PGR

PGR
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4OAR, 1A28, 1E3K, 1SQN, 1SR7, 1ZUC, 2C7A, 2OVH, 2OVM, 2W8Y, 3D90, 3G8O, 3HQ5, 3KBA, 3ZR7, 3ZRA, 3ZRB, 4A2J, 4APU, 5CC0
Dynodwyr
Cyfenwau	PGR, NR3C3, PR, progesterone receptor
Dynodwyr allanol	OMIM: 607311 HomoloGene: 713 GeneCards: PGR
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • sequence-specific DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • ATPase binding; • zinc ion binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • metal ion binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • steroid hormone receptor activity; • steroid binding; • GO:0001948, GO:0016582 protein binding; • enzyme binding; • signaling receptor binding; • lipid binding; • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity; • identical protein binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cydrannau o'r gell	• cytoplasm; • bilen; • nucleoplasm; • mitochondrial outer membrane; • mitocondria; • cnewyllyn cell; • cytosol;
Prosesau biolegol	• GO:0009373 regulation of transcription, DNA-templated; • cell-cell signaling; • negative regulation of gene expression; • transcription, DNA-templated; • transcription initiation from RNA polymerase II promoter; • GO:0072468 signal transduction; • steroid hormone mediated signaling pathway; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • ovulation from ovarian follicle; • epithelial cell maturation; • mammary gland development; • paracrine signaling; • lung alveolus development; • regulation of epithelial cell proliferation; • progesterone receptor signaling pathway; • tertiary branching involved in mammary gland duct morphogenesis;
	Sources:Amigo / QuickGO
Orthologau
	5241
	n/a
	ENSG00000082175
	n/a
	P06401
	n/a
	NM_000926; NM_001202474; NM_001271161; NM_001271162
	n/a
	NP_000917; NP_001189403; NP_001258090; NP_001258091
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PGR yw PGR a elwir hefyd yn Progesterone receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q22.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PGR.

PR
NR3C3

Llyfryddiaeth

"No association between the progesterone receptor gene polymorphism (+331G/a) and the risk of breast cancer: an updated meta-analysis. ". BMC Med Genet. 2017. PMID 29084518.
"Progesterone Receptor Isoform Ratio: A Breast Cancer Prognostic and Predictive Factor for Antiprogestin Responsiveness. ". J Natl Cancer Inst. 2017. PMID 28376177.
"Selection of Progesterone Derivatives Specific to Membrane Progesterone Receptors. ". Biochemistry (Mosc). 2017. PMID 28320297.
"Inflammatory Stimuli Increase Progesterone Receptor-A Stability and Transrepressive Activity in Myometrial Cells. ". Endocrinology. 2017. PMID 27886516.
"Human Parturition Involves Phosphorylation of Progesterone Receptor-A at Serine-345 in Myometrial Cells.". Endocrinology. 2016. PMID 27653036.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] PGR - Cronfa NCBI

[1]

[2]