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CNKSR3

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CNKSR3

Identifiers

CNKSR3, MAGI1, CNKSR family member 3, CNK3, CNK3/IPCEF1

External IDs

OMIM: 617476; MGI: 2674130; HomoloGene: 18192; GeneCards: CNKSR3; OMA:CNKSR3 - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6q25.2	Start	154,387,504 bp^[1]
Band	6q25.2	End	154,510,659 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10\|10 A1	Start	7,069,063 bp^[2]
Band	10\|10 A1	End	7,162,237 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

retinal pigment epithelium

mucosa of ileum

cartilage tissue

palpebral conjunctiva

amniotic fluid

vena cava

tibia

oral cavity

ventricular zone

parotid gland

Top expressed in

renal corpuscle

ciliary body

conjunctival fornix

lobe of cerebellum

endothelial cell of lymphatic vessel

cerebellar vermis

otolith organ

utricle

cornea

iris

More reference expression data

n/a

Gene ontology
Molecular function	protein binding
Cellular component	cytoplasm membrane plasma membrane apical plasma membrane
Biological process	regulation of signal transduction positive regulation of sodium ion transport negative regulation of peptidyl-serine phosphorylation negative regulation of ERK1 and ERK2 cascade positive regulation of sodium ion transmembrane transporter activity
Sources:Amigo / QuickGO

Species

Human

Mouse


154043


215748


ENSG00000153721


ENSMUSG00000015202


Q6P9H4


Q8BMA3

RefSeq (mRNA)


NM_173515


NM_172546

RefSeq (protein)


NP_775786 NP_001355045 NP_001355046 NP_001355047 NP_001355048


NP_766134

Location (UCSC)

Chr 6: 154.39 – 154.51 Mb

Chr 10: 7.07 – 7.16 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

CNKSR family member 3 is a protein that in humans is encoded by the CNKSR3 gene. ^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000153721 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015202 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CNKSR family member 3". Retrieved 2018-08-31.

Further reading

Ziera T, Irlbacher H, Fromm A, Latouche C, Krug SM, Fromm M, Jaisser F, Borden SA (November 2009). "Cnksr3 is a direct mineralocorticoid receptor target gene and plays a key role in the regulation of the epithelial sodium channel". FASEB J. 23 (11): 3936–46. doi:10.1096/fj.09-134759. PMID 19567370. S2CID 7476404.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Attar MA, Salem JC, Pursel HS, Santy LC (February 2012). "CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration". Exp. Cell Res. 318 (3): 228–37. doi:10.1016/j.yexcr.2011.10.018. PMID 22085542.
Shin S, Park JS, Kim YJ, Oh T, An S, Park CS (May 2012). "Differential gene expression profile in PBMCs from subjects with AERD and ATA: a gene marker for AERD". Mol. Genet. Genomics. 287 (5): 361–71. doi:10.1007/s00438-012-0685-9. PMID 22457146. S2CID 14306121.
Soundararajan R, Ziera T, Koo E, Ling K, Wang J, Borden SA, Pearce D (September 2012). "Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex". J. Biol. Chem. 287 (39): 33014–25. doi:10.1074/jbc.M112.389148. PMC 3463358. PMID 22851176.
Lake SL, Damato BE, Kalirai H, Dodson AR, Taktak AF, Lloyd BH, Coupland SE (March 2013). "Single nucleotide polymorphism array analysis of uveal melanomas reveals that amplification of CNKSR3 is correlated with improved patient survival". Am. J. Pathol. 182 (3): 678–87. doi:10.1016/j.ajpath.2012.11.036. PMID 23357503.

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