NFASC

NFASC
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3P3Y, 3P40
Dynodwyr
Cyfenwau	NFASC, NF, NRCAML, neurofascin, NEDCPMD
Dynodwyr allanol	OMIM: 609145 HomoloGene: 24945 GeneCards: NFASC
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein domain specific binding • GO:0001948, GO:0016582 protein binding • protein binding involved in heterotypic cell-cell adhesion Cydrannau o'r gell • integral component of membrane • bilen • focal adhesion • myelin sheath • Cellbilen • Schwann cell microvillus • intracellular anatomical structure • axon • paranodal junction • axon initial segment • paranode region of axon • extracellular exosome • node of Ranvier • ficolin-1-rich granule membrane • dendrite • integral component of plasma membrane Prosesau biolegol • clustering of voltage-gated sodium channels • peripheral nervous system development • transmission of nerve impulse • heterotypic cell-cell adhesion • synapse organization • protein localization to paranode region of axon • cell adhesion • paranodal junction assembly • myelination • protein localization to juxtaparanode region of axon • axon guidance • neutrophil degranulation • protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	23114	n/a
Ensembl	ENSG00000163531	n/a
UniProt	O94856	n/a
RefSeq (mRNA)	NM_001005387 NM_001005388 NM_001005389 NM_001160331 NM_001160332 NM_001160333 NM_015090 NM_001365986 NM_001378330 NM_001378331 NM_001378329	n/a
RefSeq (protein)	NP_001005388 NP_001005389 NP_001153803 NP_001153804 NP_001153805 NP_055905 NP_001352915 NP_001365259 NP_001365260 NP_001365258	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NFASC yw NFASC a elwir hefyd yn Neurofascin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q32.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NFASC.

• NF
• NRCAML

• "[Neurofascin: a novel target for combined central and peripheral demyelination]. ". Rinsho Shinkeigaku. 2014. PMID 25672685.
• "Neurofascin IgG4 antibodies in CIDP associate with disabling tremor and poor response to IVIg. ". Neurology. 2014. PMID 24523485.
• "Autoantibodies to nodal isoforms of neurofascin in chronic inflammatory demyelinating polyneuropathy. ". Brain. 2017. PMID 28575198.
• "Copy number variation, increased gene expression, and molecular mechanisms of neurofascin in lung cancer. ". Mol Carcinog. 2017. PMID 28418179.
• "Neurofascin-155 IgG4 in chronic inflammatory demyelinating polyneuropathy.". Neurology. 2016. PMID 26843559.