3B receptor and the serotonin transporter genes on paroxetine and fluvoxamine efficacy and adverse drug reactions in depressed Japanese patients". Neuropsychobiology. 53 (4): 186–195. doi:10.1159/000094727. PMID 16874005. S2CID 25730662.
Hu XQ, Peoples RW (2008). "The 5-HT3B subunit confers spontaneous channel opening and altered ligand properties of the 5-HT3 receptor". J. Biol. Chem. 283 (11): 6826–6831. doi:10.1074/jbc.M707571200. PMID 18187416.
Krzywkowski K, Davies PA, Feinberg-Zadek PL, et al. (2008). "High-frequency HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor". Proc. Natl. Acad. Sci. U.S.A. 105 (2): 722–727. Bibcode:2008PNAS..105..722K. doi:10.1073/pnas.0708454105. PMC 2206603. PMID 18184810.
Ji X, Takahashi N, Branko A, et al. (2008). "An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population". Nagoya Journal of Medical Science. 70 (1–2): 11–17. PMID 18807291.
Kato M, Serretti A (2008). "Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder". Mol. Psychiatry. 15 (5): 473–500. doi:10.1038/mp.2008.116. PMID 18982004.
Walstab J, Hammer C, Bönisch H, et al. (2008). "Naturally occurring variants in the HTR3B gene significantly alter properties of human heteromeric 5-hydroxytryptamine-3A/B receptors". Pharmacogenet. Genomics. 18 (9): 793–802. doi:10.1097/FPC.0b013e3283050117. PMID 18698232. S2CID 61196.
Yosifova A, Mushiroda T, Stoianov D, et al. (2009). "Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population". Journal of Affective Disorders. 117 (1–2): 87–97. doi:10.1016/j.jad.2008.12.021. PMID 19328558.
Tzvetkov MV, Meineke C, Oetjen E, et al. (2007). "Tissue-specific alternative promoters of the serotonin receptor gene HTR3B in human brain and intestine". Gene. 386 (1–2): 52–62. doi:10.1016/j.gene.2006.08.002. PMID 17010535.
Oades RD, Lasky-Su J, Christiansen H, et al. (2008). "The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis". Behavioral and Brain Functions. 4: 48. doi:10.1186/1744-9081-4-48. PMC 2577091. PMID 18937842.
Fasching PA, Kollmannsberger B, Strissel PL, et al. (2008). "Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy". J. Cancer Res. Clin. Oncol. 134 (10): 1079–1086. doi:10.1007/s00432-008-0387-1. PMID 18389280. S2CID 7504731.
Tanaka M, Kobayashi D, Murakami Y, et al. (2008). "Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea". Int. J. Neuropsychopharmacol. 11 (2): 261–267. doi:10.1017/S1461145707007985. PMID 17697394.
Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–816. doi:10.1002/ajmg.b.30902. PMID 19086053. S2CID 44524739.
Krzywkowski K, Davies PA, Irving AJ, et al. (2008). "Characterization of the effects of four HTR3B polymorphisms on human 5-HT3AB receptor expression and signalling". Pharmacogenet. Genomics. 18 (12): 1027–1040. doi:10.1097/FPC.0b013e328310f950. PMID 19008750. S2CID 6026971.
Smith AK, Dimulescu I, Falkenberg VR, et al. (2008). "Genetic evaluation of the serotonergic system in chronic fatigue syndrome". Psychoneuroendocrinology. 33 (2): 188–197. doi:10.1016/j.psyneuen.2007.11.001. PMID 18079067. S2CID 34029937.
de Krom M, Staal WG, Ophoff RA, et al. (2009). "A common variant in DRD3 receptor is associated with autism spectrum disorder". Biol. Psychiatry. 65 (7): 625–630. doi:10.1016/j.biopsych.2008.09.035. PMID 19058789. S2CID 11545813.
Ducci F, Enoch MA, Yuan Q, et al. (2009). "HTR3B is associated with alcoholism with antisocial behavior and alpha EEG power—an intermediate phenotype for alcoholism and co-morbid behaviors". Alcohol. 43 (1): 73–84. doi:10.1016/j.alcohol.2008.09.005. PMC 2754808. PMID 19185213.

External links

HTR3B+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000149305 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000008590 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9950429-5] Davies PA, Pistis M, Hanna MC, Peters JA, Lambert JJ, Hales TG, Kirkness EF (January 1999). "The 5-HT3B subunit is a major determinant of serotonin-receptor function". Nature. 397 (6717): 359–363. Bibcode:1999Natur.397..359D. doi:10.1038/16941. PMID 9950429. S2CID 4401851.

[pmid10521471-6] Dubin AE, Huvar R, D'Andrea MR, Pyati J, Zhu JY, Joy KC, Wilson SJ, Galindo JE, Glass CA, Luo L, Jackson MR, Lovenberg TW, Erlander MG (October 1999). "The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit". J. Biol. Chem. 274 (43): 30799–30810. doi:10.1074/jbc.274.43.30799. PMID 10521471.

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References

Further reading

External links