1,634 results found
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Aggregating in vitro-grown adipocytes to produce macroscale cell-cultured fat tissue with tunable lipid compositions for food applications

    John Se Kit Yuen Jr, Michael K Saad ... David L Kaplan
    A simple way to create larger volumes of fat tissue for food purposes may be to grow individual fat cells and mechanically combine them together (rather than directly growing the full tissue).
    1. Cell Biology

    Endothelial-specific FoxO1 depletion prevents obesity-related disorders by increasing vascular metabolism and growth

    Martina Rudnicki, Ghoncheh Abdifarkosh ... Tara L Haas
    Stimulation of endothelial glucose metabolism and vascular growth by genetic depletion of endothelial Foxo1 improves the whole-body response to a high-fat diet, by preserving adipose tissue functions and glucose homeostasis.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Enhanced C/EBPβ function promotes hyperplastic versus hypertrophic fat tissue growth and prevents steatosis in response to high-fat diet feeding

    Christine Müller, Laura M Zidek ... Cornelis F Calkhoven
    Gene regulation by C/EBPβ determines how surplus of dietary fat is stored, which has consequences for metabolic health.
    1. Cell Biology
    2. Developmental Biology

    The Drosophila F-box protein Fbxl7 binds to the protocadherin Fat and regulates Dachs localization and Hippo signaling

    Justin A Bosch, Taryn M Sumabat ... Iswar K Hariharan
    The F-box protein Fbxl7 is a direct effector of the protocadherin Fat and functions in downstream pathways that regulate tissue shape and size.
    1. Medicine

    Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesity

    Chandramohan Chitraju, Alexander W Fischer ... Robert V Farese Jr
    Inhibiting triglyceride storage in adipose tissue prevents obesity and improves metabolic health.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Comparative multi-tissue profiling reveals extensive tissue-specificity in transcriptome reprogramming during thermal adaptation

    Noushin Hadadi, Martina Spiljar ... Mirko Trajkovski
    Integrative analysis of multi-tissue transcriptomics data of mice subjected to cold, mild warm or room temperature places the thermal adaptation of individual tissues in a whole-organism perspective.
    1. Cell Biology
    2. Developmental Biology

    Coordination of planar cell polarity pathways through Spiny-legs

    Abhijit A Ambegaonkar, Kenneth D Irvine
    A direct connection between distinct planar cell polarity systems orients cells, answering long-standing questions regarding the relationship between systems and the orientation of cell polarity.
    1. Developmental Biology

    Targeting senescent cells enhances adipogenesis and metabolic function in old age

    Ming Xu, Allyson K Palmer ... James L Kirkland
    Senescent cells contribute to age-related fat dysfunction and can directly impair healthy fat progenitor function, in part, via the secretion of activin A.
    1. Developmental Biology

    TAF7L modulates brown adipose tissue formation

    Haiying Zhou, Bo Wan ... Robert Tjian
    TAF7L acts as a molecular switch that regulates the development of mesenchymal stem cells.
    1. Genetics and Genomics
    2. Neuroscience

    Neuropeptide ACP facilitates lipid oxidation and utilization during long-term flight in locusts

    Li Hou, Siyuan Guo ... Xianhui Wang
    CRISPR/Cas 9 technology and multiple-omics study reveal an essential regulatory role of neuropeptide ACP in lipid utilization related to prolonged flight of locusts.

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